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Article

Interleukin-6 promotes tumor progression in colitis‑associated colorectal cancer through HIF-1α regulation

  • Authors:
    • Jun Han
    • Qiulei Xi
    • Qingyang Meng
    • Jingzheng Liu
    • Yongxian Zhang
    • Yusong Han
    • Qiulin Zhuang
    • Yi Jiang
    • Qiurong Ding
    • Guohao Wu
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China, Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, P.R. China
  • Pages: 4665-4670
    |
    Published online on: October 5, 2016
       https://doi.org/10.3892/ol.2016.5227
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Abstract

Interleukin-6 (IL-6) is a well-known etiological factor of colitis‑associated colorectal cancer (CAC) and has a significant role in CAC progression. In addition, hypoxia‑inducible factor 1α (HIF‑1α) serves a primary role in the progression of CAC. However, the association between IL‑6 and HIF‑1α during the progression of CAC remains unclear. To investigate this association, the present study induced CAC in a mouse model using azoxymethane and dextran sulfate sodium. In addition, an anti‑IL‑6 receptor antibody was used to inhibit IL‑6. In this model, anti‑IL‑6 receptor antibody treatment significantly inhibited the development of CAC and the expression of HIF‑1α, in colorectal adenomas and adenocarcinomas. In patients with CAC, the HIF‑1α gene was demonstrated to be overexpressed in tumor tissue compared with adjacent non‑malignant tissue. Furthermore, HIF‑1α mRNA expression was positively correlated with serum IL‑6 concentration. The results of the present study suggest that IL‑6 promotes CAC progression, in the early stage of the disease, through HIF-1α regulation.
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1 

Grivennikov SI: Inflammation and colorectal cancer: Colitis-associated neoplasia. Semin Immunopathol. 35:229–244. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Lakatos PL and Lakatos L: Risk for colorectal cancer in ulcerative colitis: Changes, causes and management strategies. World J Gastroenterol. 14:3937–3947. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Ullman TA and Itzkowitz SH: Intestinal inflammation and cancer. Gastroenterology. 140:1807–1816. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Waldner MJ and Neurath MF: Cytokines in colitis associated cancer: Potential drug targets? Inflamm Allergy Drug Targets. 7:187–194. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Dubois RN: Role of inflammation and inflammatory mediators in colorectal cancer. Trans Am Clin Climatol Assoc. 125:358–373. 2014.PubMed/NCBI

6 

Li Y, Deuring J, Peppelenbosch MP, Kuipers EJ, de Haar C and van der Woude CJ: IL-6-induced DNMT1 activity mediates SOCS3 promoter hypermethylation in ulcerative colitis-related colorectal cancer. Carcinogenesis. 33:1889–1896. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Qi H, Yang H, Xu G, Ren J, Hua W, Shi Y, Torsvik M, Florholmen J and Cui G: Therapeutic efficacy of IL-17A antibody injection in preventing the development of colitis associated carcinogenesis in mice. Immunobiology. 220:54–59. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Waldner MJ, Foersch S and Neurath MF: Interleukin-6-a key regulator of colorectal cancer development. Int J Biol Sci. 8:1248–1253. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Li Y, de Haar C, Chen M, Deuring J, Gerrits MM, Smits R, Xia B, Kuipers EJ and van der Woude CJ: Disease-related expression of the IL6/STAT3/SOCS3 signalling pathway in ulcerative colitis and ulcerative colitis-related carcinogenesis. Gut. 59:227–235. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Monti E and Gariboldi MB: HIF-1 as a target for cancer chemotherapy, chemosensitization and chemoprevention. Curr Mol Pharmacol. 4:62–77. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Wang GL, Jiang BH, Rue EA and Semenza GL: Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA. 92:5510–5514. 1995. View Article : Google Scholar : PubMed/NCBI

12 

Feldser D, Agani F, Iyer NV, Pak B, Ferreira G and Semenza GL: Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2. Cancer Res. 59:3915–3918. 1999.PubMed/NCBI

13 

Laughner E, Taghavi P, Chiles K, Mahon PC and Semenza GL: HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol Cell Biol. 21:3995–4004. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Hellwig-Bürgel T, Rutkowski K, Metzen E, Fandrey J and Jelkmann W: Interleukin-1beta and tumor necrosis factor-alpha stimulate DNA binding of hypoxia-inducible factor-1. Blood. 94:1561–1567. 1999.PubMed/NCBI

15 

Chen C, Pore N, Behrooz A, Ismail-Beigi F and Maity A: Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia. J Biol Chem. 276:9519–9525. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Zundel W, Schindler C, Haas-Kogan D, Koong A, Kaper F, Chen E, Gottschalk AR, Ryan HE, Johnson RS, Jefferson AB, et al: Loss of PTEN facilitates HIF-1-mediated gene expression. Genes Dev. 14:391–396. 2000.PubMed/NCBI

