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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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October-2016 Volume 12 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Case Report

IgM multiple myeloma with an extremely rare non‑aggressive presentation: A case report

  • Authors:
    • Thomas Greuter
    • Martin Browne
    • Corina Dommann‑Scherrer
    • Daniel Binder
    • Christoph Renner
    • Ursula Kapp
  • View Affiliations / Copyright

    Affiliations: Department of Medicine, GZO‑Zurich Regional Health Center, 8620 Wetzikon, Zurich, Switzerland, North Coast Cancer Institute, Coffs Harbour Health Campus, Coffs Harbour, New South Wales 2450, Australia, Division of Hematology, Cantonal Hospital Winterthur, 8401 Winterthur, Zurich, Switzerland, Oncology Centre, Hirslanden Clinic, 8032 Zurich, Switzerland
  • Pages: 2801-2803
    |
    Published online on: August 17, 2016
       https://doi.org/10.3892/ol.2016.5034
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Abstract

In the present study, the case of a 41‑year‑old man with immunoglobulin (Ig)M multiple myeloma (MM) that presented with an unusually non‑aggressive clinical course who has survived for >9 years to date, is presented. Initial diagnosis of symptomatic MM was established according to the International Myeloma Working Group consensus statement and guidelines. Due to the mild symptoms, no therapy was administered and the patient was closely followed up. Eight years after initial diagnosis, clinical, morphological and genetic progression occurred with the development of hypercalcemia, progressively deteriorating polyneuropathy, clonal expansion of plasma cells up to 50% of hematopoietic cells and demonstration of the typical t(11;14) translocation (Ig heavy chain locus rearrangement). Subsequently, 4 cycles of induction chemotherapy with velcade, cyclophosphamide and dexamethasone, were administered. At the time of writing, the patient remained alive in generally good health. To the best of our knowledge, with a survival time of >9 years, this case reports the longest survival time of an IgM MM patient to date, which contradicts previous evidence that suggests IgM MM exhibits an aggressive clinical course.
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Copy and paste a formatted citation
Spandidos Publications style
Greuter T, Browne M, Dommann‑Scherrer C, Binder D, Renner C and Kapp U: IgM multiple myeloma with an extremely rare non‑aggressive presentation: A case report. Oncol Lett 12: 2801-2803, 2016.
APA
Greuter, T., Browne, M., Dommann‑Scherrer, C., Binder, D., Renner, C., & Kapp, U. (2016). IgM multiple myeloma with an extremely rare non‑aggressive presentation: A case report. Oncology Letters, 12, 2801-2803. https://doi.org/10.3892/ol.2016.5034
MLA
Greuter, T., Browne, M., Dommann‑Scherrer, C., Binder, D., Renner, C., Kapp, U."IgM multiple myeloma with an extremely rare non‑aggressive presentation: A case report". Oncology Letters 12.4 (2016): 2801-2803.
Chicago
Greuter, T., Browne, M., Dommann‑Scherrer, C., Binder, D., Renner, C., Kapp, U."IgM multiple myeloma with an extremely rare non‑aggressive presentation: A case report". Oncology Letters 12, no. 4 (2016): 2801-2803. https://doi.org/10.3892/ol.2016.5034
Copy and paste a formatted citation
x
Spandidos Publications style
Greuter T, Browne M, Dommann‑Scherrer C, Binder D, Renner C and Kapp U: IgM multiple myeloma with an extremely rare non‑aggressive presentation: A case report. Oncol Lett 12: 2801-2803, 2016.
APA
Greuter, T., Browne, M., Dommann‑Scherrer, C., Binder, D., Renner, C., & Kapp, U. (2016). IgM multiple myeloma with an extremely rare non‑aggressive presentation: A case report. Oncology Letters, 12, 2801-2803. https://doi.org/10.3892/ol.2016.5034
MLA
Greuter, T., Browne, M., Dommann‑Scherrer, C., Binder, D., Renner, C., Kapp, U."IgM multiple myeloma with an extremely rare non‑aggressive presentation: A case report". Oncology Letters 12.4 (2016): 2801-2803.
Chicago
Greuter, T., Browne, M., Dommann‑Scherrer, C., Binder, D., Renner, C., Kapp, U."IgM multiple myeloma with an extremely rare non‑aggressive presentation: A case report". Oncology Letters 12, no. 4 (2016): 2801-2803. https://doi.org/10.3892/ol.2016.5034
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