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Article

ATF2 translation is induced under chemotherapeutic drug-mediated cellular stress via an IRES-dependent mechanism in human hepatic cancer Bel7402 cells

  • Authors:
    • Qi Li
    • Wen‑Qing Gao
    • Wen‑Yan Dai
    • Chuang Yu
    • Rui‑Yu Zhu
    • Jian Jin
  • View Affiliations / Copyright

    Affiliations: Laboratory of Molecular Pharmacology, School of Pharmaceutical Sciences, Jiangnan University, Wuxi, Jiangsu 214122, P.R. China
  • Pages: 4795-4802
    |
    Published online on: October 18, 2016
       https://doi.org/10.3892/ol.2016.5274
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Abstract

Activating transcription factor (ATF) 2 is a member of the ATF/cyclic AMP-responsive element binding protein family, which exhibits both oncogenic and tumor‑suppressor functions. In our preliminary experiments, it was observed that the expression of the ATF2 protein was induced following treatment with adriamycin (ADR) and paclitaxel (PTX), which may be regulated by internal ribosome entry segment (IRES)‑mediated translation. By constructing a bicistronic vector containing the ATF2 5'‑untranslated region (UTR), it was demonstrated that the ATF2 5'‑UTR contains an IRES and maps a 30‑nucleotide (nt) sequence (from nt 299 to nt ~269), which was essential for the IRES activity. The ATF2 IRES activity exhibited significant variation in different cell lines. In addition, it was observed that ADR and PTX also induced ATF2 IRES activity in Bel7402 cells. The present study has demonstrated that ATF2 translation is initiated via IRES, which is upregulated by ADR and PTX, thus suggesting that the regulation of the IRES‑dependent translation of ATF2 may be involved in effecting the cancer cell response to chemotherapeutic drugs‑mediated cellular stress.
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1 

Maekawa T, Sakura H, Kanei-Ishii C, Sudo T, Yoshimura T, Fujisawa J, Yoshida M and Ishii S: Leucine zipper structure of the protein CRE-BP1 binding to the cyclic AMP response element in brain. Embo J. 8:2023–2028. 1989.PubMed/NCBI

2 

van Dam H and Castellazzi M: Distinct roles of Jun: Fos and Jun: ATF dimers in oncogenesis. Oncogene. 20:2453–2464. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Maekawa T, Shinagawa T, Sano Y, Sakuma T, Nomura S, Nagasaki K, Miki Y, Saito-Ohara F, Inazawa J, Kohno T, et al: Reduced levels of ATF-2 predispose mice to mammary tumors. Mol Cell Biol. 27:1730–1744. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Bhoumik A and Ronai Z: ATF2: A transcription factor that elicits oncogenic or tumor suppressor activities. Cell Cycle. 7:2341–2345. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Yu T, Li YJ, Bian AH, Zuo HB, Zhu TW, Ji SX, Kong F, Yin de Q, Wang CB, Wang ZF, et al: The regulatory role of activating transcription factor 2 in inflammation. Mediators Inflamm. 2014:9504722014. View Article : Google Scholar : PubMed/NCBI

6 

Morrison DK and Davis RJ: Regulation of MAP kinase signaling modules by scaffold proteins in mammals. Annu Rev Cell Dev Biol. 19:91–118. 2003. View Article : Google Scholar : PubMed/NCBI

7 

van Dam H, Wilhelm D, Herr I, Steffen A, Herrlich P and Angel P: ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents. Embo J. 14:1798–1811. 1995.PubMed/NCBI

8 

Papassava P, Gorgoulis VG, Papaevangeliou D, Vlahopoulos S, van Dam H and Zoumpourlis V: Overexpression of activating transcription factor-2 is required for tumor growth and progression in mouse skin tumors. Cancer Res. 64:8573–8584. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Bhoumik A, Huang TG, Ivanov V, Gangi L, Qiao RF, Woo SL, Chen SH and Ronai Z: An ATF2-derived peptide sensitizes melanomas to apoptosis and inhibits their growth and metastasis. J Clin Invest. 110:643–650. 2002. View Article : Google Scholar : PubMed/NCBI

10 

Liu S, Wang F, Yan L, Zhang L, Song Y, Xi S, Jia J and Sun G: Oxidative stress and MAPK involved into ATF2 expression in immortalized human urothelial cells treated by arsenic. Arch Toxicol. 87:981–989. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Sheikh MS and Fornace AJ Jr: Regulation of translation initiation following stress. Oncogene. 18:6121–6128. 1999. View Article : Google Scholar : PubMed/NCBI

