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Article

Tumor‑suppressing effects of microRNA‑429 in human renal cell carcinoma via the downregulation of Sp1

  • Authors:
    • Deyao Wu
    • Xiaobing Niu
    • Huixing Pan
    • Yunfeng Zhou
    • Zichun Zhang
    • Ping Qu
    • Jian Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Urology, The Fourth Affiliated Hospital of Nantong Medical College, Yancheng City No. 1 People's Hospital, Yancheng, Jiangsu 224001, P.R. China, Department of Urology, Huai'An First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu 223300, P.R. China
  • Pages: 2906-2911
    |
    Published online on: August 5, 2016
       https://doi.org/10.3892/ol.2016.4953
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Abstract

MicroRNA (miR)-429 has been frequently reported to be downregulated in various tumors, including renal cell carcinoma (RCC), nasopharyngeal carcinoma, Ehrlich ascites tumor cells, gastric cancer, non‑small cell lung cancer and endometrial endometrioid carcinoma. The present study investigated the effects of miR‑429 on human RCC A498 and 786‑O cells. Following transfection of cells with miR‑429 mimics and scrambled control, MTT, cell migration, cell invasion and luciferase assays were performed. In addition, western blotting was performed in order to assess the expression of specificity protein 1 (Sp1), which was predicted to be a target of miR‑429 by TargetScan. The present results revealed that miR‑429 inhibited cell proliferation, migration and invasion of 786‑O and A498 cells. In addition, the present results demonstrated that miR‑429 overexpression downregulated Sp1 protein expression, which provides evidence that miR‑429 may directly target Sp1 in RCC. These results suggest that miR‑429 may be investigated for use as a predictive marker for early detection of tumor metastasis and blocking RCC cells from becoming invasive.
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View References

1 

Escudier B: Emerging immunotherapies for renal cell carcinoma. Ann Oncol. 23(Suppl 8): viii35–viii40. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Siegel R, Ma J, Zou Z and Jemal A: Cancer statistics, 2014. CA Cancer J Clin. 64:9–29. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Xu S, Wu H, Nie H, Yue L, Jiang H, Xiao S and Li Y: AIF downregulation and its interaction with STK3 in renal cell carcinoma. PLoS One. 9:e1008242014. View Article : Google Scholar : PubMed/NCBI

4 

Srigley JR, Delahunt B, Eble JN, Egevad L, Epstein JI, Grignon D, Hes O, Moch H, Montironi R, Tickoo SK, et al: The international society of urological pathology (ISUP) vancouver classification of renal neoplasia. Am J Surg Pathol. 37:1469–1489. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Yang YQ and Chen J: Predictive role of vascular endothelial growth factor polymorphisms in the survival of renal cell carcinoma patients. Genet Mol Res. 13:5011–5017. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Flanigan RC, Campbell SC, Clark JI and Picken MM: Metastatic renal cell carcinoma. Curr Treat Options Oncol. 4:385–390. 2003. View Article : Google Scholar : PubMed/NCBI

7 

Athar U and Gentile TC: Treatment options for metastatic renal cell carcinoma: A review. Can J Urol. 15:3954–3966. 2008.PubMed/NCBI

8 

Irani J: Sunitinib versus interferon-alpha in metastatic renal-cell carcinoma. Prog Urol. 17:9962007.(In French). View Article : Google Scholar : PubMed/NCBI

9 

Toma MI, Erdmann K, Diezel M, Meinhardt M, Zastrow S, Fuessel S, Wirth MP and Baretton GB: Lack of ephrin receptor A1 is a favorable independent prognostic factor in clear cell renal cell carcinoma. PLoS One. 9:e1022622014. View Article : Google Scholar : PubMed/NCBI

10 

Lai EC: Micro RNAs are complementary to 3′ UTR sequence motifs that mediate negative post-transcriptional regulation. Nat Genet. 30:363–364. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Miao J, Wu S, Peng Z, Tania M and Zhang C: MicroRNAs in osteosarcoma: Diagnostic and therapeutic aspects. Tumour Biol. 34:2093–2098. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Ma XP, Zhang T, Peng B, Yu L and Jiang de K: Association between microRNA polymorphisms and cancer risk based on the findings of 66 case-control studies. PLoS One. 8:e795842013. View Article : Google Scholar : PubMed/NCBI

