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Article Open Access

miR-217 regulates tumor growth and apoptosis by targeting the MAPK signaling pathway in colorectal cancer

  • Authors:
    • Nan Zhang
    • Canrong Lu
    • Lin Chen
  • View Affiliations / Copyright

    Affiliations: General Surgery Center Department of Chinese PLA General Hospital, Beijing 100853, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4589-4597
    |
    Published online on: October 13, 2016
       https://doi.org/10.3892/ol.2016.5249
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Abstract

MicroRNA (miR)-217 has been reported to participate in carcinogenesis and tumor progression in several cancers; however, its expression and biological functions in colorectal cancer (CRC) are still unclear. The present study demonstrated that miR-217 expression was significantly higher in matched adjacent noncancerous tissues than in CRC tissues (P<0.001). In addition, it was observed that low‑grade CRC exhibited greater expression of miR‑217 compared with high‑grade CRC (P<0.05). Kaplan‑Meier survival and Cox regression analyses revealed that overall survival rates were significantly poorer in the low‑expression group relative to the high‑expression group (P<0.005). Next, a potential miR‑217 target, mitogen‑activated protein kinase (MAPK) 1, was identified. Upregulation of miR‑217 could significantly downregulate MAPK1 expression. CRC cells overexpressing miR‑217 exhibited cell growth inhibition by significant enhancement of apoptosis in vitro. The present study further investigated the MAPK signaling pathway to verify the mechanisms, and revealed that KRAS and Raf‑1 expression was downregulated in miR‑217‑overexpressing RKO cells. Taken together, our results revealed that miR‑217 inhibits tumor growth and enhances apoptosis in CRC, and that this is associated with the downregulation of MAPK signaling. These results indicate that miR‑217 is a promising therapeutic target for the treatment of CRC.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang N, Lu C and Chen L: miR-217 regulates tumor growth and apoptosis by targeting the MAPK signaling pathway in colorectal cancer. Oncol Lett 12: 4589-4597, 2016.
APA
Zhang, N., Lu, C., & Chen, L. (2016). miR-217 regulates tumor growth and apoptosis by targeting the MAPK signaling pathway in colorectal cancer. Oncology Letters, 12, 4589-4597. https://doi.org/10.3892/ol.2016.5249
MLA
Zhang, N., Lu, C., Chen, L."miR-217 regulates tumor growth and apoptosis by targeting the MAPK signaling pathway in colorectal cancer". Oncology Letters 12.6 (2016): 4589-4597.
Chicago
Zhang, N., Lu, C., Chen, L."miR-217 regulates tumor growth and apoptosis by targeting the MAPK signaling pathway in colorectal cancer". Oncology Letters 12, no. 6 (2016): 4589-4597. https://doi.org/10.3892/ol.2016.5249
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang N, Lu C and Chen L: miR-217 regulates tumor growth and apoptosis by targeting the MAPK signaling pathway in colorectal cancer. Oncol Lett 12: 4589-4597, 2016.
APA
Zhang, N., Lu, C., & Chen, L. (2016). miR-217 regulates tumor growth and apoptosis by targeting the MAPK signaling pathway in colorectal cancer. Oncology Letters, 12, 4589-4597. https://doi.org/10.3892/ol.2016.5249
MLA
Zhang, N., Lu, C., Chen, L."miR-217 regulates tumor growth and apoptosis by targeting the MAPK signaling pathway in colorectal cancer". Oncology Letters 12.6 (2016): 4589-4597.
Chicago
Zhang, N., Lu, C., Chen, L."miR-217 regulates tumor growth and apoptosis by targeting the MAPK signaling pathway in colorectal cancer". Oncology Letters 12, no. 6 (2016): 4589-4597. https://doi.org/10.3892/ol.2016.5249
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