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Article

Impact of intense systemic therapy and improved survival on the use of palliative radiotherapy in patients with bone metastases from prostate cancer

  • Authors:
    • Carsten Nieder
    • Ellinor Haukland
    • Bård Mannsåker
    • Jan Norum
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø ‑ The Arctic University of Norway, 9037 Tromsø, Norway, Department of Oncology and Palliative Medicine, Nordland Hospital, 8092 Bodø, Norway
  • Pages: 2930-2935
    |
    Published online on: August 12, 2016
       https://doi.org/10.3892/ol.2016.5003
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Abstract

More effective drugs may reduce the requirement for palliative external beam radiotherapy for bony target volumes; however, living with metastases for prolonged periods of time may result in more frequent episodes of bone pain or serious skeletal‑related events. The purpose of the present study was to evaluate how recent advances in systemic therapy impact radiotherapy utilization. A retrospective analysis of a comprehensive regional database was performed. All oncology care in this region was provided by only one center, assuring complete data. Patients that had succumbed between June 1, 2004 and June 1, 2015 were included. For all 236 patients, the median age at diagnosis of bone metastases was 75 years and median overall survival was 20 months. More intense systemic therapy was associated with a significantly longer survival time. Only 69 patients (29%) did not receive palliative radiotherapy for bony target volumes, whilst 1 course was given to 101 patients (43%), 2 courses to 34 patients (14%) and >2 courses to 32 patients (14%). Radiotherapy was used more frequently in younger patients, those with spinal cord compressions or pathological fractures, and those treated with intense and long‑standing systemic therapy. Radiotherapy utilization increased with survival time. For 100 poor‑prognosis patients that succumbed within 12 months, 57 courses of palliative radiotherapy were administered, whilst 100 patients that survived for 12‑24 months were administered 114 courses (24‑36 months, 148 courses). In conclusion, the use of palliative radiotherapy did not decrease when more effective systemic therapy was administered. However, provided that only 5% of patients received radionuclide treatment, additional studies in other populations are required.
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1 

Gartrell BA, Coleman R, Efstathiou E, Fizazi K, Logothetis CJ, Smith MR, Sonpavde G, Sartor O and Saad F: Metastatic prostate cancer and the bone: Significance and therapeutic options. Eur Urol. 68:850–858. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Crawford ED, Higano CS, Shore ND, Hussain M and Petrylak DP: Treating patients with metastatic castration resistant prostate cancer: A comprehensive review of available therapies. J Urol. 194:1537–1547. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Halabi S, Kelly WK, Ma H, Zhou H, Solomon NC, Fizazi K, Tangen CM, Rosenthal M, Petrylak DP, Hussain M, et al: Meta-analysis evaluating the impact of site of metastasis on overall survival in men with castration-resistant prostate cancer. J Clin Oncol. 34:1652–1659. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Oster G, Lamerato L, Glass AG, Richert-Boe KE, Lopez A, Chung K, Richhariya A, Dodge T, Wolff GG, Balakumaran A and Edelsberg J: Natural history of skeletal-related events in patients with breast, lung, or prostate cancer and metastases to bone: a 15-year study in two large US health systems. Support Care Cancer. 21:3279–3286. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Borras JM, Lievens Y, Dunscombe P, Coffey M, Malicki J, Corral J, Gasparotto C, Defourny N, Barton M, Verhoeven R, et al: The optimal utilization proportion of external beam radiotherapy in European countries: An ESTRO-HERO analysis. Radiother Oncol. 116:38–44. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Borras JM, Barton M, Grau C, Corral J, Verhoeven R, Lemmens V, van Eycken L, Henau K, Primic-Zakelj M, Strojan P, et al: The impact of cancer incidence and stage on optimal utilization of radiotherapy: Methodology of a population based analysis by the ESTRO-HERO project. Radiother Oncol. 116:45–50. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Nieder C, Pawinski A, Haukland E, Dokmo R, Phillipi I and Dalhaug A: Estimating need for palliative external beam radiotherapy in adult cancer patients. Int J Radiat Oncol Biol Phys. 76:207–211. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Norwegian Directorate of Health, Oslo, . 2015, National care program with guidelines for the examinations, treatments and follow up of patients with prostate cancer. https://helsedirektoratet.no/Documents/Utgåtte%20publikasjoner/IS-1777%20(1)%20Prostatakreft%2017.12.09-16-10.12.pdfAccessed on June 26, 2016. (In Norwegian).

9 

Tannock IF, de Wit R, Berry WR, Horti J, Pluzanska A, Chi KN, Oudard S, Théodore C, James ND, Turesson I, et al: Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer. N Engl J Med. 351:1502–1512. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Zielinski RR, Azad AA, Chi KN and Tyldesely S: Population-based impact on overall survival after the introduction of docetaxel as standard therapy for metastatic castration resistant prostate cancer. Can Urol Assoc J. 8:E520–E523. 2014. View Article : Google Scholar : PubMed/NCBI

11 

deBono JS, Oudard S, Ozguroglu M, Hansen S, Machiels JP, Kocak I, Gravis G, Bodrogi I, Mackenzie MJ, Shen L, et al: Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: A randomised open-label trial. Lancet. 376:1147–1154. 2010. View Article : Google Scholar : PubMed/NCBI