13 

Berezikov E, Guryev V, van de Belt J, Wienholds E, Plasterk RH and Cuppen E: Phylogenetic shadowing and computational identification of human microRNA genes. Cell. 120:21–24. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Cimmino A, Calin GA, Fabbri M, Iorio MV, Ferracin M, Shimizu M, Wojcik SE, Aqeilan RI, Zupo S, Dono M, et al: miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci USA. 102:13944–13949. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Lee YS and Dutta A: MicroRNAs in cancer. Annu Rev Pathol. 4:199–227. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Xu X, Wu J, Li S, Hu Z, Xu X, Zhu Y, Liang Z, Wang X, Lin Y, Mao Y, et al: Downregulation of microRNA-182-5p contributes to renal cell carcinoma proliferation via activating the AKT/FOXO3a signaling pathway. Mol Cancer. 13:1092014. View Article : Google Scholar : PubMed/NCBI

17 

Bartels CL and Tsongalis GJ: MicroRNAs: Novel biomarkers for human cancer. Ann Biol Clin (Paris). 68:263–272. 2010.(In French). PubMed/NCBI

18 

Sun Y, Shen S, Liu X, Tang H, Wang Z, Yu Z, Li X and Wu M: MiR-429 inhibits cells growth and invasion and regulates EMT-related marker genes by targeting Onecut2 in colorectal carcinoma. Mol Cell Biochem. 390:19–30. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Bartis D, Mise N, Mahida RY, Eickelberg O and Thickett DR: Epithelial-mesenchymal transition in lung development and disease: Does it exist and is it important? Thorax. 69:760–765. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Said NA and Williams ED: Growth factors in induction of epithelial-mesenchymal transition and metastasis. Cells Tissues Organs. 193:85–97. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Yang J and Weinberg RA: Epithelial-mesenchymal transition: At the crossroads of development and tumor metastasis. Dev Cell. 14:818–829. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Zhu W, He J, Chen D, Zhang B, Xu L, Ma H, Liu X, Zhang Y and Le H: Expression of miR-29c, miR-93, and miR-429 as potential biomarkers for detection of early stage non-small lung cancer. PLoS One. 9:e877802014. View Article : Google Scholar : PubMed/NCBI

23 

Miyazono K: Transforming growth factor-beta signaling in epithelial-mesenchymal transition and progression of cancer. Proc Jpn Acad Ser B Phys Biol Sci. 85:314–323. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Wu D, Zhou Y, Pan H, Zhou J, Fan Y and Qu P: microRNA-99a inhibiting cell proliferation, migration and invasion by targeting fibroblast growth factor receptor 3 in bladder cancer. Oncol Lett. 7:1219–1224. 2014.PubMed/NCBI

25 

Hu X, Macdonald DM, Huettner PC, Feng Z, El Naqa IM, Schwarz JK, Mutch DG, Grigsby PW, Powell SN and Wang X: A miR-200 microRNA cluster as prognostic marker in advanced ovarian cancer. Gynecol Oncol. 114:457–464. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Xie P, Xu F, Cheng W, Gao J, Zhang Z, Ge J, Wei Z, Xu X and Liu Y: Infiltration related miRNAs in bladder urothelial carcinoma. J Huazhong Univ Sci Technolog Med Sci. 32:576–580. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Nam EJI, Yoon H, Kim SW, Kim H, Kim YT, Kim JH, Kim JW and Kim S: MicroRNA expression profiles in serous ovarian carcinoma. Clin Cancer Res. 14:2690–2695. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Sun T, Wang C, Xing J and Wu D: miR-429 modulates the expression of c-myc in human gastric carcinoma cells. Eur J Cancer. 47:2552–2559. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Sun Y, Shen S, Tang H, Xiang J, Peng Y, Tang A, Li N, Zhou W, Wang Z, Zhang D, et al: miR-429 identified by dynamic transcriptome analysis is a new candidate biomarker for colorectal cancer prognosis. OMICS. 18:54–64. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Liu X, Liu Y, Wu S, Shi X, Li L, Zhao J and Xu H: Tumor-suppressing effects of miR-429 on human osteosarcoma. Cell Biochem Biophys. 70:215–224. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Ye ZB, Ma G, Zhao YH, Xiao Y, Zhan Y, Jing C, Gao K, Liu ZH and Yu SJ: miR-429 inhibits migration and invasion of breast cancer cells in vitro. Int J Oncol. 46:531–538. 2015.PubMed/NCBI

32 

Wang Y, Li M, Zang W, Ma Y, Wang N, Li P, Wang T and Zhao G: MiR-429 up-regulation induces apoptosis and suppresses invasion by targeting Bcl-2 and SP-1 in esophageal carcinoma. Cell Oncol (Dordr). 36:385–394. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Dynan WS and Tjian R: The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter. Cell. 35:79–87. 1983. View Article : Google Scholar : PubMed/NCBI

