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Cisplatin induces HepG2 cell cycle arrest through targeting specific long noncoding RNAs and the p53 signaling pathway

  • Authors:
    • Ping Wang
    • Jiayue Cui
    • Jihong Wen
    • Yunhui Guo
    • Liangzi Zhang
    • Xia Chen
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology‑Head and Neck Surgery, First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Department of Histology and Embryology, College of Basic Medical Sciences Jilin University, Changchun, Jilin 130021, P.R. China, Department of Gynaecology and Obstetrics, First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Department of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun, Jilin 130021, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4605-4612
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    Published online on: October 18, 2016
       https://doi.org/10.3892/ol.2016.5288
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Abstract

Cisplatin has been used effectively in the treatment of hepatocellular carcinoma (HCC). Long noncoding RNAs (lncRNAs) were recently reported to contribute to the pathogenesis and progression of HCC. Their molecular mechanism related to cisplatin treatment remains unclear. The purpose of this study is to identify specific lncRNAs and to clarify their functions in HCC after cisplatin exposure. Reannotation and identification of differentially expressed lncRNAs were performed using the microarray data set GSE38122 in the Gene Expression Omnibus database. Four significantly differentially expressed lncRNAs (RP11‑134G8.8, RP11‑612B6.2, RP11‑363E7.4 and RP1‑193H18.2) were identified in HepG2 cells exposed to cisplatin by bioinformatics methods. The upregulated RP11‑134G8.8 and RP11‑363E7.4 and the downregulated RP1‑193H18.2 were confirmed by reverse transcription‑quantitative polymerase chain reaction. Furthermore, 57 significant co‑expressing genes and their corresponding pathways were annotated and identified. The p53 signaling pathway showed the most significant difference among all pathways. Based on these results, the cell cycle and three key genes, cyclin‑dependent kinase inhibitor 1A (CDKN1A, also known as p21), tumor protein p53 inducible protein 3 (TP53I3) and wild‑type p53‑induced phosphatase 1 (Wip1, also known as PPM1D), were examined. CDKN1A, TP53I3 and PPM1D were all downregulated by RP1‑193H18.2 but upregulated by RP11‑134G8.8 and RP11‑363E7.4. And obvious S phase arrest was induced by cisplatin treatment for 24 h in HepG2 cells. Finally, the immunofluorescence results showed upregulation of TP53I3 and Wip1 and downregulation of p21 at the protein level. The results suggested that the lncRNAs RP11‑134G8.8, RP11‑363E7.4 and RP1‑193H18.2, and their co‑expression genes, which annotated into the p53 signaling pathway, could be potential targets for cisplatin treatment.
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1 

Hou JK, Huang Y, He W, Yan ZW, Fan L, Liu MH, Xiao WL, Sun HD and Chen GQ: Adenanthin targets peroxiredoxin I/II to kill hepatocellular carcinoma cells. Cell Death Dis. 5:e14002014. View Article : Google Scholar : PubMed/NCBI

2 

Yang X, Xie X, Xiao YF, Xie R, Hu CJ, Tang B, Li BS and Yang SM: The emergence of long non-coding RNAs in the tumorigenesis of hepatocellular carcinoma. Cancer Lett. 360:119–124. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Marullo R, Werner E, Degtyareva N, Moore B, Altavilla G, Ramalingam SS and Doetsch PW: Cisplatin induces a mitochondrial-ROS response that contributes to cytotoxicity depending on mitochondrial redox status and bioenergetic functions. PLoS One. 8:e811622013. View Article : Google Scholar : PubMed/NCBI

4 

Wang Y, Liu Y, Liu Y, Zhou W, Wang H, Wan G, Sun D, Zhang N and Wang Y: A polymeric prodrug of cisplatin based on pullulan for the targeted therapy against hepatocellular carcinoma. Int J Pharm. 483:89–100. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Ziko L, Riad S, Amer M, Zdero R, Bougherara H and Amleh A: Mechanical stress promotes cisplatin-induced hepatocellular carcinoma cell death. Biomed Res Int. 2015:4305692015. View Article : Google Scholar : PubMed/NCBI

