Open Access

Re-irradiation alternatives for recurrent high-grade glioma (Review)

  • Authors:
    • Yuanli Dong
    • Chengrui Fu
    • Hui Guan
    • Tianyi Zhang
    • Zicheng Zhang
    • Tao Zhou
    • Baosheng Li
  • View Affiliations

  • Published online on: August 1, 2016     https://doi.org/10.3892/ol.2016.4926
  • Pages: 2261-2270
  • Copyright: © Dong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Despite advances in the fields of surgery, chemotherapy and radiotherapy, the prognosis for high-grade glioma (HGG) remains unsatisfactory. The majority of HGG patients experience disease recurrence. To date, no standard treatments have been established for recurrent HGG. Repeat surgery and chemotherapy demonstrate moderate efficacy. As recurrent lesions are usually located within the previously irradiated field, a second course of irradiation was once considered controversial, as it was considered to exhibit unsatisfactory efficacy and radiation‑related toxicities. However, an increasing number of studies have indicated that re‑irradiation may present an efficacious treatment for recurrent HGG. Re‑irradiation may be delivered via conventionally fractionated stereotactic radiotherapy, hypofractionated stereotactic radiation therapy, stereotactic radiosurgery and brachytherapy techniques. In the present review, the current literature regarding re‑irradiation treatment for recurrent HGG is summarized with regard to survival outcome and side effects.
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Journal Cover

October-2016
Volume 12 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Dong Y, Fu C, Guan H, Zhang T, Zhang Z, Zhou T and Li B: Re-irradiation alternatives for recurrent high-grade glioma (Review). Oncol Lett 12: 2261-2270, 2016
APA
Dong, Y., Fu, C., Guan, H., Zhang, T., Zhang, Z., Zhou, T., & Li, B. (2016). Re-irradiation alternatives for recurrent high-grade glioma (Review). Oncology Letters, 12, 2261-2270. https://doi.org/10.3892/ol.2016.4926
MLA
Dong, Y., Fu, C., Guan, H., Zhang, T., Zhang, Z., Zhou, T., Li, B."Re-irradiation alternatives for recurrent high-grade glioma (Review)". Oncology Letters 12.4 (2016): 2261-2270.
Chicago
Dong, Y., Fu, C., Guan, H., Zhang, T., Zhang, Z., Zhou, T., Li, B."Re-irradiation alternatives for recurrent high-grade glioma (Review)". Oncology Letters 12, no. 4 (2016): 2261-2270. https://doi.org/10.3892/ol.2016.4926