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Article Open Access

Bioinformatics analysis of the molecular mechanism of diffuse intrinsic pontine glioma

  • Authors:
    • Lei Deng
    • Pengju Xiong
    • Yunhui Luo
    • Xiao Bu
    • Suokai Qian
    • Wuzhao Zhong
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, The Great Wall Hospital Affiliated to Nanchang University, 94th Hospital of the People's Liberation Army, Nanchang, Jiangxi 30002, P.R. China
    Copyright: © Deng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2524-2530
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    Published online on: August 16, 2016
       https://doi.org/10.3892/ol.2016.5024
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Abstract

The present study aimed to elucidate key molecular mechanisms in the progression of diffuse intrinsic pontine glioma (DIPG). The gene expression profile GSE50021, which consisted of 35 pediatric DIPG samples and 10 normal brain samples, was downloaded from the Gene Expression Omnibus database. The differentially‑expressed genes (DEGs) in the pediatric DIPG samples were identified. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) and Reactome pathways of DEGs were enriched and analyzed. The protein‑protein interaction (PPI) network of the DEGs was constructed and functional modules of the PPI network were disclosed using ClusterONE. A total of 679 DEGs (454 up‑ and 225 downregulated) were identified in the pediatric DIPG samples. DEGs were significantly enriched in various GO terms, and KEGG and Reactome pathways. The PPI network of upregulated (153 nodes and 298 connections) and downregulated (71 nodes and 124 connections) DEGs, and two crucial modules, were obtained. Downregulated genes in module 2, such as cholecystokinin (CCK), gastrin (GAST), adenylate cyclase 2 (brain) (ADCY2) and 5‑hydroxytryptamine (serotonin) receptor 7 (HTR7), were significantly enriched in the calcium signaling pathway, the neuroactive ligand‑receptor interaction pathway and in GO terms, such as the G‑protein coupled receptor (GPCR) signaling pathway, while upregulated genes in module 1 were not enriched in any pathways or GO terms. CCK and GAST associated with the GPCR signaling pathway, HTR7 enriched in the neuroactive ligand‑receptor interaction, and ADCY2 and HTR7 involved in the calcium signaling pathway may be key mechanisms playing crucial roles in the development and progression of DIPG.
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1 

Hargrave D, Bartels U and Bouffet E: Diffuse brainstem glioma in children: Critical review of clinical trials. Lancet Oncol. 7:241–248. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Puget S, Philippe C, Bax DA, Job B, Varlet P, Junier MP, Andreiuolo F, Carvalho D, Reis R, Guerrini-Rousseau L, et al: Mesenchymal transition and PDGFRA amplification/mutation are key distinct oncogenic events in pediatric diffuse intrinsic pontine gliomas. PLoS One. 7:e303132012. View Article : Google Scholar : PubMed/NCBI

3 

Donaldson SS, Laningham F and Fisher PG: Advances toward an understanding of brainstem gliomas. J Clin Oncol. 24:1266–1272. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Paugh BS, Broniscer A, Qu C, Miller CP, Zhang J, Tatevossian RG, Olson JM, Geyer JR, Chi SN, da Silva NS, et al: Genome-wide analyses identify recurrent amplifications of receptor tyrosine kinases and cell-cycle regulatory genes in diffuse intrinsic pontine glioma. J Clin Oncol. 29:3999–4006. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Wu G, Broniscer A, McEachron TA, Lu C, Paugh BS, Becksfort J, Qu C, Ding L, Huether R, Parker M, et al: Project SJCsRHWUPCG: Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas. Nat Genet. 44:251–253. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Buczkowicz P, Hoeman C, Rakopoulos P, Pajovic S, Letourneau L, Dzamba M, Morrison A, Lewis P, Bouffet E, Bartels U, et al: Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations. Nat Genet. 46:451–456. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Kurooka H, Nakahiro T, Mori K, Sano K and Yokota Y: BMP signaling is responsible for serum-induced Id2 expression. Biochem Biophys Res Commun. 420:281–287. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Kowanetz M, Valcourt U, Bergström R, Heldin CH and Moustakas A: Id2 and Id3 define the potency of cell proliferation and differentiation responses to transforming growth factor beta and bone morphogenetic protein. Mol Cell Biol. 24:4241–4254. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Shin M, Ohte S, Fukuda T, Sasanuma H, Yoneyama K, Kokabu S, Miyamoto A, Tsukamoto S, Hohjoh H, Jimi E and Katagiri T: Identification of a novel bone morphogenetic protein (BMP)-inducible transcript, BMP-inducible transcript-1, by utilizing the conserved BMP-responsive elements in the Id genes. J Bone Miner Metab. 31:34–43. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Piccirillo S, Reynolds B, Zanetti N, Lamorte G, Binda E, Broggi G, Brem H, Olivi A, Dimeco F and Vescovi AL: Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells. Nature. 444:761–765. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Lee J, Son MJ, Woolard K, Donin NM, Li A, Cheng CH, Kotliarova S, Kotliarov Y, Walling J, Ahn S, et al: Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells. Cancer Cell. 13:69–80. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Wu G, Diaz AK, Paugh BS, Rankin SL, Ju B, Li Y, Zhu X, Qu C, Chen X, Zhang J, et al: St. Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project: The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma. Nat Genet. 46:444–450. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Taylor KR, Mackay A, Truffaux N, Butterfield YS, Morozova O, Philippe C, Castel D, Grasso CS, Vinci M, Carvalho D, et al: Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma. Nat Genet. 46:457–461. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Zarghooni M, Bartels U, Lee E, Buczkowicz P, Morrison A, Huang A, Bouffet E and Hawkins C: Whole-genome profiling of pediatric diffuse intrinsic pontine gliomas highlights platelet-derived growth factor receptor alpha and poly (ADP-ribose) polymerase as potential therapeutic targets. J Clin Oncol. 28:1337–1344. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U and Speed TP: Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics. 4:249–264. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Smyth GK: Limma: Linear models for microarray dataBioinformatics and Computational Biology Solutions using R and Bioconductor. Gentleman R, Carey VJ, Huber W, Irizarry RA and Dudoit S: Springer-Verlag; New York: pp. 397–420. 2005, View Article : Google Scholar

