Open Access

The role of T‑box genes in the tumorigenesis and progression of cancer (Review)

  • Authors:
    • Fangyuan Chang
    • Peipei Xing
    • Fengju Song
    • Xiaoling Du
    • Guowen Wang
    • Kexin Chen
    • Jilong Yang
  • View Affiliations

  • Published online on: October 19, 2016     https://doi.org/10.3892/ol.2016.5296
  • Pages: 4305-4311
  • Copyright: © Chang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The T-box (TBX) genes are part of an evolutionarily conserved family of transcription factors involved in organ development. They serve key roles in a number of molecular mechanisms, including proliferation, cell fate and organ identity. In addition, previous studies suggest that TBX genes have essential functions in the tumorigenesis and progression of various types of cancer. For example, TBX proteins served significant roles in carcinogenesis, proliferation and differentiation, senescence and apoptosis, invasion and migration, mesenchymal‑epithelial and epithelial‑mesenchymal transition, oncogenic signaling pathways and drug sensitivity. However, the exact mechanisms by which TBX genes carry out these functions have not yet been fully elucidated. The present review focuses on the role of TBX genes in cancer, with the aim of further clarifying their function. As altered levels of TBX proteins have detrimental consequences in numerous types of cancer, there is a need for further research into TBX genes, which this review may aid through providing a comprehensive insight into the topic.
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December-2016
Volume 12 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Chang F, Xing P, Song F, Du X, Wang G, Chen K and Yang J: The role of T‑box genes in the tumorigenesis and progression of cancer (Review). Oncol Lett 12: 4305-4311, 2016
APA
Chang, F., Xing, P., Song, F., Du, X., Wang, G., Chen, K., & Yang, J. (2016). The role of T‑box genes in the tumorigenesis and progression of cancer (Review). Oncology Letters, 12, 4305-4311. https://doi.org/10.3892/ol.2016.5296
MLA
Chang, F., Xing, P., Song, F., Du, X., Wang, G., Chen, K., Yang, J."The role of T‑box genes in the tumorigenesis and progression of cancer (Review)". Oncology Letters 12.6 (2016): 4305-4311.
Chicago
Chang, F., Xing, P., Song, F., Du, X., Wang, G., Chen, K., Yang, J."The role of T‑box genes in the tumorigenesis and progression of cancer (Review)". Oncology Letters 12, no. 6 (2016): 4305-4311. https://doi.org/10.3892/ol.2016.5296