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Article

Analysis of recurrence and survival rates in grade 3 endometrioid endometrial carcinoma

  • Authors:
    • Jieyu Wang
    • Nan Jia
    • Qing Li
    • Chao Wang
    • Xiang Tao
    • Keqin Hua
    • Weiwei Feng
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, P.R. China, Department of Pathology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, P.R. China
  • Pages: 2860-2867
    |
    Published online on: July 28, 2016
       https://doi.org/10.3892/ol.2016.4918
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Abstract

The aim of the present study was to determine risk factors associated with recurrence and survival in patients with grade 3 endometrioid endometrial carcinoma (G3EEC). A retrospective analysis of 117 patients with G3EEC, who were admitted to the Obstetrics and Gynecology Hospital of Fudan University between January 2000 and December 2011, was performed. The χ2 test or Fisher's exact test were used for the comparison of categorical variables. Kaplan‑Meier method was used for estimating recurrence‑free survival (RFS), disease‑specific survival (DSS) and overall survival (OS) rates. Univariate and multivariate Cox proportional hazards model were used to assess the prognostic significance of various patient characteristics. In 117 patients, 16 patients (13.7%) had tumor recurrence, of which 6 (37.5%) developed local‑regional recurrence and 10 (62.5%) developed distant recurrence. Out of the 16 patients with tumor recurrence, 14 (87.5%) had a recurrence within 3 years of surgery. Statistically significant characteristics affecting RFS, DSS and OS rates were outer half myometrial invasion (MI ≥50%), advanced International Federation of Gynecology and Obstetrics stage, positive lymph node metastasis (PLNM), lymph vascular space invasion, adnexal involvement and characterization as a high‑risk group, according to the Gynecologic Oncology Group 99 stratification algorithm. RFS was associated with the depth of cervical mucosa (stromal) involvement. Furthermore, in the multivariate Cox proportional hazards model, significant independent adverse factors for RFS and DSS included MI ≥50% and adnexal involvement. For OS, there were no statistically significant prognostic factors. In conclusion, MI ≥50% and adnexal involvement are independent prognostic factors for RFS and DSS in G3EEC patients.
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Copy and paste a formatted citation
Spandidos Publications style
Wang J, Jia N, Li Q, Wang C, Tao X, Hua K and Feng W: Analysis of recurrence and survival rates in grade 3 endometrioid endometrial carcinoma. Oncol Lett 12: 2860-2867, 2016.
APA
Wang, J., Jia, N., Li, Q., Wang, C., Tao, X., Hua, K., & Feng, W. (2016). Analysis of recurrence and survival rates in grade 3 endometrioid endometrial carcinoma. Oncology Letters, 12, 2860-2867. https://doi.org/10.3892/ol.2016.4918
MLA
Wang, J., Jia, N., Li, Q., Wang, C., Tao, X., Hua, K., Feng, W."Analysis of recurrence and survival rates in grade 3 endometrioid endometrial carcinoma". Oncology Letters 12.4 (2016): 2860-2867.
Chicago
Wang, J., Jia, N., Li, Q., Wang, C., Tao, X., Hua, K., Feng, W."Analysis of recurrence and survival rates in grade 3 endometrioid endometrial carcinoma". Oncology Letters 12, no. 4 (2016): 2860-2867. https://doi.org/10.3892/ol.2016.4918
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Jia N, Li Q, Wang C, Tao X, Hua K and Feng W: Analysis of recurrence and survival rates in grade 3 endometrioid endometrial carcinoma. Oncol Lett 12: 2860-2867, 2016.
APA
Wang, J., Jia, N., Li, Q., Wang, C., Tao, X., Hua, K., & Feng, W. (2016). Analysis of recurrence and survival rates in grade 3 endometrioid endometrial carcinoma. Oncology Letters, 12, 2860-2867. https://doi.org/10.3892/ol.2016.4918
MLA
Wang, J., Jia, N., Li, Q., Wang, C., Tao, X., Hua, K., Feng, W."Analysis of recurrence and survival rates in grade 3 endometrioid endometrial carcinoma". Oncology Letters 12.4 (2016): 2860-2867.
Chicago
Wang, J., Jia, N., Li, Q., Wang, C., Tao, X., Hua, K., Feng, W."Analysis of recurrence and survival rates in grade 3 endometrioid endometrial carcinoma". Oncology Letters 12, no. 4 (2016): 2860-2867. https://doi.org/10.3892/ol.2016.4918
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