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Comparison of microRNA expression profiles in K562-cells-derived microvesicles and parental cells, and analysis of their roles in leukemia

  • Authors:
    • Xiaomei Chen
    • Wei Xiong
    • Huiyu Li
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    Affiliations: Center for Biotherapy, Gansu Provincial Hospital, Lanzhou, Gansu 730000, P.R. China, Center of Clinical Laboratory, The Second Affiliated Hospital of Zhejiang University School of Medicine at Binjiang, Hangzhou, Zhejiang 310009, P.R. China, Center for Stem Cell Research and Application, Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4937-4948
    |
    Published online on: October 24, 2016
       https://doi.org/10.3892/ol.2016.5308
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Abstract

Microvesicles (MVs) are 30-1,000‑nm extracellular vesicles that are released from a multitude of cell types and perform diverse cellular functions, including intercellular communication, antigen presentation, and transfer of proteins, messenger RNA and microRNA (also known as miR). MicroRNAs have been demonstrated to be aberrantly expressed in leukemia, and the overall microRNA expression profile may differentiate normal blood cells vs. leukemia cells. MVs containing microRNAs may enable intercellular cross‑talk in vivo. This prompted us to investigate specific variations of microRNA expression patterns in MVs derived from leukemia cells. The present study examined the microRNA expression profile of MVs from chronic myeloid leukemia K562 cells and that of MVs from normal human volunteers' peripheral blood cells. The potential targets of the differentially expressed microRNAs were predicted using computational searches. Bioinformatic analyses of the predicted target genes were performed for further evaluation. The present study analyzed microRNAs of MVs derived from leukemia and normal cells, and characterized specific microRNAs expression. The results revealed that MVs derived from K562 cells expressed 181 microRNAs of the 888 microRNAs assessed. Further analysis revealed that 16 microRNAs were downregulated, while 7 were upregulated in these MVs. In addition, significant differences in microRNA expression profiles between MVs derived from K562 cells and K562 cells were identified. The present results revealed that 77 and 122 microRNAs were only expressed in MVs derived from K562 cells and in K562 cells, respectively. There were 104 microRNAs co‑expressed in MVs derived from K562 cells and in K562 cells. Target gene‑related pathway analyses demonstrated that the majority of the dysregulated microRNAs were involved in pathways associated with leukemia, particularly the mitogen‑activated protein kinase (MAPK) and the p53 signaling pathways. By further conducting microRNA gene network analysis, the present study revealed that the miR‑15a/b, miR‑16, miR‑17 and miR‑30 families were likely to play a role in the regulation of the MAPK signaling pathway. Since K562 cells presented the t(9;22) translocation, the current study further examined the predicted function of 12 microRNAs located in chromosomes 9 [Homo sapiens (hsa)‑let‑7a, hsa‑let‑7f, miR‑126, miR‑126*, miR‑23b, miR‑24, miR‑27b and miR‑7] and 22 (hsa‑let‑7b, miR‑1249, miR‑130b and miR‑185), which were expressed both in MVs derived from K562 cells and in K562 cells. The present study identified microRNAs of MVs from leukemia and normal cells, and characterized the expression of specific microRNAs. The current study is also the first to identify and characterize distinct microRNA expression between MVs derived from K562 cells and K562 cells. These findings highlight that a number of microRNAs from leukemia‑derived MVs may contribute to the development of hematopoietic malignancies. Further investigation may reveal the function of these differentially expressed microRNAs and may provide potential targets for novel therapeutic strategies.
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View References

1 

Zhou JB, Zhang T, Wang BF, Gao HZ and Xu X: Identification of a novel gene fusion RNF213SLC26A11 in chronic myeloid leukemia by RNA-Seq. Mol Med Rep. 7:591–597. 2013.PubMed/NCBI

2 

Apperley JF: Chronic myeloid leukaemia. Lancet. 385:1447–1459. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Sasaki K and Mitani K: Molecular pathogenesis of chronic myeloid leukemia. Nihon Rinsho. 67:1894–1899. 2009.(In Japanese). PubMed/NCBI