6 

Bose RN: Biomolecular targets for platinum antitumor drugs. Mini Rev Med Chem. 2:103–111. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Chu G: Cellular responses to cisplatin. The roles of DNA-binding proteins and DNA repair. J Biol Chem. 269:787–790. 1994.PubMed/NCBI

8 

Galluzzi L, Senovilla L, Vitale I, Michels J, Martins I, Kepp O, Castedo M and Kroemer G: Molecular mechanisms of cisplatin resistance. Oncogene. 31:1869–1883. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Bonasio R and Shiekhattar R: Regulation of transcription by long noncoding RNAs. Annu Rev Genet. 48:433–455. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Kung JT, Colognori D and Lee JT: Long noncoding RNAs: Past, present and future. Genetics. 193:651–669. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Shi D, Zheng H, Zhuo C, Peng J, Li D, Xu Y, Li X, Cai G and Cai S: Low expression of novel lncRNA RP11-462C24.1 suggests a biomarker of poor prognosis in colorectal cancer. Med Oncol. 31:312014. View Article : Google Scholar : PubMed/NCBI

12 

Sun M and Kraus WL: From discovery to function: The expanding roles of long noncoding RNAs in physiology and disease. Endocr Rev. 36:25–64. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Fan Y, Shen B, Tan M, Mu X, Qin Y, Zhang F and Liu Y: Long non-coding RNA UCA1 increases chemoresistance of bladder cancer cells by regulating Wnt signaling. FEBS J. 281:1750–1758. 2014. View Article : Google Scholar : PubMed/NCBI

14 

George J and Patel T: Noncoding RNA as therapeutic targets for hepatocellular carcinoma. Semin Liver Dis. 35:63–74. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Liao Q, Xiao H, Bu D, Xie C, Miao R, Luo H, Zhao G, Yu K, Zhao H, Skogerbø G, et al: ncFANs: A web server for functional annotation of long non-coding RNAs. Nucleic Acids Res. 39:W118–W124. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Hou Z, Xu C, Xie H, Xu H, Zhan P, Yu L and Fang X: Long noncoding RNAs expression patterns associated with chemo response to cisplatin based chemotherapy in lung squamous cell carcinoma patients. PLoS One. 9:e1081332014. View Article : Google Scholar : PubMed/NCBI

17 

Sui W, Yan Q, Li H, Liu J, Chen J, Li L and Dai Y: Genome-wide analysis of long noncoding RNA expression in peripheral blood mononuclear cells of uremia patients. J Nephrol. 26:731–738. 2013. View Article : Google Scholar : PubMed/NCBI

18 

da W Huang, Sherman BT and Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 4:44–57. 2009.PubMed/NCBI

19 

Ponting CP, Oliver PL and Reik W: Evolution and functions of long noncoding RNAs. Cell. 136:629–641. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Hall JR, Messenger ZJ, Tam HW, Phillips SL, Recio L and Smart RC: Long noncoding RNA lincRNA-p21 is the major mediator of UVB-induced and p53-dependent apoptosis in keratinocytes. Cell Death Dis. 6:e17002015. View Article : Google Scholar : PubMed/NCBI

21 

Foo JB, Yazan LS, Tor YS, Wibowo A, Ismail N, How CW, Armania N, Loh SP, Ismail IS, Cheah YK and Abdullah R: Induction of cell cycle arrest and apoptosis by betulinic acid-rich fraction from Dillenia suffruticosa root in MCF-7 cells involved p53/p21 and mitochondrial signalling pathway. J Ethnopharmacol. 166:270–278. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Ma X, Han J, Wu Q, Liu H, Shi S, Wang C, Wang Y, Xiao J, Zhao J, Jiang J and Wan C: Involvement of dysregulated Wip1 in manganese-induced p53 signaling and neuronal apoptosis. Toxicol Lett. 235:17–27. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Flatt PM, Polyak K, Tang LJ, Scatena CD, Westfall MD, Rubinstein LA, Yu J, Kinzler KW, Vogelstein B, Hill DE and Pietenpol JA: p53-dependent expression of PIG3 during proliferation, genotoxic stress and reversible growth arrest. Cancer Lett. 156:63–72. 2000. View Article : Google Scholar : PubMed/NCBI

