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Novel recombinant protein FlaA N/C increases tumor radiosensitivity via NF‑κB signaling in murine breast cancer cells

  • Authors:
    • Ying Xu
    • Dongming Wu
    • Yuanchun Fan
    • Peigeng Li
    • Hongfei Du
    • Jiao Shi
    • Dan Wang
    • Xiaoping Zhou
  • View Affiliations / Copyright

    Affiliations: Clinical Laboratory, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610041, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2632-2640
    |
    Published online on: August 5, 2016
       https://doi.org/10.3892/ol.2016.4957
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Abstract

The recombinant protein flagellin A (FlaA) N/C, derived from the flagellin protein of Legionella pneumophila, has been shown to increase the expression of cytoprotective cytokines, activate the nuclear factor‑κB (NF‑κB) signaling pathway, and increase the survival of mice following total body irradiation. Determi ning whether FlaA N/C has a sensitizing effect on tumor radiation or a direct tumoricidal effect is critical for its application as an effective radiation protection agent. The present study investigated the molecular mechanism underlying the tumor radiosensitivity of FlaA N/C. FlaA N/C was found to increase tumor apoptosis and autophagy, regulate the cell cycle and increase radiosensitivity in 4T1 tumor cells. Furthermore, FlaA N/C was found to promote radiosensitivity by activating NF‑κB signaling. Finally, the present study analyzed FlaA N/C‑enhanced radiosensitivity in animal models, and FlaA N/C was found to significantly prolong the survival period of mice after total body radiation. This indicates that FlaA N/C might be a novel radiation sensitizer in tumor radiation therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Xu Y, Wu D, Fan Y, Li P, Du H, Shi J, Wang D and Zhou X: Novel recombinant protein FlaA N/C increases tumor radiosensitivity via NF‑κB signaling in murine breast cancer cells. Oncol Lett 12: 2632-2640, 2016.
APA
Xu, Y., Wu, D., Fan, Y., Li, P., Du, H., Shi, J. ... Zhou, X. (2016). Novel recombinant protein FlaA N/C increases tumor radiosensitivity via NF‑κB signaling in murine breast cancer cells. Oncology Letters, 12, 2632-2640. https://doi.org/10.3892/ol.2016.4957
MLA
Xu, Y., Wu, D., Fan, Y., Li, P., Du, H., Shi, J., Wang, D., Zhou, X."Novel recombinant protein FlaA N/C increases tumor radiosensitivity via NF‑κB signaling in murine breast cancer cells". Oncology Letters 12.4 (2016): 2632-2640.
Chicago
Xu, Y., Wu, D., Fan, Y., Li, P., Du, H., Shi, J., Wang, D., Zhou, X."Novel recombinant protein FlaA N/C increases tumor radiosensitivity via NF‑κB signaling in murine breast cancer cells". Oncology Letters 12, no. 4 (2016): 2632-2640. https://doi.org/10.3892/ol.2016.4957
Copy and paste a formatted citation
x
Spandidos Publications style
Xu Y, Wu D, Fan Y, Li P, Du H, Shi J, Wang D and Zhou X: Novel recombinant protein FlaA N/C increases tumor radiosensitivity via NF‑κB signaling in murine breast cancer cells. Oncol Lett 12: 2632-2640, 2016.
APA
Xu, Y., Wu, D., Fan, Y., Li, P., Du, H., Shi, J. ... Zhou, X. (2016). Novel recombinant protein FlaA N/C increases tumor radiosensitivity via NF‑κB signaling in murine breast cancer cells. Oncology Letters, 12, 2632-2640. https://doi.org/10.3892/ol.2016.4957
MLA
Xu, Y., Wu, D., Fan, Y., Li, P., Du, H., Shi, J., Wang, D., Zhou, X."Novel recombinant protein FlaA N/C increases tumor radiosensitivity via NF‑κB signaling in murine breast cancer cells". Oncology Letters 12.4 (2016): 2632-2640.
Chicago
Xu, Y., Wu, D., Fan, Y., Li, P., Du, H., Shi, J., Wang, D., Zhou, X."Novel recombinant protein FlaA N/C increases tumor radiosensitivity via NF‑κB signaling in murine breast cancer cells". Oncology Letters 12, no. 4 (2016): 2632-2640. https://doi.org/10.3892/ol.2016.4957
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