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Article

Pigment epithelium‑derived factor has a role in the progression of papillary thyroid carcinoma by affecting the HIF1α‑VEGF signaling pathway

  • Authors:
    • Yichen Lv
    • Yu Sun
    • Tiefeng Shi
    • Chenlei Shi
    • Huadong Qin
    • Zhaozhu Li
  • View Affiliations / Copyright

    Affiliations: The Fourth Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China, Department of Pediatric Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China
  • Pages: 5217-5222
    |
    Published online on: October 25, 2016
       https://doi.org/10.3892/ol.2016.5316
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Abstract

The progression mechanism of papillary thyroid carcinoma (PTC) remains largely unknown. Accumulating evidence has suggested that various targets of pigment epithelium‑derived factor (PEDF) are able to inhibit cancer progression. The aim of the present study was to examine PEDF expression in PTC patients and to investigate its relationship with aggressive clinicopathological features, as well as to explore whether PEDF affects the progression of PTC via the hypoxia‑inducible factor 1α (HIF1α)‑vascular endothelial growth factor (VEGF) pathway. A total of 271 patients with PTC, including 24 men and 247 women, were enrolled in the present study. Relevant patient data, including demographic features, preoperative clinical features and pathological features, were collected for analysis. The protein expression levels of PEDF in PTC tissues were detected using immunohistochemical staining, and the mRNA expression levels of PEDF, VEGF and HIF1α in 15 PTC tissues with lymph node metastasis (LNM) and 10 tissues without LNM were detected using reverse transcription‑quantitative polymerase chain reaction. Immunohistochemical staining with an anti‑PEDF antibody detected PEDF expression in 74.5% of the PTC tissues. PEDF expression levels were significantly correlated with LNM, extrathyroid invasion, a high TNM stage, the presence of the BRAFV600E mutation and tumor size. PEDF mRNA expression levels were significantly decreased in PTC tissues with LNM, as compared with PTC tissues without LNM, while the mRNA expression levels of HIF1α and VEGF were markedly increased in PTC tissues with LNM. Taken together, the results of the present study suggested that PEDF plays a role in the progression of PTC, and that PEDF may exert an anti‑angiogenesis role by affecting the HIF1α‑VEGF pathway, eventually inhibiting the metastasis of PTC.
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Copy and paste a formatted citation
Spandidos Publications style
Lv Y, Sun Y, Shi T, Shi C, Qin H and Li Z: Pigment epithelium‑derived factor has a role in the progression of papillary thyroid carcinoma by affecting the HIF1α‑VEGF signaling pathway. Oncol Lett 12: 5217-5222, 2016.
APA
Lv, Y., Sun, Y., Shi, T., Shi, C., Qin, H., & Li, Z. (2016). Pigment epithelium‑derived factor has a role in the progression of papillary thyroid carcinoma by affecting the HIF1α‑VEGF signaling pathway. Oncology Letters, 12, 5217-5222. https://doi.org/10.3892/ol.2016.5316
MLA
Lv, Y., Sun, Y., Shi, T., Shi, C., Qin, H., Li, Z."Pigment epithelium‑derived factor has a role in the progression of papillary thyroid carcinoma by affecting the HIF1α‑VEGF signaling pathway". Oncology Letters 12.6 (2016): 5217-5222.
Chicago
Lv, Y., Sun, Y., Shi, T., Shi, C., Qin, H., Li, Z."Pigment epithelium‑derived factor has a role in the progression of papillary thyroid carcinoma by affecting the HIF1α‑VEGF signaling pathway". Oncology Letters 12, no. 6 (2016): 5217-5222. https://doi.org/10.3892/ol.2016.5316
Copy and paste a formatted citation
x
Spandidos Publications style
Lv Y, Sun Y, Shi T, Shi C, Qin H and Li Z: Pigment epithelium‑derived factor has a role in the progression of papillary thyroid carcinoma by affecting the HIF1α‑VEGF signaling pathway. Oncol Lett 12: 5217-5222, 2016.
APA
Lv, Y., Sun, Y., Shi, T., Shi, C., Qin, H., & Li, Z. (2016). Pigment epithelium‑derived factor has a role in the progression of papillary thyroid carcinoma by affecting the HIF1α‑VEGF signaling pathway. Oncology Letters, 12, 5217-5222. https://doi.org/10.3892/ol.2016.5316
MLA
Lv, Y., Sun, Y., Shi, T., Shi, C., Qin, H., Li, Z."Pigment epithelium‑derived factor has a role in the progression of papillary thyroid carcinoma by affecting the HIF1α‑VEGF signaling pathway". Oncology Letters 12.6 (2016): 5217-5222.
Chicago
Lv, Y., Sun, Y., Shi, T., Shi, C., Qin, H., Li, Z."Pigment epithelium‑derived factor has a role in the progression of papillary thyroid carcinoma by affecting the HIF1α‑VEGF signaling pathway". Oncology Letters 12, no. 6 (2016): 5217-5222. https://doi.org/10.3892/ol.2016.5316
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