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Article Open Access

Overexpression of microRNA-205 predicts lymph node metastasis and indicates an unfavorable prognosis in endometrial cancer

  • Authors:
    • Yong‑Jing Ma
    • Chun‑Fang Ha
    • Zhi‑Miao Bai
    • Hai‑Ning Li
    • Ying Xiong
    • Jie Jiang
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, P.R. China, Department of Gynecology, General Hospital Affiliated to Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China
    Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4403-4410
    |
    Published online on: October 14, 2016
       https://doi.org/10.3892/ol.2016.5262
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Abstract

As an integral component of the surgical staging system, lymphadenectomy for patients with endometrial cancer (EC) remains controversial, particularly in clinical stage I disease that includes not only low-risk, but also high‑risk subgroups. In order to maximize the therapeutic effect of lymph node excision for high‑risk patients who can potentially obtain survival benefits from it while minimizing its reverse effects in low‑risk patients, pre‑operative risk stratification of lymph node metastasis is necessary. The upregulation of microRNA‑205 (miR‑205) in carcinoma of the endometrium has been consistently reported recently and has been found to correlate with poor survival. The current study aimed to investigate whether the overexpression of miR‑205 in curettage samples of EC could identify patients who are at a high risk for lymph node metastasis prior to surgery and validate the role of miR‑205 as a prognostic marker in EC. Relative quantification detection of miR‑205 in curettage and hysterectomy specimens of patients with EC was performed. Prediction of lymph node metastasis based on miR‑205 expression, as well as tumor type and grade in curettage samples, was performed for all EC patients and patients with clinical stage I disease. Moreover, survival analysis was conducted. It was observed that miR‑205 was significantly and consistently elevated in the curettage and hysterectomy samples of EC relative to normal controls. Furthermore, the overexpression of miR‑205 could predict lymph node metastasis with a high accuracy and was revealed again to be associated with a poor prognosis in EC. Prospective and multicentric studies are required to further clarify the value of miR‑205 as a promising predictor to stratify risk for lymph node metastasis in EC.
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Copy and paste a formatted citation
Spandidos Publications style
Ma YJ, Ha CF, Bai ZM, Li HN, Xiong Y and Jiang J: Overexpression of microRNA-205 predicts lymph node metastasis and indicates an unfavorable prognosis in endometrial cancer. Oncol Lett 12: 4403-4410, 2016.
APA
Ma, Y., Ha, C., Bai, Z., Li, H., Xiong, Y., & Jiang, J. (2016). Overexpression of microRNA-205 predicts lymph node metastasis and indicates an unfavorable prognosis in endometrial cancer. Oncology Letters, 12, 4403-4410. https://doi.org/10.3892/ol.2016.5262
MLA
Ma, Y., Ha, C., Bai, Z., Li, H., Xiong, Y., Jiang, J."Overexpression of microRNA-205 predicts lymph node metastasis and indicates an unfavorable prognosis in endometrial cancer". Oncology Letters 12.6 (2016): 4403-4410.
Chicago
Ma, Y., Ha, C., Bai, Z., Li, H., Xiong, Y., Jiang, J."Overexpression of microRNA-205 predicts lymph node metastasis and indicates an unfavorable prognosis in endometrial cancer". Oncology Letters 12, no. 6 (2016): 4403-4410. https://doi.org/10.3892/ol.2016.5262
Copy and paste a formatted citation
x
Spandidos Publications style
Ma YJ, Ha CF, Bai ZM, Li HN, Xiong Y and Jiang J: Overexpression of microRNA-205 predicts lymph node metastasis and indicates an unfavorable prognosis in endometrial cancer. Oncol Lett 12: 4403-4410, 2016.
APA
Ma, Y., Ha, C., Bai, Z., Li, H., Xiong, Y., & Jiang, J. (2016). Overexpression of microRNA-205 predicts lymph node metastasis and indicates an unfavorable prognosis in endometrial cancer. Oncology Letters, 12, 4403-4410. https://doi.org/10.3892/ol.2016.5262
MLA
Ma, Y., Ha, C., Bai, Z., Li, H., Xiong, Y., Jiang, J."Overexpression of microRNA-205 predicts lymph node metastasis and indicates an unfavorable prognosis in endometrial cancer". Oncology Letters 12.6 (2016): 4403-4410.
Chicago
Ma, Y., Ha, C., Bai, Z., Li, H., Xiong, Y., Jiang, J."Overexpression of microRNA-205 predicts lymph node metastasis and indicates an unfavorable prognosis in endometrial cancer". Oncology Letters 12, no. 6 (2016): 4403-4410. https://doi.org/10.3892/ol.2016.5262
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