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Review

Cancer stem cells as a potential therapeutic target in thyroid carcinoma (Review)

  • Authors:
    • Luisa Vicari
    • Cristina Colarossi
    • Dario Giuffrida
    • Ruggero De Maria
    • Lorenzo Memeo
  • View Affiliations / Copyright

    Affiliations: Cell Biology Unit, IOM Ricerca Srl, Viagrande I-95029 Catania, Italy, Department of Experimental Oncology, Mediterranean Institute of Oncology, Viagrande I‑95029 Catania, Italy, Regina Elena National Cancer Institute, I‑00144 Rome, Italy
  • Pages: 2254-2260
    |
    Published online on: August 2, 2016
       https://doi.org/10.3892/ol.2016.4936
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Abstract

A number of studies have indicated that tumor growth and proliferation is dependent on a small subset of cells, defined as cancer stem cells (CSCs). CSCs have the capability to self‑renew, and are involved with cancer propagation, relapse and metastatic dissemination. CSCs have been isolated from numerous tissues, including normal and cancerous thyroid tissue. A regulatory network of signaling pathways and microRNAs (miRNAs) control the properties of CSCs. Differentiated thyroid carcinoma is the most common type of endocrine cancer, with an increasing incidence. Anaplastic thyroid carcinoma is the most rare type of endocrine cancer; however, it also exhibits the highest mortality rate among thyroid malignancies, with an extremely short survival time. Thyroid CSCs are invasive and highly resistant to conventional therapies, including radiotherapy and chemotherapy, which results in disease relapse even when the primary lesion has been eradicated. Therefore, targeting thyroid CSCs may represent an effective treatment strategy against aggressive neoplasms, including recurrent and radioresistant tumors. The present review summarizes the current literature regarding thyroid CSCs and discusses therapeutic strategies that target these cells, with a focus on the function of self‑renewal pathways and miRNAs. Elucidation of the mechanisms that regulate CSC growth and survival may improve novel therapeutic approaches for treatment‑resistant thyroid cancers.
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Copy and paste a formatted citation
Spandidos Publications style
Vicari L, Colarossi C, Giuffrida D, De Maria R and Memeo L: Cancer stem cells as a potential therapeutic target in thyroid carcinoma (Review). Oncol Lett 12: 2254-2260, 2016.
APA
Vicari, L., Colarossi, C., Giuffrida, D., De Maria, R., & Memeo, L. (2016). Cancer stem cells as a potential therapeutic target in thyroid carcinoma (Review). Oncology Letters, 12, 2254-2260. https://doi.org/10.3892/ol.2016.4936
MLA
Vicari, L., Colarossi, C., Giuffrida, D., De Maria, R., Memeo, L."Cancer stem cells as a potential therapeutic target in thyroid carcinoma (Review)". Oncology Letters 12.4 (2016): 2254-2260.
Chicago
Vicari, L., Colarossi, C., Giuffrida, D., De Maria, R., Memeo, L."Cancer stem cells as a potential therapeutic target in thyroid carcinoma (Review)". Oncology Letters 12, no. 4 (2016): 2254-2260. https://doi.org/10.3892/ol.2016.4936
Copy and paste a formatted citation
x
Spandidos Publications style
Vicari L, Colarossi C, Giuffrida D, De Maria R and Memeo L: Cancer stem cells as a potential therapeutic target in thyroid carcinoma (Review). Oncol Lett 12: 2254-2260, 2016.
APA
Vicari, L., Colarossi, C., Giuffrida, D., De Maria, R., & Memeo, L. (2016). Cancer stem cells as a potential therapeutic target in thyroid carcinoma (Review). Oncology Letters, 12, 2254-2260. https://doi.org/10.3892/ol.2016.4936
MLA
Vicari, L., Colarossi, C., Giuffrida, D., De Maria, R., Memeo, L."Cancer stem cells as a potential therapeutic target in thyroid carcinoma (Review)". Oncology Letters 12.4 (2016): 2254-2260.
Chicago
Vicari, L., Colarossi, C., Giuffrida, D., De Maria, R., Memeo, L."Cancer stem cells as a potential therapeutic target in thyroid carcinoma (Review)". Oncology Letters 12, no. 4 (2016): 2254-2260. https://doi.org/10.3892/ol.2016.4936
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