4 

Belting M and Christianson HC: Role of exosomes and microvesicles in hypoxia-associated tumour development and cardiovascular disease. J Intern Med. 278:251–263. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Lo Cicero A, Schiera G, Proia P, Saladino P, Savettieri G, Di Liegro CM and Di Liegro I: Oligodendroglioma cells shed microvesicles which contain TRAIL as well as molecular chaperones and induce cell death in astrocytes. Int J Oncol. 39:1353–1357. 2011.PubMed/NCBI

6 

Lee TH, D'Asti E, Magnus N, Al-Nedawi K, Meehan B and Rak J: Microvesicles as mediators of intercellular communication in cancer-the emerging science of cellular ‘debris’. Semin Immunopathol. 33:455–467. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Pilzer D, Gasser O, Moskovich O, Schifferli JA and Fishelson Z: Emission of membrane vesicles: Roles in complement resistance, immunity and cancer. Springer Semin Immunopathol. 27:375–387. 2005. View Article : Google Scholar : PubMed/NCBI

8 

EL Andaloussi S, Mäger I, Breakefield XO and Wood MJ: Extracellular vesicles: Biology and emerging therapeutic opportunities. Nat Rev Drug Discov. 12:347–357. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Al-Nedawi K, Meehan B, Micallef J, Lhotak V, May L, Guha A and Rak J: Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells. Nat Cell Biol. 10:619–624. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Skog J, Würdinger T, van Rijn S, Meijer DH, Gainche L, Sena-Esteves M, Curry WT Jr, Carter BS, Krichevsky AM and Breakefield XO: Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol. 10:1470–1476. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Pisetsky DS, Gauley J and Ullal AJ: Microparticles as a source of extracellular DNA. Immunol Res. 49:227–234. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Valadi H, Ekström K, Bossios A, Sjöstrand M, Lee JJ and Lötvall JO: Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 9:654–659. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Taverna S, Flugy A, Saieva L, Kohn EC, Santoro A, Meraviglia S, De Leo G and Alessandro R: Role of exosomes released by chronic myelogenous leukemia cells in angiogenesis. Int J Cancer. 130:2033–2043. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Mineo M, Garfield SH, Taverna S, Flugy A, De Leo G, Alessandro R and Kohn EC: Exosomes released by K562 chronic myeloid leukemia cells promote angiogenesis in a Src-dependent fashion. Angiogenesis. 15:33–45. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Szczepanski MJ, Szajnik M, Welsh A, Whiteside TL and Boyiadzis M: Blast-derived microvesicles in sera from patients with acute myeloid leukemia suppress natural killer cell function via membrane-associated transforming growth factor-beta1. Haematologica. 96:1302–1309. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Hunter MP, Ismail N, Zhang X, Aguda BD, Lee EJ, Yu L, Xiao T, Schafer J, Lee ML, Schmittgen TD, et al: Detection of microRNA expression in human peripheral blood microvesicles. PLoS One. 3:e36942008. View Article : Google Scholar : PubMed/NCBI

17 

Taylor DD and Gercel-Taylor C: MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer. Gynecol Oncol. 110:13–21. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Wysoczynski M and Ratajczak MZ: Lung cancer secreted microvesicles: Underappreciated modulators of microenvironment in expanding tumors. Int J Cancer. 125:1595–1603. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Hayes J, Peruzzi PP and Lawler S: MicroRNAs in cancer: Biomarkers, functions and therapy. Trends Mol Med. 20:460–469. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D, Sweet-Cordero A, Ebert BL, Mak RH, Ferrando AA, et al: MicroRNA expression profiles classify human cancers. Nature. 435:834–838. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Volinia S, Galasso M, Costinean S, Tagliavini L, Gamberoni G, Drusco A, Marchesini J, Mascellani N, Sana ME, Abu Jarour R, et al: Reprogramming of miRNA networks in cancer and leukemia. Genome Res. 20:589–599. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Ramkissoon SH, Mainwaring LA, Ogasawara Y, Keyvanfar K, McCoy JP Jr, Sloand EM, Kajigaya S and Young NS: Hematopoietic-specific microRNA expression in human cells. Leuk Res. 30:643–647. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Venturini L, Battmer K, Castoldi M, Schultheis B, Hochhaus A, Muckenthaler MU, Ganser A, Eder M and Scherr M: Expression of the miR-17-92 polycistron in chronic myeloid leukemia (CML) CD34+ cells. Blood. 109:4399–4405. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Taylor DD and Gerçel-Taylor C: Tumour-derived exosomes and their role in cancer-associated T-cell signalling defects. Br J Cancer. 92:305–311. 2005.PubMed/NCBI

