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Article Open Access

UBE2T silencing suppresses proliferation and induces cell cycle arrest and apoptosis in bladder cancer cells

Corrigendum in: /10.3892/ol.2025.15326
  • Authors:
    • Yan Qing Gong
    • Ding Peng
    • Xiang Hui Ning
    • Xin Yu Yang
    • Xue Song Li
    • Li Qun Zhou
    • Ying Lu Guo
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Peking University First Hospital, Beijing 100034, P.R. China
    Copyright: © Gong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4485-4492
    |
    Published online on: October 10, 2016
       https://doi.org/10.3892/ol.2016.5237
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Abstract

Ubiquitin-conjugating enzyme E2T (UBE2T), a member of the ubiquitin-conjugating E2 family in the ubiquitin-proteasome pathway, has been reported to be overexpressed in certain tumor types and to have an important role in the Fanconi anemia pathway. In the present study, the expression of UBE2T and its association with bladder cancer were investigated; to the best of our knowledge, this has not been reported previously. Immunohistochemistry and western blot analysis demonstrated that UBE2T was significantly upregulated in bladder cancer tissues and cell lines compared with adjacent normal bladder tissues and a normal human urinary tract epithelial cell line, respectively. UBE2T was detectable in the nuclei and cytoplasm of cancer cells, exhibiting stronger expression in the nuclei. A UBE2T‑siRNA‑expressing lentivirus was constructed and used to infect human bladder cancer 5637 cells, in order to examine the role of UBE2T in bladder cancer cell growth in vitro. The knockdown of UBE2T significantly decreased bladder cancer cell proliferation and colony formation. Furthermore, UBE2T silencing induced cell cycle arrest at G2/M phase and increased cell apoptosis. Therefore, UBE2T serves an important role in the growth of bladder cancer cells, and may be considered as a potential biomarker and therapeutic target for bladder cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Gong YQ, Peng D, Ning XH, Yang XY, Li XS, Zhou LQ and Guo YL: UBE2T silencing suppresses proliferation and induces cell cycle arrest and apoptosis in bladder cancer cells Corrigendum in /10.3892/ol.2025.15326. Oncol Lett 12: 4485-4492, 2016.
APA
Gong, Y.Q., Peng, D., Ning, X.H., Yang, X.Y., Li, X.S., Zhou, L.Q., & Guo, Y.L. (2016). UBE2T silencing suppresses proliferation and induces cell cycle arrest and apoptosis in bladder cancer cells Corrigendum in /10.3892/ol.2025.15326. Oncology Letters, 12, 4485-4492. https://doi.org/10.3892/ol.2016.5237
MLA
Gong, Y. Q., Peng, D., Ning, X. H., Yang, X. Y., Li, X. S., Zhou, L. Q., Guo, Y. L."UBE2T silencing suppresses proliferation and induces cell cycle arrest and apoptosis in bladder cancer cells Corrigendum in /10.3892/ol.2025.15326". Oncology Letters 12.6 (2016): 4485-4492.
Chicago
Gong, Y. Q., Peng, D., Ning, X. H., Yang, X. Y., Li, X. S., Zhou, L. Q., Guo, Y. L."UBE2T silencing suppresses proliferation and induces cell cycle arrest and apoptosis in bladder cancer cells Corrigendum in /10.3892/ol.2025.15326". Oncology Letters 12, no. 6 (2016): 4485-4492. https://doi.org/10.3892/ol.2016.5237
Copy and paste a formatted citation
x
Spandidos Publications style
Gong YQ, Peng D, Ning XH, Yang XY, Li XS, Zhou LQ and Guo YL: UBE2T silencing suppresses proliferation and induces cell cycle arrest and apoptosis in bladder cancer cells Corrigendum in /10.3892/ol.2025.15326. Oncol Lett 12: 4485-4492, 2016.
APA
Gong, Y.Q., Peng, D., Ning, X.H., Yang, X.Y., Li, X.S., Zhou, L.Q., & Guo, Y.L. (2016). UBE2T silencing suppresses proliferation and induces cell cycle arrest and apoptosis in bladder cancer cells Corrigendum in /10.3892/ol.2025.15326. Oncology Letters, 12, 4485-4492. https://doi.org/10.3892/ol.2016.5237
MLA
Gong, Y. Q., Peng, D., Ning, X. H., Yang, X. Y., Li, X. S., Zhou, L. Q., Guo, Y. L."UBE2T silencing suppresses proliferation and induces cell cycle arrest and apoptosis in bladder cancer cells Corrigendum in /10.3892/ol.2025.15326". Oncology Letters 12.6 (2016): 4485-4492.
Chicago
Gong, Y. Q., Peng, D., Ning, X. H., Yang, X. Y., Li, X. S., Zhou, L. Q., Guo, Y. L."UBE2T silencing suppresses proliferation and induces cell cycle arrest and apoptosis in bladder cancer cells Corrigendum in /10.3892/ol.2025.15326". Oncology Letters 12, no. 6 (2016): 4485-4492. https://doi.org/10.3892/ol.2016.5237
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