34 

Chang WC and Hung JJ: Functional role of post-translational modifications of Sp1 in tumorigenesis. J Biomed Sci. 19:942012. View Article : Google Scholar : PubMed/NCBI

35 

Kadonaga JT, Courey AJ, Ladika J and Tjian R: Distinct regions of Sp1 modulate DNA binding and transcriptional activation. Science. 242:1566–1570. 1988. View Article : Google Scholar : PubMed/NCBI

36 

Philipsen S and Suske G: A tale of three fingers: The family of mammalian Sp/XKLF transcription factors. Nucleic Acids Res. 27:2991–3000. 1999. View Article : Google Scholar : PubMed/NCBI

37 

Narayan VA, Kriwacki RW and Caradonna JP: Structures of zinc finger domains from transcription factor Sp1. Insights into sequence-specific protein-DNA recognition. J Biol Chem. 272:7801–7809. 1997. View Article : Google Scholar : PubMed/NCBI

38 

Black AR, Black JD and Azizkhan-Clifford J: Sp1 and krüppel-like factor family of transcription factors in cell growth regulation and cancer. J Cell Physiol. 188:143–160. 2001. View Article : Google Scholar : PubMed/NCBI

39 

Beishline K and Azizkhan-Clifford J: Sp1 and the ‘Hallmarks of Cancer’. FEBS J. 282:224–258. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Sankpal UT, Goodison S, Abdelrahim M and Basha R: Targeting Sp1 transcription factors in prostate cancer therapy. Med Chem. 7:518–525. 2011. View Article : Google Scholar : PubMed/NCBI

41 

Yue L, Li L, Liu F, Hu N, Zhang W, Bai X, Li Y, Zhang Y, Fu L, Zhang X and Ye L: The oncoprotein HBXIP activates transcriptional coregulatory protein LMO4 via Sp1 to promote proliferation of breast cancer cells. Carcinogenesis. 34:927–935. 2013. View Article : Google Scholar : PubMed/NCBI

42 

Bonofiglio D, Qi H, Gabriele S, Catalano S, Aquila S, Belmonte M and Andò S: Peroxisome proliferator-activated receptor gamma inhibits follicular and anaplastic thyroid carcinoma cells growth by upregulating p21Cip1/WAF1 gene in a Sp1-dependent manner. Endocr Relat Cancer. 15:545–557. 2008. View Article : Google Scholar : PubMed/NCBI

43 

Yin P, Zhao C, Li Z, Mei C, Yao W, Liu Y, Li N, Qi J, Wang L, Shi Y, et al: Sp1 is involved in regulation of cystathionine gamma-lyase gene expression and biological function by PI3K/Akt pathway in human hepatocellular carcinoma cell lines. Cell Signal. 24:1229–1240. 2012. View Article : Google Scholar : PubMed/NCBI

44 

Huang C and Xie K: Crosstalk of Sp1 and Stat3 signaling in pancreatic cancer pathogenesis. Cytokine Growth Factor Rev. 23:25–35. 2012. View Article : Google Scholar : PubMed/NCBI

45 

Pathi S, Jutooru I, Chadalapaka G, Nair V, Lee SO and Safe S: Aspirin inhibits colon cancer cell and tumor growth and downregulates specificity protein (Sp) transcription factors. PLoS One. 7:e482082012. View Article : Google Scholar : PubMed/NCBI

46 

Xu Y, Zhao F, Wang Z, Song Y, Luo Y, Zhang X, Jiang L, Sun Z, Miao Z and Xu H: MicroRNA-335 acts as a metastasis suppressor in gastric cancer by targeting Bcl-w and specificity protein 1. Oncogene. 31:1398–1407. 2012. View Article : Google Scholar : PubMed/NCBI

47 

Wang YT, Chuang JY, Shen MR, Yang WB, Chang WC and Hung JJ: Sumoylation of specificity protein 1 augments its degradation by changing the localization and increasing the specificity protein 1 proteolytic process. J Mol Biol. 380:869–885. 2008. View Article : Google Scholar : PubMed/NCBI

48 

Hsu TI, Wang MC, Chen SY, Yeh YM, Su WC, Chang WC and Hung JJ: Sp1 expression regulates lung tumor progression. Oncogene. 31:3973–3988. 2012. View Article : Google Scholar : PubMed/NCBI

