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Article

Upregulated miR-193a-3p as an oncogene in esophageal squamous cell carcinoma regulating cellular proliferation, migration and apoptosis

  • Authors:
    • Yunfeng Yi
    • Jianming Chen
    • Changjie Jiao
    • Jing Zhong
    • Zhiming Song
    • Xiaoping Yu
    • Xiujuan Lu
    • Baoli Lin
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, Dongnan Affiliated Hospital of Xiamen University, Zhangzhou, Fujian 363000, P.R. China
  • Pages: 4779-4784
    |
    Published online on: October 5, 2016
       https://doi.org/10.3892/ol.2016.5229
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Abstract

MicroRNAs (miRs) are small endogenous non‑coding RNAs that play a vital role in carcinogenesis. miR‑193a‑3p has been described in multiple cancers. However, the function of miR‑193a‑3p in esophageal squamous cell carcinoma (ESCC) is still unclear. To explore the role of miR‑193a‑3p in ESCC, reverse transcription‑quantitative polymerase chain reaction was used to evaluate the expression of miR‑193a‑3p in 48 paired ESCC and adjacent normal tissues. In addition, the impact of miR-193a-3p on cell proliferation, migration and apoptosis were analyzed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, wound scratch assay and flow cytometry, respectively. The results revealed that miR‑193a‑3p was upregulated in ESCC, compared with adjacent normal tissues. Downregulation of miR‑193a‑3p expression using a synthesized inhibitor suppressed cell proliferation and migration, and induced cell apoptosis, indicating that miR‑193a‑3p could be characterized as an oncogene in ESCC. In summary, the present study demonstrated that miR‑193a‑3p was upregulated in ESCC, where it plays a significant role by affecting cellular proliferation, migration and apoptosis.
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Copy and paste a formatted citation
Spandidos Publications style
Yi Y, Chen J, Jiao C, Zhong J, Song Z, Yu X, Lu X and Lin B: Upregulated miR-193a-3p as an oncogene in esophageal squamous cell carcinoma regulating cellular proliferation, migration and apoptosis. Oncol Lett 12: 4779-4784, 2016.
APA
Yi, Y., Chen, J., Jiao, C., Zhong, J., Song, Z., Yu, X. ... Lin, B. (2016). Upregulated miR-193a-3p as an oncogene in esophageal squamous cell carcinoma regulating cellular proliferation, migration and apoptosis. Oncology Letters, 12, 4779-4784. https://doi.org/10.3892/ol.2016.5229
MLA
Yi, Y., Chen, J., Jiao, C., Zhong, J., Song, Z., Yu, X., Lu, X., Lin, B."Upregulated miR-193a-3p as an oncogene in esophageal squamous cell carcinoma regulating cellular proliferation, migration and apoptosis". Oncology Letters 12.6 (2016): 4779-4784.
Chicago
Yi, Y., Chen, J., Jiao, C., Zhong, J., Song, Z., Yu, X., Lu, X., Lin, B."Upregulated miR-193a-3p as an oncogene in esophageal squamous cell carcinoma regulating cellular proliferation, migration and apoptosis". Oncology Letters 12, no. 6 (2016): 4779-4784. https://doi.org/10.3892/ol.2016.5229
Copy and paste a formatted citation
x
Spandidos Publications style
Yi Y, Chen J, Jiao C, Zhong J, Song Z, Yu X, Lu X and Lin B: Upregulated miR-193a-3p as an oncogene in esophageal squamous cell carcinoma regulating cellular proliferation, migration and apoptosis. Oncol Lett 12: 4779-4784, 2016.
APA
Yi, Y., Chen, J., Jiao, C., Zhong, J., Song, Z., Yu, X. ... Lin, B. (2016). Upregulated miR-193a-3p as an oncogene in esophageal squamous cell carcinoma regulating cellular proliferation, migration and apoptosis. Oncology Letters, 12, 4779-4784. https://doi.org/10.3892/ol.2016.5229
MLA
Yi, Y., Chen, J., Jiao, C., Zhong, J., Song, Z., Yu, X., Lu, X., Lin, B."Upregulated miR-193a-3p as an oncogene in esophageal squamous cell carcinoma regulating cellular proliferation, migration and apoptosis". Oncology Letters 12.6 (2016): 4779-4784.
Chicago
Yi, Y., Chen, J., Jiao, C., Zhong, J., Song, Z., Yu, X., Lu, X., Lin, B."Upregulated miR-193a-3p as an oncogene in esophageal squamous cell carcinoma regulating cellular proliferation, migration and apoptosis". Oncology Letters 12, no. 6 (2016): 4779-4784. https://doi.org/10.3892/ol.2016.5229
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