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Folate deficiency and aberrant expression of cell adhesion molecule 1 are potential indicators of prognosis in laryngeal squamous cell carcinoma

  • Authors:
    • Hao Chang
    • Min Ma
    • Rui Ma
    • Chao Zhang
    • Wei Zeng
    • Lu Qi Xing
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology, The First Affiliated Hospital, College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan 471003, P.R. China, Department of Central Laboratory, Eye & ENT Hospital of Fudan University, Shanghai 200032, P.R. China, Department of Pathology, The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan 471003, P.R. China
    Copyright: © Chang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4510-4514
    |
    Published online on: October 14, 2016
       https://doi.org/10.3892/ol.2016.5264
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Abstract

The etiology of laryngeal squamous cell carcinoma (LSCC) has not yet been adequately examined. Therefore, the present study aimed to investigate the association between serum folate deficiency and abnormal expression of the cell adhesion molecule 1 (CADM1) protein in the progression of LSCC. Samples were collected from 60 patients with LSCC and 30 healthy people. Radioimmunoassays and immunohistochemical staining were performed to measure serum folate levels and CADM1 protein expression, respectively. The results demonstrated that CADM1 expression in LSCC specimens was significantly lower than in adjacent normal tissues (χ2=28.229, P<0.001), which was associated with histological differentiation and clinical stage (P=0.010 and 0.020, respectively). Levels of serum folate in patients with LSCC were significantly lower than those observed in healthy individuals (P=0.002). Furthermore, TSLCl expression and serum folate levels were positively correlated in LSCC (r=0.642, P=0.001). Thus, the present study determined that decreased CADM1 protein expression and low levels of serum folate were correlated with an increased severity of LSCC.
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1 

Huang XZ, Wang JB and Kong WJ: Practice of Otorhinolaryngology-Head and Neck Surgery. 2nd. People's Medical Publishing House; Bei Jing, China: 2007, View Article : Google Scholar

2 

Murakami Y, Nobukuni T, Tamura K, Maruyama T, Sekiya T, Arai Y, Gomyou H, Tanigami A, Ohki M, Cabin D, et al: Localization of tumor suppressor activity important in nonsmall cell lung carcinoma on chromosome 11q. Proc Natl Acad Sci USA. 95:8153–8158. 1998. View Article : Google Scholar : PubMed/NCBI

3 

Allinen M, Peri L, Kujala S, Lahti-Domenici J, Outila K, Karppinen SM, Launonen V and Winqvist R: Analysis of 11q21-24 loss of heterozygosity candidate target genes in breast cancer: Indications of TSLC1 promoter hypermethylation. Genes Chromosomes Cancer. 34:384–389. 2002. View Article : Google Scholar : PubMed/NCBI

4 

Fong KM, Kida Y, Zimmerman PV, Ikenaga M and Smith PJ: Loss of heterozygosity frequently affects chromosome 17q in non-small cell lung cancer. Cancer Res. 55:4268–4272. 1995.PubMed/NCBI

5 

Zhou L, Jiang W, Ren C, Yin Z, Feng X, Liu W, Tao Q and Yao K: Frequent hypermethylation of RASSF1A and TSLC1 and high viral load of Epstein-Barr Virus DNA in nasopharyngeal carcinoma and matched tumor-adjacent tissues. Neoplasia. 7:809–815. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Kuramochi M, Fukuhara H, Nobukuni T, Kanbe T, Maruyama T, Ghosh HP, Pletcher M, Isomura M, Onizuka M, Kitamura T, et al: TSLC1 is a tumor suppressor gene in human non-small cell lung cancer. Nat Genet. 27:427–430. 2001. View Article : Google Scholar : PubMed/NCBI

7 

Murakami Y: Involvement of a cell adhesion molecule, TSLC1/IGSF4, in human oncogenesis. Cancer Sci. 96:543–552. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Fukuhara H, Kuramochi M, Fukami T, Kasahara K, Furuhata M, Nobukuni T, Maruyama T, Isogai K, Sekiya T, Shuin T, et al: Promoter methylation of TSLC1 and tumor suppression by its gene product in human prostate cancer. Jpn J Cancer Res Jun. 93:605–609. 2002. View Article : Google Scholar