17 

Liao D and Johnson RS: Hypoxia: A key regulator of angiogenesis in cancer. Cancer Metastasis Rev. 26:281–290. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Semenza GL: Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene. 29:625–634. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Pugh CW and Ratcliffe PJ: Regulation of angiogenesis by hypoxia: Role of the HIF system. Nat Med. 9:677–684. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Krishnamachary B, Berg-Dixon S, Kelly B, Agani F, Feldser D, Ferreira G, Iyer N, LaRusch J, Pak B, Taghavi P and Semenza GL: Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1. Cancer Res. 63:1138–1143. 2003.PubMed/NCBI

21 

Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA, Zagzag D, Buechler P, Isaacs WB, Semenza GL and Simons JW: Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res. 59:5830–5835. 1999.PubMed/NCBI

22 

Mariani F, Sena P, Marzona L, Riccio M, Fano R, Manni P, Gregorio CD, Pezzi A, Leon MP, Monni S, et al: Cyclooxygenase-2 and Hypoxia-Inducible Factor-1alpha protein expression is related to inflammation, and up-regulated since the early steps of colorectal carcinogenesis. Cancer Lett. 279:221–229. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Fransén K, Fenech M, Fredrikson M, Dabrosin C and Söderkvist P: Association between ulcerative growth and hypoxia inducible factor-1alpha polymorphisms in colorectal cancer patients. Mol Carcinog. 45:833–840. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Neufert C, Becker C and Neurath MF: An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammation-driven tumor progression. Nat Protoc. 2:1998–2004. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Yuan L, Han J, Meng Q, Xi Q, Zhuang Q, Jiang Y, Han Y, Zhang B, Fang J and Wu G: Muscle-specific E3 ubiquitin ligases are involved in muscle atrophy of cancer cachexia: An in vitro and in vivo study. Oncol Rep. 33:2261–2268. 2015.PubMed/NCBI

26 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Grivennikov SI and Karin M: Inflammation and oncogenesis: A vicious connection. Curr Opin Genet Dev. 20:65–71. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Suzuki R, Kohno H, Sugie S, Nakagama H and Tanaka T: Strain differences in the susceptibility to azoxymethane and dextran sodium sulfate-induced colon carcinogenesis in mice. Carcinogenesis. 27:162–169. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Becker C, Fantini MC, Schramm C, Lehr HA, Wirtz S, Nikolaev A, Burg J, Strand S, Kiesslich R, Huber S, et al: TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling. Immunity. 21:491–501. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Middleton K, Jones J, Lwin Z and Coward JI: Interleukin-6: An angiogenic target in solid tumours. Crit Rev Oncol Hematol. 89:129–139. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Bataille R, Barlogie B, Lu ZY, Rossi JF, Lavabre-Bertrand T, Beck T, Wijdenes J, Brochier J and Klein B: Biologic effects of anti-interleukin-6 murine monoclonal antibody in advanced multiple myeloma. Blood. 86:685–691. 1995.PubMed/NCBI

32 

Racadot E, Audhuy B, Duvernoy H, Thyss A, Lang JM, Wijdenes J and Hervé P: Clinical and immunological follow-up of patients with AIDS-associated Kaposi's sarcoma treated with an anti-IL-6 monoclonal antibody. Cytokines Mol Ther. 1:133–138. 1995.PubMed/NCBI

33 

van Rhee F, Wong RS, Munshi N, Rossi JF, Ke XY, Fosså A, Simpson D, Capra M, Liu T, Hsieh RK, et al: Siltuximab for multicentric Castleman's disease: A randomised, double-blind, placebo-controlled trial. Lancet Oncol. 15:966–974. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Rossi JF, Négrier S, James ND, Kocak I, Hawkins R, Davis H, Prabhakar U, Qin X, Mulders P and Berns B: A phase I/II study of siltuximab (CNTO 328), an anti-interleukin-6 monoclonal antibody, in metastatic renal cell cancer. Br J Cancer. 103:1154–1162. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Fizazi K, De Bono JS, Flechon A, Heidenreich A, Voog E, Davis NB, Qi M, Bandekar R, Vermeulen JT, Cornfeld M and Hudes GR: Randomised phase II study of siltuximab (CNTO 328), an anti-IL-6 monoclonal antibody, in combination with mitoxantrone/prednisone versus mitoxantrone/prednisone alone in metastatic castration-resistant prostate cancer. Eur J Cancer. 48:85–93. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Angevin E, Tabernero J, Elez E, Cohen SJ, Bahleda R, van Laethem JL, Ottensmeier C, Lopez-Martin JA, Clive S, Joly F, et al: A phase I/II, multiple-dose, dose-escalation study of siltuximab, an anti-interleukin-6 monoclonal antibody, in patients with advanced solid tumors. Clin Cancer Res. 20:2192–2204. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Tanaka T, Narazaki M and Kishimoto T: Therapeutic targeting of the interleukin-6 receptor. Annu Rev Pharmacol Toxicol. 52:199–219. 2012. View Article : Google Scholar : PubMed/NCBI