12 

deBono JS, Logothetis CJ, Molina A, Fizazi K, North S, Chu L, Chi KN, Jones RJ, Goodman OB Jr, Saad F, et al: Abiraterone and increased survival in metastatic prostate cancer. N Engl J Med. 364:1995–2005. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Ryan CJ, Smith MR, Fizazi K, Saad F, Mulders PF, Sternberg CN, Miller K, Logothetis CJ, Shore ND, Small EJ, et al: Abiraterone acetate plus prednisone versus placebo plus prednisone in chemotherapy-naive men with metastatic castration-resistant prostate cancer (COU-AA-302): Final overall survival analysis of a randomised, double-blind, placebo-controlled phase 3 study. Lancet Oncol. 16:152–160. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Scher HI, Fizazi K, Saad F, Taplin ME, Sternberg CN, Miller K, de Wit R, Mulders P, Chi KN, Shore ND, et al: Increased survival with enzalutamide in prostate cancer after chemotherapy. N Engl J Med. 367:1187–1197. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Loriot Y, Miller K, Sternberg CN, Fizazi K, De Bono JS, Chowdhury S, Higano CS, Noonberg S, Holmstrom S, Mansbach H, et al: Effect of enzalutamide on health-related quality of life, pain, and skeletal-related events in asymptomatic and minimally symptomatic, chemotherapy-naive patients with metastatic castration-resistant prostate cancer (PREVAIL): Results from a randomised, phase 3 trial. Lancet Oncol. 16:509–521. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Murphy JD, Nelson LM, Chang DT, Mell LK and Le QT: Patterns of care in palliative radiotherapy: A population-based study. J Oncol Pract. 9:e220–e227. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Fizazi K, Carducci M, Smith M, Damião R, Brown J, Karsh L, Milecki P, Shore N, Rader M, Wang H, et al: Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: A randomised, double-blind study. Lancet. 377:813–822. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Parker C, Nilsson S, Heinrich D, Helle SI, O'Sullivan JM, Fosså SD, Chodacki A, Wiechno P, Logue J, Seke M, et al: Alpha emitter radium-223 and survival in metastatic prostate cancer. N Engl J Med. 369:213–223. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Jong JM, Oprea-Lager DE, Hooft L, de Klerk JM, Bloemendal HJ, Verheul HM, Hoekstra OS and van den Eertwegh AJ: Radiopharmaceuticals for palliation of bone pain in patients with castration-resistant prostate cancer metastatic to bone: A systematic review. Eur Urol. pii:S0302–2838, 00862-00863. 2015.

20 

Norum J, Traasdahl ER, Totth A, Nieder C and Olsen JA: Health economics and radium-223 (Xofigo®) in the treatment of metastatic castration resistant prostate cancer (mCRPC): A case history and a systematic review of the literature. Glob J Health Sci. 8:1–9. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Sweeney CJ, Chen YH, Carducci M, Liu G, Jarrard DF, Eisenberger M, Wong YN, Hahn N, Kohli M, Cooney MM, et al: Chemohormonal therapy in metastatic hormone-sensitive prostate cancer. N Engl J Med. 373:737–746. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Nieder C, Haukland E, Mannsåker B and Norum J: Impact of intense systemic therapy and improved survival on the use of palliative radiotherapy in patients with bone metastases from prostate cancer. Oncol Lett 12: 2930-2935, 2016.
APA
Nieder, C., Haukland, E., Mannsåker, B., & Norum, J. (2016). Impact of intense systemic therapy and improved survival on the use of palliative radiotherapy in patients with bone metastases from prostate cancer. Oncology Letters, 12, 2930-2935. https://doi.org/10.3892/ol.2016.5003
MLA
Nieder, C., Haukland, E., Mannsåker, B., Norum, J."Impact of intense systemic therapy and improved survival on the use of palliative radiotherapy in patients with bone metastases from prostate cancer". Oncology Letters 12.4 (2016): 2930-2935.
Chicago
Nieder, C., Haukland, E., Mannsåker, B., Norum, J."Impact of intense systemic therapy and improved survival on the use of palliative radiotherapy in patients with bone metastases from prostate cancer". Oncology Letters 12, no. 4 (2016): 2930-2935. https://doi.org/10.3892/ol.2016.5003
Copy and paste a formatted citation
x
Spandidos Publications style
Nieder C, Haukland E, Mannsåker B and Norum J: Impact of intense systemic therapy and improved survival on the use of palliative radiotherapy in patients with bone metastases from prostate cancer. Oncol Lett 12: 2930-2935, 2016.
APA
Nieder, C., Haukland, E., Mannsåker, B., & Norum, J. (2016). Impact of intense systemic therapy and improved survival on the use of palliative radiotherapy in patients with bone metastases from prostate cancer. Oncology Letters, 12, 2930-2935. https://doi.org/10.3892/ol.2016.5003
MLA
Nieder, C., Haukland, E., Mannsåker, B., Norum, J."Impact of intense systemic therapy and improved survival on the use of palliative radiotherapy in patients with bone metastases from prostate cancer". Oncology Letters 12.4 (2016): 2930-2935.
Chicago
Nieder, C., Haukland, E., Mannsåker, B., Norum, J."Impact of intense systemic therapy and improved survival on the use of palliative radiotherapy in patients with bone metastases from prostate cancer". Oncology Letters 12, no. 4 (2016): 2930-2935. https://doi.org/10.3892/ol.2016.5003
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