24 

Gartel AL and Radhakrishnan SK: Lost in transcription: p21 repression, mechanisms and consequences. Cancer Res. 65:3980–3985. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Ando T, Kawabe T, Ohara H, Ducommun B, Itoh M and Okamoto T: Involvement of the interaction between p21 and proliferating cell nuclear antigen for the maintenance of G2/M arrest after DNA damage. J Biol Chem. 276:42971–42977. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Yadav V, Sultana S, Yadav J and Saini N: Gatifloxacin induces S and G2-phase cell cycle arrest in pancreatic cancer cells via p21/p27/p53. PLoS One. 7:e477962012. View Article : Google Scholar : PubMed/NCBI

27 

Qu K, Lin T, Wei J, Meng F, Wang Z, Huang Z, Wan Y, Song S, Liu S, Chang H, et al: Cisplatin induces cell cycle arrest and senescence via upregulating P53 and P21 expression in HepG2 cells. Nan Fang Yi Ke Da Xue Xue Bao. 33:1253–1259. 2013.PubMed/NCBI

28 

Wang C, Chen Z, Ge Q, Hu J, Li F, Hu J, Xu H, Ye Z and Li LC: Up-regulation of p21 (WAF1/CIP1) by miRNAs and its implications in bladder cancer cells. FEBS Lett. 588:4654–4664. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Zhang H, Zhang X, Ji S, Hao C, Mu Y, Sun J and Hao J: Sohlh2 inhibits ovarian cancer cell proliferation by upregulation of p21 and downregulation of cyclin D1. Carcinogenesis. 35:1863–1871. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Liu Z, Sun M, Lu K, Liu J, Zhang M, Wu W, De W, Wang Z and Wang R: The long noncoding RNA HOTAIR contributes to cisplatin resistance of human lung adenocarcinoma cells via downregualtion of p21 (WAF1/CIP1) expression. PLoS One. 8:e772932013. View Article : Google Scholar : PubMed/NCBI

31 

Contente A, Dittmer A, Koch MC, Roth J and Dobbelstein M: A polymorphic microsatellite that mediates induction of PIG3 by p53. Nat Genet. 30:315–320. 2002. View Article : Google Scholar : PubMed/NCBI

32 

Guan X, Liu Z, Wang L, Wang LE, Sturgis EM and Wei Q: Functional repeats (TGYCC)n in the p53-inducible gene 3 (PIG3) promoter and susceptibility to squamous cell carcinoma of the head and neck. Carcinogenesis. 34:812–817. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Li B, Shang ZF, Yin JJ, Xu QZ, Liu XD, Wang Y, Zhang SM, Guan H and Zhou PK: PIG3 functions in DNA damage response through regulating DNA-PKcs homeostasis. Int J Biol Sci. 9:425–434. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Shaltiel IA, Aprelia M, Saurin AT, Chowdhury D, Kops GJ, Voest EE and Medema RH: Distinct phosphatases antagonize the p53 response in different phases of the cell cycle. Proc Natl Acad Sci USA. 111:7313–7318. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Lowe J, Cha H, Lee MO, Mazur SJ, Appella E and Fornace AJ Jr: Regulation of the Wip1 phosphatase and its effects on the stress response. Front Biosci (Landmark Ed). 17:1480–1498. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Wang W, Zhu H, Zhang H, Zhang L, Ding Q and Jiang H: Targeting PPM1D by lentivirus-mediated RNA interference inhibits the tumorigenicity of bladder cancer cells. Braz J Med Biol Res. 47:1044–1049. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Li GB, Zhang XL, Yuan L, Jiao QQ, Liu DJ and Liu J: Protein phosphatase magnesium-dependent 1delta (PPM1D) mRNA expression is a prognosis marker for hepatocellular carcinoma. PLoS One. 8:e607752013. View Article : Google Scholar : PubMed/NCBI