9 

Jansen M, Fukushima N, Rosty C, Walter K, Altink R, Heek TV, Hruban R, Offerhaus JG and Goggins M: Aberrant methylation of the 5′ CpG island of TSLC1 is common in pancreatic ductal adenocarcinoma and is first manifest in high-grade PanlNs. Cancer Biol Ther. 1:293–296. 2002. View Article : Google Scholar : PubMed/NCBI

10 

Kamen B: Folate and antifolate pharmacology. Semin Oncol. 24:(5 Suppl 18). S18-30–S18-39. 1997.

11 

Friso S and Choi SW: Gene-nutrient interactions and DNA methylation. J Nutr. 132:(8 Suppl). 2382S–2387S. 2002.PubMed/NCBI

12 

Allen RH, Stabler SP, Savage DG and Lindenbaum J: Metabolic abnormalities in cobalamin (vitamin B12) and folate deficiency. FASEB J. 7:1344–1353. 1993.PubMed/NCBI

13 

Sie KK, Medline A, van Weel J, Sohn KJ, Choi SW, Croxford R and Kim YI: Effect of maternal and postweaning folic acid supplementation on colorectal cancer risk in the offspring. Gut. 60:1687–1694. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Jennings BA and Willis G: How folate metabolism affects colorectal cancer development and treatment; a story of heterogeneity and pleiotropy. Cancer Lett. 356:224–230. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Kim YI: Role of folate in colon cancer development and progression. J Nutr. 133(11): Suppl 1. 3731S–3739S. 2003.PubMed/NCBI

16 

Choi SW and Mason JB: Folate status: Effects on pathways of colorectal carcinogenesis. J Nutr. 132:(8 Suppl). 2413S–2418S. 2002.PubMed/NCBI

17 

Kim YI: Folate and carcinogenesis: Evidence, mechanisms, and implications. J Nutr Biochem. 10:66–88. 1999. View Article : Google Scholar : PubMed/NCBI

18 

Kuramochi M, Fukuhara H, Nobukuni T, Kanbe T, Maruyama T, Ghosh HP, Pletcher M, Isomura M, Onizuka M, Kitamura T, et al: TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer. Nat Genet. 27:427–430. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Yong M, Yang L, Suyila Q, Han W, Yuan H, Zhao C and Su X: Expression and clinical implications of P53, P63, and P73 protein in malignant tumor of the parotid gland. Turk J Med Sci. 44:875–882. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Yurdakul A, Akyurek N, Yilmaz Ş, Karakaya J, Memİş L and Ozturk C: Prognostic impact of matrix metalloproteinases (MMP-9 and MMP-2) and vascular endothelial growth factor expression in non-small cell lung cancer. Turk J Med Sci. 42:281–288. 2012.

21 

Uchino K, Ito A, Wakayama T, Koma Y, Okada T, Ohbayashi C, Iseki S, Kitamura Y, Tsubota N, Okita Y and Okada M: Clinical implication and prognostic significance of the tumor suppressor TSLC1 gene detected in adenocarcinoma of the lung. Cancer. 98:1002–1007. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Blount BC, Mack MM, Wehr CM, MacGregor JT, Hiatt RA, Wang G, Wickramasinghe SN, Everson RB and Ames BN: Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: Implications for cancer and neuronal damage. Proc Natl Acad Sci USA. 94:3290–3295. 1997. View Article : Google Scholar : PubMed/NCBI

23 

Surace EI, Lusis E, Murakami Y, Scheithauer BW, Perry A and Gutmann DH: Loss of tumor suppressor in lung cancer-1 (TSLC1) expression in meningioma correlates with increased malignancy grade and reduced patient survival. J Neuropathol Exp Neurol. 63:1015–1027. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Steenbergen RD, Kramer D, Braakhuis BJ, Stern PL, Verheijen RH, Meijer CJ and Snijders PJ: TSLC1 gene silencing in cervical cancer cell lines and cervical neoplasia. J Natl Cancer Inst. 96:294–305. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Duthie SJ, Grant G and Narayanan S: Increased uracil misincorporation in lymphocytes from folate-deficient rats. Br J Cancer. 83:1532–1537. 2000. View Article : Google Scholar : PubMed/NCBI