17 

Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al: Gene ontology: Tool for the unification of biology. The gene ontology constortium. Nat Genet. 25:25–29. 2000. View Article : Google Scholar : PubMed/NCBI

18 

Kanehisa M and Goto S: KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28:27–30. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Croft D, O'Kelly G, Wu G, Haw R, Gillespie M, Matthews L, Caudy M, Garapati P, Gopinath G, Jassal B, et al: Reactome: A database of reactions, pathways and biological processes. Nucleic Acids Res. 39:(Database Issue). D691–D697. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Huangda W, Sherman BT and Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 4:44–57. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Zhao M, Sun J and Zhao Z: TSGene: A web resource for tumor suppressor genes. Nucleic Acids Res. 41:(Database Issue). D970–D976. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Chen JS, Hung WS, Chan HH, Tsai SJ and Sun HS: In silico identification of oncogenic potential of fyn-related kinase in hepatocellular carcinoma. Bioinformatics. 29:420–427. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Franceschini A, Szklarczyk D, Frankild S, Kuhn M, Simonovic M, Roth A, Lin J, Minguez P, Bork P, von Mering C and Jensen LJ: STRING v9. 1: Protein-protein interaction networks, with increased coverage and integration. Nucleic Acids Res. 41:(Database Issue). D808–D815. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Smoot ME, Ono K, Ruscheinski J, Wang PL and Ideker T: Cytoscape 2.8: New features for data integration and network visualization. Bioinformatics. 27:431–432. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Maraziotis IA, Dimitrakopoulou K and Bezerianos A: An in silico method for detecting overlapping functional modules from composite biological networks. BMC Syst Biol. 2:932008. View Article : Google Scholar : PubMed/NCBI

26 

Saratsis AM, Yadavilli S, Magge S, Rood BR, Perez J, Hill DA, Hwang E, Kilburn L, Packer RJ and Nazarian J: Insights into pediatric diffuse intrinsic pontine glioma through proteomic analysis of cerebrospinal fluid. Neuro Oncol. 14:547–560. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Rehfeld JF, Friis-Hansen L, Goetze JP and Hansen TV: The biology of cholecystokinin and gastrin peptides. Curr Top Med Chem. 7:1154–1165. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Lefranc F, Camby I, Belot N, Bruyneel E, Chaboteaux C, Brotchi J, Mareel M, Salmon I and Kiss R: Gastrin significantly modifies the migratory abilities of experimental glioma cells. Lab Invest. 82:1241–1252. 2002. View Article : Google Scholar : PubMed/NCBI

29 

Oikonomou E, Buchfelder M and Adams EF: Cholecystokinin (CCK) and CCK receptor expression by human gliomas: Evidence for an autocrine/paracrine stimulatory loop. Neuropeptides. 42:255–265. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Dmitrenko V, Bojko O, Shostak K, Vitak NY, Bukreeva T, Rozumenko V, Malysheva T, Shamayev M, Zozulya YP and Kavsan VM: Characterization of genes, down-regulated in human glioma, potential tumor suppressor genes. Biopolym Cell. 23:347–362. 2007. View Article : Google Scholar

31 

Harmar AJ: Family-B G-protein-coupled receptors. Genome Biol. 2:REVIEWS30132001. View Article : Google Scholar : PubMed/NCBI

32 

Shu M, Zhou Y, Zhu W, Zhang H, Wu S, Chen J and Yan G: MicroRNA 335 is required for differentiation of malignant glioma cells induced by activation of cAMP/protein kinase A pathway. Mol Pharmacol. 81:292–298. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Smith AM and Watson SA: Gastrin and gastrin receptor activation: An early event in the adenoma-carcinoma sequence. Gut. 47:820–824. 2000. View Article : Google Scholar : PubMed/NCBI

