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Article Open Access

t(14;18)(q32;q21) in chronic lymphocytic leukemia patients: Report of two cases and a literature review

  • Authors:
    • Weifeng Chen
    • Yi Miao
    • Rong Wang
    • Yujie Wu
    • Hairong Qiu
    • Wei Xu
    • Jianyong Li
    • Lei Fan
    • Xin Xu
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, The Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin, Jiangsu 214400, P.R. China, Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, Jiangsu 210029, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4351-4356
    |
    Published online on: October 13, 2016
       https://doi.org/10.3892/ol.2016.5258
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Abstract

The chromosomal abnormality t(14;18)(q32;q21) is most commonly associated with germinal center‑derived B‑cell lymphomas, particularly follicular lymphoma (FL). Generally, it is considered a hallmark of FL. The t(14;18)(q32;q21) translocation is rare in chronic lymphocytic leukemia (CLL) and its prognostic significance remains unclear. In the present study, two cases of CLL with t(14;18)(q32;q21) were diagnosed using conventional cytogenetic analysis and fluorescence in situ hybridization. Both patients presented with leukemia and the morphological features and immunophenotypes were typical of CLL. Case 2 underwent a further lymph node biopsy, which established a diagnosis of CD5‑ CLL/small lymphocyte lymphoma. In addition to t(14;18)(q32;q21), trisomy 12 was identified in the same clone in Case 2. Both cases exhibited immunoglobulin heavy chain variable mutations, and heavy‑chain variable region gene (VH) 4‑39 and VH3‑62 were used in Case 1 and Case 2, respectively. In addition, direct Sanger sequencing of exons 4‑9 revealed that Case 2 harbored the tumor protein p53 mutation, c.829T>G. Both cases had indications for therapy. Case 1 responded well to chlorambucil treatment, and was still alive at the last follow‑up. Conversely, Case 2 exhibited aggressive disease that appeared refractory to treatment, and eventually succumbed to the disease.
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Copy and paste a formatted citation
Spandidos Publications style
Chen W, Miao Y, Wang R, Wu Y, Qiu H, Xu W, Li J, Fan L and Xu X: t(14;18)(q32;q21) in chronic lymphocytic leukemia patients: Report of two cases and a literature review. Oncol Lett 12: 4351-4356, 2016.
APA
Chen, W., Miao, Y., Wang, R., Wu, Y., Qiu, H., Xu, W. ... Xu, X. (2016). t(14;18)(q32;q21) in chronic lymphocytic leukemia patients: Report of two cases and a literature review. Oncology Letters, 12, 4351-4356. https://doi.org/10.3892/ol.2016.5258
MLA
Chen, W., Miao, Y., Wang, R., Wu, Y., Qiu, H., Xu, W., Li, J., Fan, L., Xu, X."t(14;18)(q32;q21) in chronic lymphocytic leukemia patients: Report of two cases and a literature review". Oncology Letters 12.6 (2016): 4351-4356.
Chicago
Chen, W., Miao, Y., Wang, R., Wu, Y., Qiu, H., Xu, W., Li, J., Fan, L., Xu, X."t(14;18)(q32;q21) in chronic lymphocytic leukemia patients: Report of two cases and a literature review". Oncology Letters 12, no. 6 (2016): 4351-4356. https://doi.org/10.3892/ol.2016.5258
Copy and paste a formatted citation
x
Spandidos Publications style
Chen W, Miao Y, Wang R, Wu Y, Qiu H, Xu W, Li J, Fan L and Xu X: t(14;18)(q32;q21) in chronic lymphocytic leukemia patients: Report of two cases and a literature review. Oncol Lett 12: 4351-4356, 2016.
APA
Chen, W., Miao, Y., Wang, R., Wu, Y., Qiu, H., Xu, W. ... Xu, X. (2016). t(14;18)(q32;q21) in chronic lymphocytic leukemia patients: Report of two cases and a literature review. Oncology Letters, 12, 4351-4356. https://doi.org/10.3892/ol.2016.5258
MLA
Chen, W., Miao, Y., Wang, R., Wu, Y., Qiu, H., Xu, W., Li, J., Fan, L., Xu, X."t(14;18)(q32;q21) in chronic lymphocytic leukemia patients: Report of two cases and a literature review". Oncology Letters 12.6 (2016): 4351-4356.
Chicago
Chen, W., Miao, Y., Wang, R., Wu, Y., Qiu, H., Xu, W., Li, J., Fan, L., Xu, X."t(14;18)(q32;q21) in chronic lymphocytic leukemia patients: Report of two cases and a literature review". Oncology Letters 12, no. 6 (2016): 4351-4356. https://doi.org/10.3892/ol.2016.5258
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