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PARP-1 may be involved in angiogenesis in epithelial ovarian cancer

  • Authors:
    • Wei Wei
    • Yan Li
    • Shuqing Lv
    • Cancan Zhang
    • Yongjie Tian
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China
    Copyright: © Wei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4561-4567
    |
    Published online on: October 5, 2016
       https://doi.org/10.3892/ol.2016.5226
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Abstract

Poly (ADP-ribose) polymerase 1 (PARP-1) is involved in DNA repair and has been implicated in chemoresistance. The present study investigated whether PARP‑1 promotes angiogenesis in ovarian cancer. PARP‑1 and vascular endothelial growth factor A (VEGF-A) expression and CD34+ microvascular density (MVD) were assessed using immunohistochemistry in 60 human epithelial ovarian cancer specimens. PARP‑1 was stably knocked‑down in SKOV3 cells using a specific small interfering RNA (siRNA); angiogenic capacity was assessed using the human umbilical vein endothelial cell (HUVEC) tubule formation assay; and PARP‑1 and VEGF‑A expression were examined by reverse transcription‑quantitative polymerase chain reaction, western blotting and ELISA. PARP‑1 was found to be expressed in 73.3% (44/60) of the human epithelial ovarian cancer specimens and was significantly associated with VEGF‑A, MVD, tumor size, histological grade and lymphatic metastasis (P<0.05). Compared with cells transfected with a negative control siRNA, knockdown of PARP‑1 significantly suppressed the ability of SKOV3 cell‑conditioned media to promote HUVEC tubule formation on Matrigel in vitro. Knockdown of PARP‑1 in SKOV3 cells also significantly reduced VEGF‑A mRNA and protein expression and secretion. In summary, PARP‑1 is overexpressed and may enhance angiogenesis in epithelial ovarian cancer by upregulating VEGF-A.
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1 

Desai A, Xu J, Aysola K, Qin Y, Okoli C, Hariprasad R, Chinemerem U, Gates C, Reddy A, Danner O, et al: Epithelial ovarian cancer: An overview. World J Transl Med. 3:1–8. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Itamochi H: Targeted therapies in epithelial ovarian cancer: Molecular mechanisms of action. World J Biol Chem. 1:209–220. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Schiavone MB, Bashir S and Herzog TJ: Biologic therapies and personalized medicine in gynecologic malignancies. Obstet Gynecol Clin North Am. 39:131–144. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Ocana A, Pandiella A, Siu LL and Tannock IF: Preclinical development of molecular-targeted agents for cancer. Nat Rev Clin Oncol. 8:200–209. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Rajesh M, Mukhopadhyay P, Godlewski G, Bátkai S, Haskó G, Liaudet L and Pacher P: Poly(ADP-ribose)polymerase inhibition decreases angiogenesis. Biochem Biophys Res Commun. 350:1056–1062. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Langelier MF and Pascal JM: PARP-1 mechanism for coupling DNA damage detection to poly(ADP-ribose) synthesis. Curr Opin Stru Biol. 23:134–143. 2013. View Article : Google Scholar

7 

Horton JK, Stefanick DF and Wilson SH: Involvement of poly(ADP-ribose) polymerase activity in regulating Chk1-dependent apoptptic cell death. DNA Repair (Amst). 4:1111–1120. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Shunkwiler L, Ferris G and Kunos C: Inhibition of poly(ADP-Ribose) polymerase enhances radiochemosensitivity in cancers proficient in DNA double-strand break repair. Int J Mol Sci. 14:3773–3785. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Krietsch J, Caron MC, Gagné JP, Ethier C, Vignard J, Vincent M, Rouleau M, Hendzel MJ, Poirier GG and Masson JY: PARP activation regulates the RNA-binding protein NONO in the DNA damage response to DNA double-strand breaks. Nucleic Acids Res. 40:10287–10301. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Zhang J, Kan Y, Tian Y, Wang Z and Zhang J: Effects of poly (ADP-ribosyl) polymerase (PARP) inhibitor on cisplatin resistance & proliferation of the ovarian cancer C13* cells. Indian J Med Res. 137:527–532. 2013.PubMed/NCBI

11 

Pyriochou A, Olah G, Deitch EA, Szabó C and Papapetropoulos A: Inhibition of angiogenesis by the poly(ADP-ribose) polymerase inhibitor PJ-34. Int J Mol Med. 22:113–118. 2008.PubMed/NCBI

12 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Gonçalves A, Sabatier R, Charafe-Jauffret E, Gilabert M, Provansal M, Tarpin C, Extra JM, Viens P and Bertucci F: Triple-negative breast cancer: Histoclinical and molecular features, therapeutic management and perspectives. Bull Cancer. 100:453–464. 2013.(In French). PubMed/NCBI

14 

Salemi M, Galia A, Fraggetta F, La Corte C, Pepe P, La Vignera S, Improta G, Bosco P and Calogero AE: Poly (ADP-ribose) polymerases 1 protein expression in normal and neoplastic prostatic tissue. Eur J Histochem. 57:e132013. View Article : Google Scholar : PubMed/NCBI

