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Prognostic significance of CD168 overexpression in colorectal cancer

  • Authors:
    • Ke Wang
    • Tao Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Cancer Institute, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China, Department of Preventive and Health Care, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2555-2559
    |
    Published online on: August 8, 2016
       https://doi.org/10.3892/ol.2016.4974
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Abstract

The expression of cluster of differentiation 168 (CD168), a cell surface receptor for hyaluronan, is associated with cancer progression and metastases. The aim of the present study was to analyze the expression of CD168 by immunohistochemistry in colorectal cancer (CRC) and to examine the association between CD168 expression and clinicopathological features, including survival. A total of 78 tissue specimens obtained from consecutive CRC patients exhibiting various tumor node metastasis (TNM) stages were immunostained for the analysis of CD168 expression. The prognostic value of CD168 was subsequently evaluated. Kaplan‑Meier survival analysis revealed that CD168 overexpression was significantly associated with overall survival (P<0.05); however, no significant association was identified between CD168 expression and tumor location, tumor differentiation or TNM stage. Overexpression of CD168 was closely associated with poorer patient survival, which indicates that it may present a useful indicator for clinical prognosis.
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Copy and paste a formatted citation
Spandidos Publications style
Wang K and Zhang T: Prognostic significance of CD168 overexpression in colorectal cancer. Oncol Lett 12: 2555-2559, 2016.
APA
Wang, K., & Zhang, T. (2016). Prognostic significance of CD168 overexpression in colorectal cancer. Oncology Letters, 12, 2555-2559. https://doi.org/10.3892/ol.2016.4974
MLA
Wang, K., Zhang, T."Prognostic significance of CD168 overexpression in colorectal cancer". Oncology Letters 12.4 (2016): 2555-2559.
Chicago
Wang, K., Zhang, T."Prognostic significance of CD168 overexpression in colorectal cancer". Oncology Letters 12, no. 4 (2016): 2555-2559. https://doi.org/10.3892/ol.2016.4974
Copy and paste a formatted citation
x
Spandidos Publications style
Wang K and Zhang T: Prognostic significance of CD168 overexpression in colorectal cancer. Oncol Lett 12: 2555-2559, 2016.
APA
Wang, K., & Zhang, T. (2016). Prognostic significance of CD168 overexpression in colorectal cancer. Oncology Letters, 12, 2555-2559. https://doi.org/10.3892/ol.2016.4974
MLA
Wang, K., Zhang, T."Prognostic significance of CD168 overexpression in colorectal cancer". Oncology Letters 12.4 (2016): 2555-2559.
Chicago
Wang, K., Zhang, T."Prognostic significance of CD168 overexpression in colorectal cancer". Oncology Letters 12, no. 4 (2016): 2555-2559. https://doi.org/10.3892/ol.2016.4974
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