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Article Open Access

Two novel susceptibility loci for non‑small cell lung cancer map to low‑density lipoprotein receptor‑related protein 5

  • Authors:
    • Ying Wang
    • Yongjun Zhang
    • Meiyu Fang
    • Wenglong Bao
    • Dehou Deng
  • View Affiliations / Copyright

    Affiliations: Radiotherapy Department of Gynecological Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China, Department of Integration of Traditional Chinese and Western Medicine, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2307-2318
    |
    Published online on: August 5, 2016
       https://doi.org/10.3892/ol.2016.4954
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Abstract

This study investigated the effect of single‑nucleotide polymorphisms (SNPs) of low‑density lipoprotein receptor‑related protein 5 (LRP5) on the risk of developing non‑small cell lung cancer (NSCLC). A total of 500 NSCLC patients and 500 healthy controls were recruited for genotyping of 11 SNPs of LRP5. The association between genotype and NSCLC risk was evaluated by computing the odds ratio (OR) and 95% confidence interval (CI) from multivariate unconditional logistic regression analyses. Eleven Tag SNPs were detected. The frequency of the LRP5 rs3736228 T allele (18.9% in male NSCLC cases and 23.9% in male controls) was statistically different between male NSCLCs and male controls (P=0.03), and the T allele was associated with a lower risk of NSCLC (OR=0.74; 95% CI, 0.56‑0.67), whereas the C/C homozygous genotype and the LRP5 rs64843 T/T genotype were associated with an increased risk of NSCLC and squamous cell carcinoma (SCC), respectively (OR=1.43 and 1.77, respectively). Using Haploview software, the frequency of the haplotypes of rs312009/rs3120015/rs3120014 CCC was was significantly higher in female SCC cases compared with female controls (0.064 vs. 0.009, P=0.04). LRP5 rs3736228 and rs64843 SNPs were significantly associated with an increased risk of NSCLC and SCC, respectively. Further studies are required to investigate the functional changes in LRP5 expression and activity in NSCLC in vitro.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Zhang Y, Fang M, Bao W and Deng D: Two novel susceptibility loci for non‑small cell lung cancer map to low‑density lipoprotein receptor‑related protein 5. Oncol Lett 12: 2307-2318, 2016.
APA
Wang, Y., Zhang, Y., Fang, M., Bao, W., & Deng, D. (2016). Two novel susceptibility loci for non‑small cell lung cancer map to low‑density lipoprotein receptor‑related protein 5. Oncology Letters, 12, 2307-2318. https://doi.org/10.3892/ol.2016.4954
MLA
Wang, Y., Zhang, Y., Fang, M., Bao, W., Deng, D."Two novel susceptibility loci for non‑small cell lung cancer map to low‑density lipoprotein receptor‑related protein 5". Oncology Letters 12.4 (2016): 2307-2318.
Chicago
Wang, Y., Zhang, Y., Fang, M., Bao, W., Deng, D."Two novel susceptibility loci for non‑small cell lung cancer map to low‑density lipoprotein receptor‑related protein 5". Oncology Letters 12, no. 4 (2016): 2307-2318. https://doi.org/10.3892/ol.2016.4954
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Zhang Y, Fang M, Bao W and Deng D: Two novel susceptibility loci for non‑small cell lung cancer map to low‑density lipoprotein receptor‑related protein 5. Oncol Lett 12: 2307-2318, 2016.
APA
Wang, Y., Zhang, Y., Fang, M., Bao, W., & Deng, D. (2016). Two novel susceptibility loci for non‑small cell lung cancer map to low‑density lipoprotein receptor‑related protein 5. Oncology Letters, 12, 2307-2318. https://doi.org/10.3892/ol.2016.4954
MLA
Wang, Y., Zhang, Y., Fang, M., Bao, W., Deng, D."Two novel susceptibility loci for non‑small cell lung cancer map to low‑density lipoprotein receptor‑related protein 5". Oncology Letters 12.4 (2016): 2307-2318.
Chicago
Wang, Y., Zhang, Y., Fang, M., Bao, W., Deng, D."Two novel susceptibility loci for non‑small cell lung cancer map to low‑density lipoprotein receptor‑related protein 5". Oncology Letters 12, no. 4 (2016): 2307-2318. https://doi.org/10.3892/ol.2016.4954
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