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Article

Deguelin inhibits proliferation and migration of human pancreatic cancer cells in vitro targeting hedgehog pathway

  • Authors:
    • Wen Zheng
    • Shiliu Lu
    • Haolei Cai
    • Muxing Kang
    • Wenjie Qin
    • Chao Li
    • Yulian Wu
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, The Second Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang 310009, P.R. China
  • Pages: 2761-2765
    |
    Published online on: August 2, 2016
       https://doi.org/10.3892/ol.2016.4928
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Abstract

Pancreatic cancer (PC) is a highly lethal malignancy with few effective therapies. Deguelin, a natural compound of the flavonoid family of products, has been reported to have an inhibitory effect on various cancers. In the present study, we investigated whether deguelin had antitumor efficacy in PC. Deguelin treatment was observed to inhibit growth and induce apoptosis in two PC cell lines (Bxpc‑3 and Panc‑1). In addition, it inhibited migration and invasion in these two cell lines. The activation of the hedgehog (Hh) signaling pathway, as well as matrix metalloproteinases (MMP)-2 and MMP-9, was suppressed by deguelin. These results suggest that deguelin may be a potential chemotherapeutic agent for PC, possibly through the suppression of the Hh signaling pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Zheng W, Lu S, Cai H, Kang M, Qin W, Li C and Wu Y: Deguelin inhibits proliferation and migration of human pancreatic cancer cells in vitro targeting hedgehog pathway. Oncol Lett 12: 2761-2765, 2016.
APA
Zheng, W., Lu, S., Cai, H., Kang, M., Qin, W., Li, C., & Wu, Y. (2016). Deguelin inhibits proliferation and migration of human pancreatic cancer cells in vitro targeting hedgehog pathway. Oncology Letters, 12, 2761-2765. https://doi.org/10.3892/ol.2016.4928
MLA
Zheng, W., Lu, S., Cai, H., Kang, M., Qin, W., Li, C., Wu, Y."Deguelin inhibits proliferation and migration of human pancreatic cancer cells in vitro targeting hedgehog pathway". Oncology Letters 12.4 (2016): 2761-2765.
Chicago
Zheng, W., Lu, S., Cai, H., Kang, M., Qin, W., Li, C., Wu, Y."Deguelin inhibits proliferation and migration of human pancreatic cancer cells in vitro targeting hedgehog pathway". Oncology Letters 12, no. 4 (2016): 2761-2765. https://doi.org/10.3892/ol.2016.4928
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng W, Lu S, Cai H, Kang M, Qin W, Li C and Wu Y: Deguelin inhibits proliferation and migration of human pancreatic cancer cells in vitro targeting hedgehog pathway. Oncol Lett 12: 2761-2765, 2016.
APA
Zheng, W., Lu, S., Cai, H., Kang, M., Qin, W., Li, C., & Wu, Y. (2016). Deguelin inhibits proliferation and migration of human pancreatic cancer cells in vitro targeting hedgehog pathway. Oncology Letters, 12, 2761-2765. https://doi.org/10.3892/ol.2016.4928
MLA
Zheng, W., Lu, S., Cai, H., Kang, M., Qin, W., Li, C., Wu, Y."Deguelin inhibits proliferation and migration of human pancreatic cancer cells in vitro targeting hedgehog pathway". Oncology Letters 12.4 (2016): 2761-2765.
Chicago
Zheng, W., Lu, S., Cai, H., Kang, M., Qin, W., Li, C., Wu, Y."Deguelin inhibits proliferation and migration of human pancreatic cancer cells in vitro targeting hedgehog pathway". Oncology Letters 12, no. 4 (2016): 2761-2765. https://doi.org/10.3892/ol.2016.4928
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