HER2 gene amplification in patients with prostate cancer: Evaluating a CISH-based method

  • Authors:
    • Nazanin Sharifi
    • Arash Salmaninejad
    • Samira Ferdosi
    • Abolfazl Nesaei Bajestani
    • Malihe Khaleghiyan
    • Mehrdad Asghari Estiar
    • Mansour Jamali
    • Mohammad Reza Nowroozi
    • Abbas Shakoori
  • View Affiliations

  • Published online on: October 10, 2016     https://doi.org/10.3892/ol.2016.5235
  • Pages: 4651-4658
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Abstract

Prostate cancer (PCa) is one of the most widespread malignancies in the world. The role of the human epidermal growth factor receptor 2 (HER2) in the pathogenesis and progression of human PCa remains poorly understood. In contradiction with breast cancer, studies on HER2 overexpression and gene amplification in PCa have produced varying results, although the HER2 oncogene has been implicated in the biology of numerous tumor types, and serves as a prognostic marker and therapeutic target in breast cancer. Technical challenges are considered the main reasons for data discrepancies. Amplification of the HER2 gene has previously been reported in PCa, in which it was associated with tumor progression. The present study aimed to evaluate the prevalence and clinical significance of HER2 amplification in PCa. A total of 32 biopsy samples obtained from human prostate adenocarcinomas were evaluated by chromogenic in situ hybridization (CISH) to determine the frequency of patients with HER2 gene amplifications. High copy numbers of HER2 were detected in 19 of the prostate tumors analyzed. The results of the present study suggested that, in patients without amplification of HER2, high levels of prostate‑specific antigen or a high Gleason score were not significantly correlated with a high pathologic stage. Furthermore, amplification levels of the HER2 gene were directly associated with pathologic stage in patients with PCa. Therefore, the potential use of HER2 as a prognostic factor or therapeutic target for PCa warrants further study.
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December-2016
Volume 12 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Sharifi N, Salmaninejad A, Ferdosi S, Bajestani AN, Khaleghiyan M, Estiar MA, Jamali M, Nowroozi MR and Shakoori A: HER2 gene amplification in patients with prostate cancer: Evaluating a CISH-based method. Oncol Lett 12: 4651-4658, 2016
APA
Sharifi, N., Salmaninejad, A., Ferdosi, S., Bajestani, A.N., Khaleghiyan, M., Estiar, M.A. ... Shakoori, A. (2016). HER2 gene amplification in patients with prostate cancer: Evaluating a CISH-based method. Oncology Letters, 12, 4651-4658. https://doi.org/10.3892/ol.2016.5235
MLA
Sharifi, N., Salmaninejad, A., Ferdosi, S., Bajestani, A. N., Khaleghiyan, M., Estiar, M. A., Jamali, M., Nowroozi, M. R., Shakoori, A."HER2 gene amplification in patients with prostate cancer: Evaluating a CISH-based method". Oncology Letters 12.6 (2016): 4651-4658.
Chicago
Sharifi, N., Salmaninejad, A., Ferdosi, S., Bajestani, A. N., Khaleghiyan, M., Estiar, M. A., Jamali, M., Nowroozi, M. R., Shakoori, A."HER2 gene amplification in patients with prostate cancer: Evaluating a CISH-based method". Oncology Letters 12, no. 6 (2016): 4651-4658. https://doi.org/10.3892/ol.2016.5235