34 

Paillasse MR, de Medina P, Amouroux G, Mhamdi L, Poirot M and Silvente-Poirot S: Signaling through cholesterol esterification: A new pathway for the cholecystokinin 2 receptor involved in cell growth and invasion. J Lipid Res. 50:2203–2211. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Oswald P, Souery D and Mendlewicz J: Molecular genetics of affective disorders. Int J Neuropsychopharmacol. 6:155–169. 2003. View Article : Google Scholar : PubMed/NCBI

36 

Jones C, Perryman L and Hargrave D: Paediatric and adult malignant glioma: Close relatives or distant cousins? Nat Rev Clin Oncol. 9:400–413. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Chan KM, Fang D, Gan H, Hashizume R, Yu C, Schroeder M, Gupta N, Mueller S, James CD, Jenkins R, et al: The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression. Genes Dev. 27:985–990. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Monteith GR, McAndrew D, Faddy HM and Roberts-Thomson SJ: Calcium and cancer: Targeting Ca2+ transport. Nat Rev Cancer. 7:519–530. 2007. View Article : Google Scholar : PubMed/NCBI

39 

Kang SS, Han KS, Ku BM, Lee YK, Hong J, Shin HY, Almonte AG, Woo DH, Brat DJ, Hwang EM, et al: Caffeine-mediated inhibition of calcium release channel inositol 1,4,5-trisphosphate receptor subtype 3 blocks glioblastoma invasion and extends survival. Cancer Res. 70:1173–1183. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Ludwig MG and Seuwen K: Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms. J Recept Signal Transduct Res. 22:79–110. 2002. View Article : Google Scholar : PubMed/NCBI

41 

Hagan JJ, Price GW, Jeffrey P, Deeks NJ, Stean T, Piper D, Smith MI, Upton N, Medhurst AD, Middlemiss DN, et al: Characterization of SB-269970-A, a selective 5-HT(7) receptor antagonist. Br J Pharmacol. 130:539–548. 2000. View Article : Google Scholar : PubMed/NCBI

42 

Zhang HT, Huang Y, Jin SL, Frith SA, Suvarna N, Conti M and O'Donnell JM: Antidepressant-like profile and reduced sensitivity to rolipram in mice deficient in the PDE4D phosphodiesterase enzyme. Neuropsychopharmacology. 27:587–595. 2002.PubMed/NCBI

43 

Schmidt M, Evellin S, Weernink PA, von Dorp F, Rehmann H, Lomasney JW and Jakobs KH: A new phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase. Nat Cell Biol. 3:1020–1024. 2001. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Deng L, Xiong P, Luo Y, Bu X, Qian S and Zhong W: Bioinformatics analysis of the molecular mechanism of diffuse intrinsic pontine glioma. Oncol Lett 12: 2524-2530, 2016.
APA
Deng, L., Xiong, P., Luo, Y., Bu, X., Qian, S., & Zhong, W. (2016). Bioinformatics analysis of the molecular mechanism of diffuse intrinsic pontine glioma. Oncology Letters, 12, 2524-2530. https://doi.org/10.3892/ol.2016.5024
MLA
Deng, L., Xiong, P., Luo, Y., Bu, X., Qian, S., Zhong, W."Bioinformatics analysis of the molecular mechanism of diffuse intrinsic pontine glioma". Oncology Letters 12.4 (2016): 2524-2530.
Chicago
Deng, L., Xiong, P., Luo, Y., Bu, X., Qian, S., Zhong, W."Bioinformatics analysis of the molecular mechanism of diffuse intrinsic pontine glioma". Oncology Letters 12, no. 4 (2016): 2524-2530. https://doi.org/10.3892/ol.2016.5024
Copy and paste a formatted citation
x
Spandidos Publications style
Deng L, Xiong P, Luo Y, Bu X, Qian S and Zhong W: Bioinformatics analysis of the molecular mechanism of diffuse intrinsic pontine glioma. Oncol Lett 12: 2524-2530, 2016.
APA
Deng, L., Xiong, P., Luo, Y., Bu, X., Qian, S., & Zhong, W. (2016). Bioinformatics analysis of the molecular mechanism of diffuse intrinsic pontine glioma. Oncology Letters, 12, 2524-2530. https://doi.org/10.3892/ol.2016.5024
MLA
Deng, L., Xiong, P., Luo, Y., Bu, X., Qian, S., Zhong, W."Bioinformatics analysis of the molecular mechanism of diffuse intrinsic pontine glioma". Oncology Letters 12.4 (2016): 2524-2530.
Chicago
Deng, L., Xiong, P., Luo, Y., Bu, X., Qian, S., Zhong, W."Bioinformatics analysis of the molecular mechanism of diffuse intrinsic pontine glioma". Oncology Letters 12, no. 4 (2016): 2524-2530. https://doi.org/10.3892/ol.2016.5024
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