Open Access

Genetic landscape of a case of extraovarian peritoneal serous papillary carcinoma

  • Authors:
    • Zhongping Cheng
    • Weihong Yang
    • Jing Guo
    • Ning Luo
    • Li Chen
    • Yan Xie
    • Xiaoyan Qu
    • Liping Hu
    • Hong Dai
    • Xiaoming Zuo
  • View Affiliations

  • Published online on: August 2, 2016     https://doi.org/10.3892/ol.2016.4933
  • Pages: 2395-2402
  • Copyright: © Cheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present report aimed to study genetic alterations underlying extraovarian peritoneal serous papillary carcinoma (EPSPC), which have not previously been systematically investigated. A case of EPSPC was identified, and its genetic alterations were assessed by combining comparative genomic hybridization and whole-exome sequencing technologies to investigate the genomic landscape, including copy number variations and mutations in EPSPC. It was found that a large number of germline mutations were present, which may have predisposed the patient to the occurrence of this disease. Copy number gains were found in a range of chromosomes, including 4q, 5q, 8q, 10q, 15q, 16p, 18q, 20p, 20q and Xq. Large-scale copy number loss occurred in chromosomes 2p, 13q, 16q, 17p and 17q. Through use of whole‑exome sequencing, germline mutations were widely found that were associated with cancer development, including mutations in the BRCA1, DNA repair associated (BRCA1), BRCA2, tumor protein 53, erb‑b2 receptor tyrosine kinase 2, matrix metalloproteinases and ADAM metallopeptidase domain-containing genes. In addition, 165 somatic mutations, including 52 missense mutations and 7 short insertions or deletions, were also identified. In summary, the EPSPC was undergoing profound genomic rearrangement and somatic mutation, which may have led to its initiation and development, and the present study discussed the genetic basis of this highly malignant cancer.
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October-2016
Volume 12 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Cheng Z, Yang W, Guo J, Luo N, Chen L, Xie Y, Qu X, Hu L, Dai H, Zuo X, Zuo X, et al: Genetic landscape of a case of extraovarian peritoneal serous papillary carcinoma. Oncol Lett 12: 2395-2402, 2016.
APA
Cheng, Z., Yang, W., Guo, J., Luo, N., Chen, L., Xie, Y. ... Zuo, X. (2016). Genetic landscape of a case of extraovarian peritoneal serous papillary carcinoma. Oncology Letters, 12, 2395-2402. https://doi.org/10.3892/ol.2016.4933
MLA
Cheng, Z., Yang, W., Guo, J., Luo, N., Chen, L., Xie, Y., Qu, X., Hu, L., Dai, H., Zuo, X."Genetic landscape of a case of extraovarian peritoneal serous papillary carcinoma". Oncology Letters 12.4 (2016): 2395-2402.
Chicago
Cheng, Z., Yang, W., Guo, J., Luo, N., Chen, L., Xie, Y., Qu, X., Hu, L., Dai, H., Zuo, X."Genetic landscape of a case of extraovarian peritoneal serous papillary carcinoma". Oncology Letters 12, no. 4 (2016): 2395-2402. https://doi.org/10.3892/ol.2016.4933