25 

Kosaka N, Iguchi H, Yoshioka Y, Takeshita F, Matsuki Y and Ochiya T: Secretory mechanisms and intercellular transfer of MicroRNAs in living Cells. J Biol Chem. 285:17442–17452. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Chen CZ, Li L, Lodish HF and Bartel DP: MicroRNAs modulate hematopoietic lineage differentiation. Science. 303:83–86. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Li T, Lu YY, Zhao XD, Guo HQ, Liu CH, Li H, Zhou L, Han YN, Wu KC, Nie YZ, et al: MicroRNA-296-5p increases proliferation in gastric cancer through repression of Caudal-related homeobox 1. Onocgene. 33:783–793. 2014. View Article : Google Scholar

28 

Li WY, Chen XM, Xiong W, Guo DM, Lu L and Li HY: Detection of microvesicle miRNA expression in ALL subtypes and analysis of their functional roles. J Huazhong Univ Sci Technolog Med Sci. 34:640–645. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Sun L, Hu J, Xiong W, Chen X, Li H and Jie S: MicroRNA expression profiles of circulating microvesicles in hepatocellular carcinoma. Acta Gastroenterol Belg. 76:386–392. 2013.PubMed/NCBI

30 

Zhang L, Valencia C, Dong B, Chen M, Guan P and Pan L: Transfer of microRNAs by extracellular membrane microvesicles: A nascent crosstalk model in tumor pathogenesis, especially tumor cell-microenvironment interactions. J Hematol Oncol. 8:142015. View Article : Google Scholar : PubMed/NCBI

31 

Giusti I, D'Ascenzo S and Dolo V: Microvesicles as potential ovarian cancer biomarkers. Biomed Res Int. 2013:7030482013. View Article : Google Scholar : PubMed/NCBI

32 

Nieuwland R, Berckmans RJ, McGregor S, Böing AN, Romijn FP, Westendorp RG, Hack CE and Sturk A: Cellular origin and procoagulant properties of microparticles in meningococcal sepsis. Blood. 95:930–935. 2000.PubMed/NCBI

33 

Vaz C, Ahmad HM, Sharma P, Gupta R, Kumar L, Kulshreshtha R and Bhattacharya A: Analysis of microRNA transcriptome by deep sequencing of small RNA libraries of peripheral blood. BMC Genomics. 11:2882010. View Article : Google Scholar : PubMed/NCBI

34 

Linderholm B, Norberg T and Bergh J: Sequencing of the tumor suppressor gene TP 53. Methods Mol Med. 120:389–401. 2006.PubMed/NCBI

35 

Di Bacco A, Keeshan K, McKenna SL and Cotter TG: Molecular abnormalities in chronic myeloid leukemia: Deregulation of cell growth and apoptosis. Oncologist. 5:405–415. 2000. View Article : Google Scholar : PubMed/NCBI

36 

Gilbert F: Disease genes and chromosomes: Disease maps of the human genome. Chromosome 22. Genet Test. 2:89–97. 1998.PubMed/NCBI

37 

Gilbert F and Kauff N: Disease genes and chromosomes: Disease maps of the human genome. Chromosome 9. Genet Test. 5:157–174. 2001. View Article : Google Scholar : PubMed/NCBI

38 

Chai JH, Zhang Y, Tan WH, Chng WJ, Li B and Wang X: Regulation of hTERT by BCR-ABL at multiple levels in K562 cells. BMC Cancer. 11:5122011. View Article : Google Scholar : PubMed/NCBI

39 

Zhou Q, Gallagher R, Ufret-Vincenty R, Li X, Olson EN and Wang S: Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23~27~24 clusters. Proc Natl Acad Sci USA. 108:8287–8292. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Pospisil V, Vargova K, Kokavec J, Rybarova J, Savvulidi F, Jonasova A, Necas E, Zavadil J, Laslo P and Stopka T: Epigenetic silencing of the oncogenic miR-17-92 cluster during PU.1-directed macrophage differentiation. Embo J. 30:4450–4464. 2011. View Article : Google Scholar : PubMed/NCBI

