Association of FOXM1 expression with tumor histology and prognosis in Wilms tumor: Potential for a new prognostic marker

Apelt,Nadja; Hubertus,Jochen; Mayr,Doris; Graf,Norbert; Furtwängler,Rhoikos; Von Schweinitz,Dietrich; Kappler,Roland

doi:10.3892/ol.2016.4958

October-2016 Volume 12 Issue 4

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October-2016 Volume 12 Issue 4

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Article

Association of FOXM1 expression with tumor histology and prognosis in Wilms tumor: Potential for a new prognostic marker

Authors:
- Nadja Apelt
- Jochen Hubertus
- Doris Mayr
- Norbert Graf
- Rhoikos Furtwängler
- Dietrich Von Schweinitz
- Roland Kappler
View Affiliations / Copyright

Affiliations: Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, Ludwig Maximilian University of Munich, Munich, 80337 Bavaria, Germany, Institute of Pathology, Ludwig Maximilian University of Munich, Munich, 80337 Bavaria, Germany, Department of Pediatric Oncology and Hematology, University of Saarland, Homburg, 66421 Saarland, Germany
Pages: 2854-2859
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Published online on: August 5, 2016

https://doi.org/10.3892/ol.2016.4958
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Abstract

Wilms tumor (WT) is the most common pediatric renal malignancy. A recent ontogenic model suggests that undifferentiated tumor state, and hence poor prognosis, in WT is determined by stabilization of β‑catenin in the nucleus. Forkhead box M1 (FOXM1) is a downstream component of the Wnt pathway and promotes nuclear localization of β‑catenin. As elevation of FOXM1 gene expression is prognostic in various types of malignancy, we hypothesized that high FOXM1 expression in WT is associated with undifferentiated histology and thus poor prognosis. In the current study, the expression of FOXM1 mRNA was determined in 46 WT specimens and 11 renal tissue controls from patients undergoing tumor nephrectomy, and these data were assessed with regard to clinicopathological parameters. The results demonstrated an upregulation of FOXM1 in WT by 10‑fold compared to normal tissue. Expression differed significantly between controls and tumors of intermediate‑ and high‑risk histopathology (P<0.001, Kruskal‑Wallis), and distinguished normal tissue from tumors of good and adverse clinical outcome (P<0.001, Kruskal‑Wallis). Notably, FOXM1 expression was significantly lower (P=0.009) in patients that received preoperative doxorubicin. These results suggest that FOXM1 may serve as a companion diagnostic factor for doxorubicin‑based therapies in WT.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Association of FOXM1 expression with tumor histology and prognosis in Wilms tumor: Potential for a new prognostic marker

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