LIM and SH3 protein 1 promotes tumor proliferation and metastasis in lung carcinoma

  • Authors:
    • Xueqiong Lin
    • Xianhui Liu
    • Yusen Fang
    • Xuefen Weng
  • View Affiliations

  • Published online on: October 5, 2016     https://doi.org/10.3892/ol.2016.5225
  • Pages: 4756-4760
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Abstract

Lung cancer is the most frequently diagnosed cancer and the leading cause of cancer-related mortality worldwide. In the present study, we focused on LIM and SH3 protein 1 (LASP-1), a key molecule involved in the development of multiple cancers, and attempted to elucidate its effect on the oncogenesis of lung cancer. We determined the expression level of LASP‑1 in lung cancer using reverse transcription‑quantitative polymerase chain reaction and western blot analysis, and also studied the potential function of LASP‑1 in lung cancer cell growth, apoptosis and migration by small interfering RNA transfection. The results revealed that the levels of LASP‑1 mRNA and protein were abnormally high in lung cancer cells. Following RNA interference of LASP‑1, the proliferation and migration ability of the human cancer cell line A549 were significantly decreased. In addition, fluorescence‑activated cell sorting analysis indicated that the apoptotic process in the A549 cell line was induced by the silencing of LASP‑1. Our study is the first to investigate the potential of LASP‑1 in lung cancer, and revealed its significant role in regulating the growth and metastasis of lung cancer cells. The present study suggests that LASP‑1 has potential as a therapeutic target in the treatment of lung cancer in the clinic.
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December-2016
Volume 12 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Lin X, Liu X, Fang Y and Weng X: LIM and SH3 protein 1 promotes tumor proliferation and metastasis in lung carcinoma. Oncol Lett 12: 4756-4760, 2016.
APA
Lin, X., Liu, X., Fang, Y., & Weng, X. (2016). LIM and SH3 protein 1 promotes tumor proliferation and metastasis in lung carcinoma. Oncology Letters, 12, 4756-4760. https://doi.org/10.3892/ol.2016.5225
MLA
Lin, X., Liu, X., Fang, Y., Weng, X."LIM and SH3 protein 1 promotes tumor proliferation and metastasis in lung carcinoma". Oncology Letters 12.6 (2016): 4756-4760.
Chicago
Lin, X., Liu, X., Fang, Y., Weng, X."LIM and SH3 protein 1 promotes tumor proliferation and metastasis in lung carcinoma". Oncology Letters 12, no. 6 (2016): 4756-4760. https://doi.org/10.3892/ol.2016.5225