Open Access

Role of Yes-associated protein in cancer: An update (Review)

  • Authors:
    • Ramazan Abylkassov
    • Yingqiu Xie
  • View Affiliations

  • Published online on: August 5, 2016     https://doi.org/10.3892/ol.2016.4955
  • Pages: 2277-2282
  • Copyright: © Abylkassov et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Yes-associated protein (YAP) is an oncoprotein located in the cytoplasm in an inactive form, and when activated, it translocates to the nucleus and activates the transcription of genes responsible for cell division and apoptosis. YAP is one of the downstream regulatory proteins in the Hippo signaling pathway, which is important in cell proliferation and regeneration. Due to its great importance, YAP is regulated very strictly by different regulatory systems. The present review will focus on the canonical pathways of YAP, and will provide details on the most recent findings regarding its regulation and role in tumorigenesis, specifically in prostate tumor progression.
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October-2016
Volume 12 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Abylkassov R and Abylkassov R: Role of Yes-associated protein in cancer: An update (Review). Oncol Lett 12: 2277-2282, 2016
APA
Abylkassov, R., & Abylkassov, R. (2016). Role of Yes-associated protein in cancer: An update (Review). Oncology Letters, 12, 2277-2282. https://doi.org/10.3892/ol.2016.4955
MLA
Abylkassov, R., Xie, Y."Role of Yes-associated protein in cancer: An update (Review)". Oncology Letters 12.4 (2016): 2277-2282.
Chicago
Abylkassov, R., Xie, Y."Role of Yes-associated protein in cancer: An update (Review)". Oncology Letters 12, no. 4 (2016): 2277-2282. https://doi.org/10.3892/ol.2016.4955