12 

Lackner DH and Bähler J: Translational control of gene expression from transcripts to transcriptomes. Int Rev Cell Mol Biol. 271:199–251. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Shatsky IN, Dmitriev SE, Terenin IM and Andreev DE: Cap- and IRES-independent scanning mechanism of translation initiation as an alternative to the concept of cellular IRESs. Mol Cells. 30:285–293. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Stoneley M and Willis AE: Cellular internal ribosome entry segments: Structures, trans-acting factors and regulation of gene expression. Oncogene. 23:3200–3207. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Hellen CU and Sarnow P: Internal ribosome entry sites in eukaryotic mRNA molecules. Genes Dev. 15:1593–1612. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Komar AA and Hatzoglou M: Internal ribosome entry sites in cellular mRNAs: Mystery of their existence. J Biol Chem. 280:23425–23428. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Oumard A, Hennecke M, Hauser H and Nourbakhsh M: Translation of NRF mRNA is mediated by highly efficient internal ribosome entry. Mol Cell Biol. 20:2755–2759. 2000. View Article : Google Scholar : PubMed/NCBI

18 

Riley A, Jordan LE and Holcik M: Distinct 5′ UTRs regulate XIAP expression under normal growth conditions and during cellular stress. Nucleic Acids Res. 38:4665–4674. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Shiroki K, Ohsawa C, Sugi N, Wakiyama M, Miura K, Watanabe M, Suzuki Y and Sugano S: Internal ribosome entry site-mediated translation of Smad5 in vivo: Requirement for a nuclear event. Nucleic Acids Res. 30:2851–2861. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Baird SD, Turcotte M, Korneluk RG and Holcik M: Searching for IRES. RNA. 12:1755–1785. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Nevins TA, Harder ZM, Korneluk RG and Holcik M: Distinct regulation of internal ribosome entry site-mediated translation following cellular stress is mediated by apoptotic fragments of eIF4G translation initiation factor family members eIF4GI and p97/DAP5/NAT1. J Biol Chem. 278:3572–3579. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Yang L, Gu L, Li Z and Zhou M: Translation of TRAF1 is regulated by IRES-dependent mechanism and stimulated by vincristine. Nucleic Acids Res. 38:4503–4513. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Chan CP, Kok KH, Tang HM, Wong CM and Jin DY: Internal ribosome entry site-mediated translational regulation of ATF4 splice variant in mammalian unfolded protein response. Biochim Biophys Acta. 1833:2165–2175. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Fabrizio C, Stefano M, Laura G, Marco N, Lorenzo M and Antonio O: Re: Baseline and early MR apparent diffusion coefficient quantification as a predictor of response of unresectable hepatocellular carcinoma to doxorubicin drug-eluting bead chemoembolization. J Vasc Interv Radiol. 27:1456–1458. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Chen L, Liu Y, Wang W and Liu K: Effect of integrin receptor-targeted liposomal paclitaxel for hepatocellular carcinoma targeting and therapy. Oncol Lett. 10:77–84. 2015.PubMed/NCBI

26 

Xi G, Hu X, Wu B, Jiang H, Young CY, Pang Y and Yuan H: Autophagy inhibition promotes paclitaxel-induced apoptosis in cancer cells. Cancer Lett. 307:141–148. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Pelletier J and Sonenberg N: Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA. Nature. 334:320–325. 1988. View Article : Google Scholar : PubMed/NCBI

28 

Komar AA and Hatzoglou M: Cellular IRES-mediated translation: The war of ITAFs in pathophysiological states. Cell Cycle. 10:229–240. 2014. View Article : Google Scholar

29 

Gozdecka M, Lyons S, Kondo S, Taylor J, Li Y, Walczynski J, Thiel G, Breitwieser W and Jones N: JNK suppresses tumor formation via a gene-expression program mediated by ATF2. Cell Rep. 9:1361–1374. 2014. View Article : Google Scholar : PubMed/NCBI

30 

De Graeve F, Bahr A, Sabapathy KT, Hauss C, Wagner EF, Kedinger C and Chatton B: Role of the ATFa/JNK2 complex in Jun activation. Oncogene. 18:3491–3500. 1999. View Article : Google Scholar : PubMed/NCBI

31 

Livingstone C, Patel G and Jones N: ATF-2 contains a phosphorylation-dependent transcriptional activation domain. EMBO J. 14:1785–1797. 1995.PubMed/NCBI

32 

Zeke A, Bastys T, Alexa A, Garai Á, Mészáros B, Kirsch K, Dosztányi Z, Kalinina OV and Reményi A: Systematic discovery of linear binding motifs targeting an ancient protein interaction surface on MAP kinases. Mol Syst Biol. 11:8372015. View Article : Google Scholar : PubMed/NCBI

33 

King HA, Cobbold LC and Willis AE: The role of IRES trans-acting factors in regulating translation initiation. Biochem Soc Trans. 38:1581–1586. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Filbin ME and Kieft JS: Toward a structural understanding of IRES RNA function. Curr Opin Struct Biol. 19:267–276. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Komuro I, Schalling M, Jahn L, Bodmer R, Jenkins NA, Copeland NG and Izumo S: Gtx: A novel murine homeobox-containing gene, expressed specifically in glial cells of the brain and germ cells of testis, has a transcriptional repressor activity in vitro for a serum-inducible promoter. EMBO J. 12:1387–1401. 1993.PubMed/NCBI