41 

Lawrie CH, Chi J, Taylor S, Tramonti D, Ballabio E, Palazzo S, Saunders NJ, Pezzella F, Boultwood J, Wainscoat JS and Hatton CS: Expression of microRNAs in diffuse large B cell lymphoma is associated with immunophenotype, survival and transformation from follicular lymphoma. J Cell Mol Med. 13:1248–1260. 2009. View Article : Google Scholar : PubMed/NCBI

42 

Zhao H, Wang D, Du W, Gu D and Yang R: MicroRNA and leukemia: Tiny molecule, great function. Crit Rev Oncol Hematol. 74:149–155. 2010. View Article : Google Scholar : PubMed/NCBI

43 

Cammarata G, Augugliaro L, Salemi D, Agueli C, La Rosa M, Dagnino L, Civiletto G, Messana F, Marfia A, Bica MG, et al: Differential expression of specific microRNA and their targets in acute myeloid leukemia. Am J Hematol. 85:331–339. 2010.PubMed/NCBI

44 

Zenz T, Mohr J, Edelmann J, Sarno A, Hoth P, Heuberger M, Helfrich H, Mertens D, Dohner H and Stilgenbauer S: Treatment resistance in chronic lymphocytic leukemia: The role of the p53 pathway. Leuk Lymphoma. 50:510–513. 2009. View Article : Google Scholar : PubMed/NCBI

45 

Wang X, Pesakhov S, Weng A, Kafka M, Gocek E, Nguyen M, Harrison JS, Danilenko M and Studzinski GP: ERK 5/MAPK pathway has a major role in 1α,25-(OH)2 vitamin D3-induced terminal differentiation of myeloid leukemia cells. J Steroid Biochem Mol Biol. 144:223–227. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Caye A, Strullu M, Guidez F, Cassinat B, Gazal S, Fenneteau O, Lainey E, Nouri K, Nakhaei-Rad S, Dvorsky R, et al: Juvenile myelomonocytic leukemia displays mutations in components of the RAS pathway and the PRC2 network. Nat Genet. 47:1334–1340. 2015. View Article : Google Scholar : PubMed/NCBI

47 

Ufkin ML, Peterson S, Yang X, Driscoll H, Duarte C and Sathyanarayana P: miR-125a regulates cell cycle, proliferation, and apoptosis by targeting the ErbB pathway in acute myeloid leukemia. Leuk Res. 38:402–410. 2014. View Article : Google Scholar : PubMed/NCBI

48 

Hornakova T, Staerk J, Royer Y, Flex E, Tartaglia M, Constantinescu SN, Knoops L and Renauld JC: Acute lymphoblastic leukemia-associated JAK1 mutants activate the Janus kinase/STAT pathway via interleukin-9 receptor alpha homodimers. J Biol Chem. 284:6773–6781. 2009. View Article : Google Scholar : PubMed/NCBI

49 

Dinner S and Platanias LC: Targeting the mTOR pathway in Leukemia. J Cell Biochem. 117:1745–1752. 2016. View Article : Google Scholar : PubMed/NCBI

50 

Eaves CJ and Humphries RK: Acute myeloid leukemia and the Wnt pathway. N Engl J Med. 362:2326–2327. 2010. View Article : Google Scholar : PubMed/NCBI

51 

Malik MF Arshad: Influence of microvesicles in breast cancer metastasis and their therapeutic implications. Arch Iran Med. 18:189–192. 2015.PubMed/NCBI

52 

Antonyak MA and Cerione RA: Microvesicles as mediators of intercellular communication in cancer. Methods Mol Biol. 1165:147–173. 2014. View Article : Google Scholar : PubMed/NCBI

53 

Jorfi S and Inal JM: The role of microvesicles in cancer progression and drug resistance. Biochem Soc Trans. 41:293–298. 2013. View Article : Google Scholar : PubMed/NCBI

54 

Wang Y, Cheng Q, Liu J and Dong M: Leukemia Stem Cell-Released Microvesicles Promote the Survival and Migration of Myeloid Leukemia Cells and These Effects Can Be Inhibited by MicroRNA34a Overexpression. Stem Cell Int. 2016:93134252016.