26 

Duthie SJ, Narayanan S, Brand GM, Pirie L and Grant G: Impact of folate deficiency on DNA stability. J Nutr. 132:(8 Suppl). 2444S–2449S. 2002.PubMed/NCBI

27 

Butterworth CE Jr: Effect of folate on cervical cancer. Synergism among risk factors. Ann N Y Acad Sci. 669:293–299. 1992. View Article : Google Scholar : PubMed/NCBI

28 

Mason JB and Levesque T: Folate: Effects on carcinogenesis and the potential for cancer chemoprevention. Oncology (Williston Park). 10:1727–1736, 1742–1744. 1996.PubMed/NCBI

29 

Murakami Y: Functional cloning of a tumor suppressor gene, TSLC1, in human non-small cell lung cancer. Oncogene. 21:6936–6948. 2002. View Article : Google Scholar : PubMed/NCBI

30 

Fukami T, Fukuhara H, Kuramochi M, Maruyama T, Isogai K, Sakamoto M, Takamoto S and Murakami Y: Promoter methylation of the TSLC1 gene in advanced lung tumors and various cancer cell lines. Int J Cancer. 107:53–59. 2003. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chang H, Ma M, Ma R, Zhang C, Zeng W and Xing LQ: Folate deficiency and aberrant expression of cell adhesion molecule 1 are potential indicators of prognosis in laryngeal squamous cell carcinoma. Oncol Lett 12: 4510-4514, 2016.
APA
Chang, H., Ma, M., Ma, R., Zhang, C., Zeng, W., & Xing, L.Q. (2016). Folate deficiency and aberrant expression of cell adhesion molecule 1 are potential indicators of prognosis in laryngeal squamous cell carcinoma. Oncology Letters, 12, 4510-4514. https://doi.org/10.3892/ol.2016.5264
MLA
Chang, H., Ma, M., Ma, R., Zhang, C., Zeng, W., Xing, L. Q."Folate deficiency and aberrant expression of cell adhesion molecule 1 are potential indicators of prognosis in laryngeal squamous cell carcinoma". Oncology Letters 12.6 (2016): 4510-4514.
Chicago
Chang, H., Ma, M., Ma, R., Zhang, C., Zeng, W., Xing, L. Q."Folate deficiency and aberrant expression of cell adhesion molecule 1 are potential indicators of prognosis in laryngeal squamous cell carcinoma". Oncology Letters 12, no. 6 (2016): 4510-4514. https://doi.org/10.3892/ol.2016.5264
Copy and paste a formatted citation
x
Spandidos Publications style
Chang H, Ma M, Ma R, Zhang C, Zeng W and Xing LQ: Folate deficiency and aberrant expression of cell adhesion molecule 1 are potential indicators of prognosis in laryngeal squamous cell carcinoma. Oncol Lett 12: 4510-4514, 2016.
APA
Chang, H., Ma, M., Ma, R., Zhang, C., Zeng, W., & Xing, L.Q. (2016). Folate deficiency and aberrant expression of cell adhesion molecule 1 are potential indicators of prognosis in laryngeal squamous cell carcinoma. Oncology Letters, 12, 4510-4514. https://doi.org/10.3892/ol.2016.5264
MLA
Chang, H., Ma, M., Ma, R., Zhang, C., Zeng, W., Xing, L. Q."Folate deficiency and aberrant expression of cell adhesion molecule 1 are potential indicators of prognosis in laryngeal squamous cell carcinoma". Oncology Letters 12.6 (2016): 4510-4514.
Chicago
Chang, H., Ma, M., Ma, R., Zhang, C., Zeng, W., Xing, L. Q."Folate deficiency and aberrant expression of cell adhesion molecule 1 are potential indicators of prognosis in laryngeal squamous cell carcinoma". Oncology Letters 12, no. 6 (2016): 4510-4514. https://doi.org/10.3892/ol.2016.5264
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