36 

Hu MC, Tranque P, Edelman GM and Mauro VP: rRNA-complementarity in the 5′ untranslated region of mRNA specifying the Gtx homeodomain protein: Evidence that base-pairing to 18S rRNA affects translational efficiency. Proc Natl Acad Sci USA. 96:1339–1344. 1999. View Article : Google Scholar : PubMed/NCBI

37 

Cencig S, Nanbru C, Le SY, Gueydan C, Huez G and Kruys V: Mapping and characterization of the minimal internal ribosome entry segment in the human c-myc mRNA 5′ untranslated region. Oncogene. 23:267–277. 2004. View Article : Google Scholar : PubMed/NCBI

38 

Schepens B, Tinton SA, Bruynooghe Y, Beyaert R and Cornelis S: The polypyrimidine tract-binding protein stimulates HIF-1alpha IRES-mediated translation during hypoxia. Nucleic Acids Res. 33:6884–6894. 2005. View Article : Google Scholar : PubMed/NCBI

39 

Petz M, Them N, Huber H, Beug H and Mikulits W: La enhances IRES-mediated translation of laminin B1 during malignant epithelial to mesenchymal transition. Nucleic Acids Res. 40:290–302. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Blau L, Knirsh R, Ben-Dror I, Oren S, Kuphal S, Hau P, Proescholdt M, Bosserhoff AK and Vardimon L: Aberrant expression of c-Jun in glioblastoma by internal ribosome entry site (IRES)-mediated translational activation. Proc Natl Acad Sci USA. 109:E2875–E2884. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Shi Y, Sharma A, Wu H, Lichtenstein A and Gera J: Cyclin D1 and c-myc internal ribosome entry site (IRES)-dependent translation is regulated by AKT activity and enhanced by rapamycin through a p38 MAPK- and ERK-dependent pathway. J Biol Chem. 280:10964–10973. 2005. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li Q, Gao WQ, Dai WY, Yu C, Zhu RY and Jin J: ATF2 translation is induced under chemotherapeutic drug-mediated cellular stress via an IRES-dependent mechanism in human hepatic cancer Bel7402 cells. Oncol Lett 12: 4795-4802, 2016.
APA
Li, Q., Gao, W., Dai, W., Yu, C., Zhu, R., & Jin, J. (2016). ATF2 translation is induced under chemotherapeutic drug-mediated cellular stress via an IRES-dependent mechanism in human hepatic cancer Bel7402 cells. Oncology Letters, 12, 4795-4802. https://doi.org/10.3892/ol.2016.5274
MLA
Li, Q., Gao, W., Dai, W., Yu, C., Zhu, R., Jin, J."ATF2 translation is induced under chemotherapeutic drug-mediated cellular stress via an IRES-dependent mechanism in human hepatic cancer Bel7402 cells". Oncology Letters 12.6 (2016): 4795-4802.
Chicago
Li, Q., Gao, W., Dai, W., Yu, C., Zhu, R., Jin, J."ATF2 translation is induced under chemotherapeutic drug-mediated cellular stress via an IRES-dependent mechanism in human hepatic cancer Bel7402 cells". Oncology Letters 12, no. 6 (2016): 4795-4802. https://doi.org/10.3892/ol.2016.5274
Copy and paste a formatted citation
x
Spandidos Publications style
Li Q, Gao WQ, Dai WY, Yu C, Zhu RY and Jin J: ATF2 translation is induced under chemotherapeutic drug-mediated cellular stress via an IRES-dependent mechanism in human hepatic cancer Bel7402 cells. Oncol Lett 12: 4795-4802, 2016.
APA
Li, Q., Gao, W., Dai, W., Yu, C., Zhu, R., & Jin, J. (2016). ATF2 translation is induced under chemotherapeutic drug-mediated cellular stress via an IRES-dependent mechanism in human hepatic cancer Bel7402 cells. Oncology Letters, 12, 4795-4802. https://doi.org/10.3892/ol.2016.5274
MLA
Li, Q., Gao, W., Dai, W., Yu, C., Zhu, R., Jin, J."ATF2 translation is induced under chemotherapeutic drug-mediated cellular stress via an IRES-dependent mechanism in human hepatic cancer Bel7402 cells". Oncology Letters 12.6 (2016): 4795-4802.
Chicago
Li, Q., Gao, W., Dai, W., Yu, C., Zhu, R., Jin, J."ATF2 translation is induced under chemotherapeutic drug-mediated cellular stress via an IRES-dependent mechanism in human hepatic cancer Bel7402 cells". Oncology Letters 12, no. 6 (2016): 4795-4802. https://doi.org/10.3892/ol.2016.5274
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