55 

Lu L, Chen XM, Tao HM, Xiong W, Jie SH and Li HY: Regulation of the expression of zinc finger protein genes by microRNAs enriched within acute lymphoblastic leukemia-derived microvesicles. Genet Mol Res. 14:11884–11895. 2015. View Article : Google Scholar : PubMed/NCBI

56 

Ghosh AK, Secreto CR, Knox TR, Ding W, Mukhopadhyay D and Kay NE: Circulating microvesicles in B-cell chronic lymphocytic leukemia can stimulate marrow stromal cells: Implications for disease progression. Blood. 115:1755–1764. 2010. View Article : Google Scholar : PubMed/NCBI

57 

van der Vos KE, Balaj L, Skog J and Breakefield XO: Brain tumor microvesicles: insights into intercellular communication in the nervous system. Cell Mol Neurobiol. 31:949–959. 2011. View Article : Google Scholar : PubMed/NCBI

58 

Redig AJ, Vakana E and Platanias LC: Regulation of mammalian target of rapamycin and mitogen activated protein kinase pathways by BCR-ABL. Leuk Lymphoma. 52:(Suppl 1). S45–S53. 2011. View Article : Google Scholar

59 

Liang T, Yu J, Liu C and Guo L: An exploration of evolution, maturation, expression and function relationships in mir-23 ~27 ~24 cluster. PLoS One. 9:e1062232014. View Article : Google Scholar : PubMed/NCBI

60 

Yan J, Ma S, Zhang Y, Yin C, Zhou X and Zhang G: Potential role of microRNA-126 in the diagnosis of cancers: A systematic review and meta-analysis. Medicine (Baltimore). 95:e46442016. View Article : Google Scholar : PubMed/NCBI

61 

Xiao J, Lin HY, Zhu YY, Zhu YP and Chen LW: MiR-126 regulates proliferation and invasion in the bladder cancer BLS cell line by targeting the PIK3R2-mediated PI3K/Akt signaling pathway. Onco Targets Ther. 9:5181–5193. 2016. View Article : Google Scholar : PubMed/NCBI

62 

Grady B, Goharderakhshan R, Chang J, Ribeiro-Filho LA, Perinchery G, Franks J, Presti J, Carroll P and Dahiya R: Frequently deleted loci on chromosome 9 may harbor several tumor suppressor genes in human renal cell carcinoma. J Urol. 166:1088–1092. 2001. View Article : Google Scholar : PubMed/NCBI

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Chen X, Xiong W and Li H: Comparison of microRNA expression profiles in K562-cells-derived microvesicles and parental cells, and analysis of their roles in leukemia. Oncol Lett 12: 4937-4948, 2016.
APA
Chen, X., Xiong, W., & Li, H. (2016). Comparison of microRNA expression profiles in K562-cells-derived microvesicles and parental cells, and analysis of their roles in leukemia. Oncology Letters, 12, 4937-4948. https://doi.org/10.3892/ol.2016.5308
MLA
Chen, X., Xiong, W., Li, H."Comparison of microRNA expression profiles in K562-cells-derived microvesicles and parental cells, and analysis of their roles in leukemia". Oncology Letters 12.6 (2016): 4937-4948.
Chicago
Chen, X., Xiong, W., Li, H."Comparison of microRNA expression profiles in K562-cells-derived microvesicles and parental cells, and analysis of their roles in leukemia". Oncology Letters 12, no. 6 (2016): 4937-4948. https://doi.org/10.3892/ol.2016.5308
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Spandidos Publications style
Chen X, Xiong W and Li H: Comparison of microRNA expression profiles in K562-cells-derived microvesicles and parental cells, and analysis of their roles in leukemia. Oncol Lett 12: 4937-4948, 2016.
APA
Chen, X., Xiong, W., & Li, H. (2016). Comparison of microRNA expression profiles in K562-cells-derived microvesicles and parental cells, and analysis of their roles in leukemia. Oncology Letters, 12, 4937-4948. https://doi.org/10.3892/ol.2016.5308
MLA
Chen, X., Xiong, W., Li, H."Comparison of microRNA expression profiles in K562-cells-derived microvesicles and parental cells, and analysis of their roles in leukemia". Oncology Letters 12.6 (2016): 4937-4948.
Chicago
Chen, X., Xiong, W., Li, H."Comparison of microRNA expression profiles in K562-cells-derived microvesicles and parental cells, and analysis of their roles in leukemia". Oncology Letters 12, no. 6 (2016): 4937-4948. https://doi.org/10.3892/ol.2016.5308
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