38 

Grivennikov S, Karin E, Terzic J, Mucida D, Yu GY, Vallabhapurapu S, Scheller J, Rose-John S, Cheroutre H, Eckmann L and Karin M: IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell. 15:103–113. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Bollrath J, Phesse TJ, von Burstin VA, Putoczki T, Bennecke M, Bateman T, Nebelsiek T, Lundgren-May T, Canli O, Schwitalla S, et al: gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis. Cancer Cell. 15:91–102. 2009. View Article : Google Scholar : PubMed/NCBI

40 

Rigby RJ, Simmons JG, Greenhalgh CJ, Alexander WS and Lund PK: Suppressor of cytokine signaling 3 (SOCS3) limits damage-induced crypt hyper-proliferation and inflammation-associated tumorigenesis in the colon. Oncogene. 26:4833–4841. 2007. View Article : Google Scholar : PubMed/NCBI

41 

Waldner MJ, Wirtz S, Jefremow A, Warntjen M, Neufert C, Atreya R, Becker C, Weigmann B, Vieth M, Rose-John S and Neurath MF: VEGF receptor signaling links inflammation and tumorigenesis in colitis-associated cancer. J Exp Med. 207:2855–2868. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Han J, Xi Q, Meng Q, Liu J, Zhang Y, Han Y, Zhuang Q, Jiang Y, Ding Q, Wu G, Wu G, et al: Interleukin-6 promotes tumor progression in colitis‑associated colorectal cancer through HIF-1α regulation. Oncol Lett 12: 4665-4670, 2016.
APA
Han, J., Xi, Q., Meng, Q., Liu, J., Zhang, Y., Han, Y. ... Wu, G. (2016). Interleukin-6 promotes tumor progression in colitis‑associated colorectal cancer through HIF-1α regulation. Oncology Letters, 12, 4665-4670. https://doi.org/10.3892/ol.2016.5227
MLA
Han, J., Xi, Q., Meng, Q., Liu, J., Zhang, Y., Han, Y., Zhuang, Q., Jiang, Y., Ding, Q., Wu, G."Interleukin-6 promotes tumor progression in colitis‑associated colorectal cancer through HIF-1α regulation". Oncology Letters 12.6 (2016): 4665-4670.
Chicago
Han, J., Xi, Q., Meng, Q., Liu, J., Zhang, Y., Han, Y., Zhuang, Q., Jiang, Y., Ding, Q., Wu, G."Interleukin-6 promotes tumor progression in colitis‑associated colorectal cancer through HIF-1α regulation". Oncology Letters 12, no. 6 (2016): 4665-4670. https://doi.org/10.3892/ol.2016.5227
Copy and paste a formatted citation
x
Spandidos Publications style
Han J, Xi Q, Meng Q, Liu J, Zhang Y, Han Y, Zhuang Q, Jiang Y, Ding Q, Wu G, Wu G, et al: Interleukin-6 promotes tumor progression in colitis‑associated colorectal cancer through HIF-1α regulation. Oncol Lett 12: 4665-4670, 2016.
APA
Han, J., Xi, Q., Meng, Q., Liu, J., Zhang, Y., Han, Y. ... Wu, G. (2016). Interleukin-6 promotes tumor progression in colitis‑associated colorectal cancer through HIF-1α regulation. Oncology Letters, 12, 4665-4670. https://doi.org/10.3892/ol.2016.5227
MLA
Han, J., Xi, Q., Meng, Q., Liu, J., Zhang, Y., Han, Y., Zhuang, Q., Jiang, Y., Ding, Q., Wu, G."Interleukin-6 promotes tumor progression in colitis‑associated colorectal cancer through HIF-1α regulation". Oncology Letters 12.6 (2016): 4665-4670.
Chicago
Han, J., Xi, Q., Meng, Q., Liu, J., Zhang, Y., Han, Y., Zhuang, Q., Jiang, Y., Ding, Q., Wu, G."Interleukin-6 promotes tumor progression in colitis‑associated colorectal cancer through HIF-1α regulation". Oncology Letters 12, no. 6 (2016): 4665-4670. https://doi.org/10.3892/ol.2016.5227
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