15 

Porcelli L, Quatrale AE, Mantuano P, Leo MG, Silvestris N, Rolland JF, Carioggia E, Lioce M, Paradiso A and Azzariti A: Optimize radiochemotherapy in pancreatic cancer: PARP inhibitors a new therapeutic opportunity. Mol Oncol. 7:308–322. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Kim J, Pyun JA, Cho SW, Lee K and Kwack K: Lymph node metastasis of gastric cancer is associated with the interaction between poly (ADP-ribose) polymerase 1 and matrix metallopeptidase 2. DNA Cell Biol. 30:1011–1017. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Rojo F, García-Parra J, Zazo S, Tusquets I, Ferrer-Lozano J, Menendez S, Eroles P, Chamizo C, Servitja S, Ramírez-Merino N, et al: Nuclear PARP-1 protein overexpression is associated with poor overall survival in early breast cancer. Ann Oncol. 23:1156–1164. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Ledermann J, Harter P, Gourley C, Friedlander M, Vergote I, Rustin G, Scott CL, Meier W, Shapira-Frommer R, Safra T, et al: Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer: A preplanned retrospective analysis of outcomes by BRCA status in a randomised phase 2 trial. Lancet Oncol. 15:852–861. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Choi JY, Jang KT, Shim YM, Kim K, Ahn G, Lee KH, Choi Y, Choe YS and Kim BT: Prognostic significance of vascular endothelial growth factor expression and microvessel density in esophageal squamous cell carcinoma: Comparison with positron emission tomography. Ann Surg Oncol. 13:1054–1062. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Rau KM, Huang CC, Chiu TJ, Chen YY, Lu CC, Liu CT, Pei SN and Wei YC: Neovascularization evaluated by CD105 correlates well with prognostic factors in breast cancers. Exp Ther Med. 4:231–236. 2012.PubMed/NCBI

21 

Wang L, Liu X, Wang H and Wang S: Correlation of the expression of vascular endothelial growth factor and its receptors with microvessel density in ovarian cancer. Oncol Lett. 6:175–180. 2013.PubMed/NCBI

22 

Li Q, Li M, Wang YL, Fauzee NJ, Yang Y, Pan J, Yang L and Lazar A: RNA interference of PARG could inhibit the metastatic potency of colon carcinoma cells via PI3-kinase/Akt pathway. Cell Physiol Biochem. 29:361–372. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Quiles-Perez R, Muñoz-Gámez JA, Ruiz-Extremera A, O'Valle F, Sanjuán-Nuñez L, Martín-Alvarez AB, Martín-Oliva D, Caballero T, Muñoz de Rueda P, León J, et al: Inhibition of poly adenosine diphosphate-ribose polymerase decreases hepatocellular carcinoma growth by modulation of tumor-related gene expression. Hepatology. 51:255–266. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Claesson-Welsh L and Welsh M: VEGFA and tumor angiogenesis. J Intern Med. 273:114–127. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wei W, Li Y, Lv S, Zhang C and Tian Y: PARP-1 may be involved in angiogenesis in epithelial ovarian cancer. Oncol Lett 12: 4561-4567, 2016.
APA
Wei, W., Li, Y., Lv, S., Zhang, C., & Tian, Y. (2016). PARP-1 may be involved in angiogenesis in epithelial ovarian cancer. Oncology Letters, 12, 4561-4567. https://doi.org/10.3892/ol.2016.5226
MLA
Wei, W., Li, Y., Lv, S., Zhang, C., Tian, Y."PARP-1 may be involved in angiogenesis in epithelial ovarian cancer". Oncology Letters 12.6 (2016): 4561-4567.
Chicago
Wei, W., Li, Y., Lv, S., Zhang, C., Tian, Y."PARP-1 may be involved in angiogenesis in epithelial ovarian cancer". Oncology Letters 12, no. 6 (2016): 4561-4567. https://doi.org/10.3892/ol.2016.5226
Copy and paste a formatted citation
x
Spandidos Publications style
Wei W, Li Y, Lv S, Zhang C and Tian Y: PARP-1 may be involved in angiogenesis in epithelial ovarian cancer. Oncol Lett 12: 4561-4567, 2016.
APA
Wei, W., Li, Y., Lv, S., Zhang, C., & Tian, Y. (2016). PARP-1 may be involved in angiogenesis in epithelial ovarian cancer. Oncology Letters, 12, 4561-4567. https://doi.org/10.3892/ol.2016.5226
MLA
Wei, W., Li, Y., Lv, S., Zhang, C., Tian, Y."PARP-1 may be involved in angiogenesis in epithelial ovarian cancer". Oncology Letters 12.6 (2016): 4561-4567.
Chicago
Wei, W., Li, Y., Lv, S., Zhang, C., Tian, Y."PARP-1 may be involved in angiogenesis in epithelial ovarian cancer". Oncology Letters 12, no. 6 (2016): 4561-4567. https://doi.org/10.3892/ol.2016.5226
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