Open Access

Folate deficiency and aberrant expression of cell adhesion molecule 1 are potential indicators of prognosis in laryngeal squamous cell carcinoma

  • Authors:
    • Hao Chang
    • Min Ma
    • Rui Ma
    • Chao Zhang
    • Wei Zeng
    • Lu Qi Xing
  • View Affiliations

  • Published online on: October 14, 2016     https://doi.org/10.3892/ol.2016.5264
  • Pages: 4510-4514
  • Copyright: © Chang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The etiology of laryngeal squamous cell carcinoma (LSCC) has not yet been adequately examined. Therefore, the present study aimed to investigate the association between serum folate deficiency and abnormal expression of the cell adhesion molecule 1 (CADM1) protein in the progression of LSCC. Samples were collected from 60 patients with LSCC and 30 healthy people. Radioimmunoassays and immunohistochemical staining were performed to measure serum folate levels and CADM1 protein expression, respectively. The results demonstrated that CADM1 expression in LSCC specimens was significantly lower than in adjacent normal tissues (χ2=28.229, P<0.001), which was associated with histological differentiation and clinical stage (P=0.010 and 0.020, respectively). Levels of serum folate in patients with LSCC were significantly lower than those observed in healthy individuals (P=0.002). Furthermore, TSLCl expression and serum folate levels were positively correlated in LSCC (r=0.642, P=0.001). Thus, the present study determined that decreased CADM1 protein expression and low levels of serum folate were correlated with an increased severity of LSCC.
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December-2016
Volume 12 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Chang H, Ma M, Ma R, Zhang C, Zeng W and Xing LQ: Folate deficiency and aberrant expression of cell adhesion molecule 1 are potential indicators of prognosis in laryngeal squamous cell carcinoma. Oncol Lett 12: 4510-4514, 2016
APA
Chang, H., Ma, M., Ma, R., Zhang, C., Zeng, W., & Xing, L.Q. (2016). Folate deficiency and aberrant expression of cell adhesion molecule 1 are potential indicators of prognosis in laryngeal squamous cell carcinoma. Oncology Letters, 12, 4510-4514. https://doi.org/10.3892/ol.2016.5264
MLA
Chang, H., Ma, M., Ma, R., Zhang, C., Zeng, W., Xing, L. Q."Folate deficiency and aberrant expression of cell adhesion molecule 1 are potential indicators of prognosis in laryngeal squamous cell carcinoma". Oncology Letters 12.6 (2016): 4510-4514.
Chicago
Chang, H., Ma, M., Ma, R., Zhang, C., Zeng, W., Xing, L. Q."Folate deficiency and aberrant expression of cell adhesion molecule 1 are potential indicators of prognosis in laryngeal squamous cell carcinoma". Oncology Letters 12, no. 6 (2016): 4510-4514. https://doi.org/10.3892/ol.2016.5264