49 

Trisciuoglio D, Iervolino A, Candiloro A, Fibbi G, Fanciulli M, ZangemeisterWittke U, Zupi G and Del Bufalo D: Bcl-2 induction of urokinase plasminogen activator receptor expression in human cancer cells through Sp1 activation: involvement of ERK1/ERK2 activity. J Biol Chem. 279:6737–6745. 2004. View Article : Google Scholar : PubMed/NCBI

50 

DeSiervi A, Marinissen M, Diggs J, Wang XF, Pages G and Senderowicz A: Transcriptional activation of p21 (waf1/cip1) by alkylphospholipids: Role of the mitogen-activated protein kinase pathway in the transactivation of the human p21(waf1/cip1) promoter by Sp1. Cancer Res. 64:743–750. 2004. View Article : Google Scholar : PubMed/NCBI

51 

Wang H, Li M, Zhang R, Wang Y, Zang W, Ma Y, Zhao G and Zhang G: Effect of miR-335 upregulation on the apoptosis and invasion of lung cancer cell A549 and H1299. Tumour Biol. 34:3101–3109. 2013. View Article : Google Scholar : PubMed/NCBI

52 

Jiang J, Lv X, Fan L, Huang G, Zhan Y, Wang M and Lu H: MicroRNA-27b suppresses growth and invasion of NSCLC cells by targeting Sp1. Tumour Biol. 35:10019–10023. 2014. View Article : Google Scholar : PubMed/NCBI

53 

Mao Y, Chen H, Lin Y, Xu X, Hu Z, Zhu Y, Wu J, Xu X, Zheng X and Xie L: microRNA-330 inhibits cell motility by downregulating Sp1 in prostate cancer cells. Oncol Rep. 30:327–333. 2013.PubMed/NCBI

54 

Wang F, Li Y, Zhou J, Xu J, Peng C, Ye F, Shen Y, Lu W, Wan X and Xie X: miR-375 is down-regulated in squamous cervical cancer and inhibits cell migration and invasion via targeting transcription factor SP1. Am J Pathol. 179:2580–2588. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wu D, Niu X, Pan H, Zhou Y, Zhang Z, Qu P and Zhou J: Tumor‑suppressing effects of microRNA‑429 in human renal cell carcinoma via the downregulation of Sp1. Oncol Lett 12: 2906-2911, 2016.
APA
Wu, D., Niu, X., Pan, H., Zhou, Y., Zhang, Z., Qu, P., & Zhou, J. (2016). Tumor‑suppressing effects of microRNA‑429 in human renal cell carcinoma via the downregulation of Sp1. Oncology Letters, 12, 2906-2911. https://doi.org/10.3892/ol.2016.4953
MLA
Wu, D., Niu, X., Pan, H., Zhou, Y., Zhang, Z., Qu, P., Zhou, J."Tumor‑suppressing effects of microRNA‑429 in human renal cell carcinoma via the downregulation of Sp1". Oncology Letters 12.4 (2016): 2906-2911.
Chicago
Wu, D., Niu, X., Pan, H., Zhou, Y., Zhang, Z., Qu, P., Zhou, J."Tumor‑suppressing effects of microRNA‑429 in human renal cell carcinoma via the downregulation of Sp1". Oncology Letters 12, no. 4 (2016): 2906-2911. https://doi.org/10.3892/ol.2016.4953
Copy and paste a formatted citation
x
Spandidos Publications style
Wu D, Niu X, Pan H, Zhou Y, Zhang Z, Qu P and Zhou J: Tumor‑suppressing effects of microRNA‑429 in human renal cell carcinoma via the downregulation of Sp1. Oncol Lett 12: 2906-2911, 2016.
APA
Wu, D., Niu, X., Pan, H., Zhou, Y., Zhang, Z., Qu, P., & Zhou, J. (2016). Tumor‑suppressing effects of microRNA‑429 in human renal cell carcinoma via the downregulation of Sp1. Oncology Letters, 12, 2906-2911. https://doi.org/10.3892/ol.2016.4953
MLA
Wu, D., Niu, X., Pan, H., Zhou, Y., Zhang, Z., Qu, P., Zhou, J."Tumor‑suppressing effects of microRNA‑429 in human renal cell carcinoma via the downregulation of Sp1". Oncology Letters 12.4 (2016): 2906-2911.
Chicago
Wu, D., Niu, X., Pan, H., Zhou, Y., Zhang, Z., Qu, P., Zhou, J."Tumor‑suppressing effects of microRNA‑429 in human renal cell carcinoma via the downregulation of Sp1". Oncology Letters 12, no. 4 (2016): 2906-2911. https://doi.org/10.3892/ol.2016.4953
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