38 

Yagi H, Chuman Y, Kozakai Y, Imagawa T, Takahashi Y, Yoshimura F, Tanino K and Sakaguchi K: A small molecule inhibitor of p53-inducible protein phosphatase PPM1D. Bioorg Med Chem Lett. 22:729–732. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Tan DS, Lambros MB, Rayter S, Natrajan R, Vatcheva R, Gao Q, Marchio C, Geyer FC, Savage K, Parry S, et al: PPM1D is a potential therapeutic target in ovarian clear cell carcinomas. Clin Cancer Res. 15:2269–2280. 2009. View Article : Google Scholar : PubMed/NCBI

40 

Peng TS, He YH, Nie T, Hu XD, Lu HY, Yi J, Shuai YF and Luo M: PPM1D is a prognostic marker and therapeutic target in colorectal cancer. Exp Ther Med. 8:430–434. 2014.PubMed/NCBI

41 

Ali AY, Kim JY, Pelletier JF, Vanderhyden BC, Bachvarov DR and Tsang BK: Akt confers cisplatin chemoresistance in human gynecological carcinoma cells by modulating PPM1D stability. Mol Carcinog. 54:1301–1314. 2015. View Article : Google Scholar : PubMed/NCBI

42 

Park HK, Panneerselvam J, Dudimah FD, Dong G, Sebastian S, Zhang J and Fei P: Wip1 contributes to cell homeostasis maintained by the steady-state level of Wtp53. Cell Cycle. 10:2574–2582. 2011. View Article : Google Scholar : PubMed/NCBI

43 

Cao R, Zhang J, Zhang M and Chen X: PPM1D regulates p21 expression via dephoshporylation at serine 123. Cell Cycle. 14:641–647. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang P, Cui J, Wen J, Guo Y, Zhang L and Chen X: Cisplatin induces HepG2 cell cycle arrest through targeting specific long noncoding RNAs and the p53 signaling pathway. Oncol Lett 12: 4605-4612, 2016.
APA
Wang, P., Cui, J., Wen, J., Guo, Y., Zhang, L., & Chen, X. (2016). Cisplatin induces HepG2 cell cycle arrest through targeting specific long noncoding RNAs and the p53 signaling pathway. Oncology Letters, 12, 4605-4612. https://doi.org/10.3892/ol.2016.5288
MLA
Wang, P., Cui, J., Wen, J., Guo, Y., Zhang, L., Chen, X."Cisplatin induces HepG2 cell cycle arrest through targeting specific long noncoding RNAs and the p53 signaling pathway". Oncology Letters 12.6 (2016): 4605-4612.
Chicago
Wang, P., Cui, J., Wen, J., Guo, Y., Zhang, L., Chen, X."Cisplatin induces HepG2 cell cycle arrest through targeting specific long noncoding RNAs and the p53 signaling pathway". Oncology Letters 12, no. 6 (2016): 4605-4612. https://doi.org/10.3892/ol.2016.5288
Copy and paste a formatted citation
x
Spandidos Publications style
Wang P, Cui J, Wen J, Guo Y, Zhang L and Chen X: Cisplatin induces HepG2 cell cycle arrest through targeting specific long noncoding RNAs and the p53 signaling pathway. Oncol Lett 12: 4605-4612, 2016.
APA
Wang, P., Cui, J., Wen, J., Guo, Y., Zhang, L., & Chen, X. (2016). Cisplatin induces HepG2 cell cycle arrest through targeting specific long noncoding RNAs and the p53 signaling pathway. Oncology Letters, 12, 4605-4612. https://doi.org/10.3892/ol.2016.5288
MLA
Wang, P., Cui, J., Wen, J., Guo, Y., Zhang, L., Chen, X."Cisplatin induces HepG2 cell cycle arrest through targeting specific long noncoding RNAs and the p53 signaling pathway". Oncology Letters 12.6 (2016): 4605-4612.
Chicago
Wang, P., Cui, J., Wen, J., Guo, Y., Zhang, L., Chen, X."Cisplatin induces HepG2 cell cycle arrest through targeting specific long noncoding RNAs and the p53 signaling pathway". Oncology Letters 12, no. 6 (2016): 4605-4612. https://doi.org/10.3892/ol.2016.5288
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