Milia may originate from the outermost layers of the hair bulge of the outer root sheath: A case report

Kurokawa,Ichiro; Kakuno,Ayako; Tsubura,Airo

doi:10.3892/ol.2016.5335

December-2016 Volume 12 Issue 6

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December-2016 Volume 12 Issue 6

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Case Report

Milia may originate from the outermost layers of the hair bulge of the outer root sheath: A case report

Authors:
- Ichiro Kurokawa
- Ayako Kakuno
- Airo Tsubura
View Affiliations / Copyright

Affiliations: Department of Dermatology, Acne Clinical Research Center, Meiwa Hospital, Nishinomiya, Hyōgo 663‑8186, Japan, Department of Pathology, Meiwa Hospital, Nishinomiya, Hyōgo 663‑8186, Japan, Department of Pathology, Kansai Medical University, Moriguchi, Osaka 570‑8506, Japan
Pages: 5190-5192
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Published online on: November 2, 2016

https://doi.org/10.3892/ol.2016.5335
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Abstract

It has been hypothesized that milia originate from the hair bulge of the outer root sheath. To elucidate the histogenesis of milia, an immunohistochemical study was performed using anti‑keratin and anti‑filaggrin antibodies to determine the levels of keratin and filaggrin expression. Keratin expression was evaluated using anti‑keratin antibodies against K1, K7, K8, K10, K14, K15, K16, K17, K18, K19 and K20. K1 and K10 expression were detected in the suprabasal layers of the more superficial section of the cyst walls, but not in the deeper section of the cyst walls. However, K14 and K17 were expressed in all layers of the cyst walls. Notably, K15 was expressed in the outermost layer of the deeper section of the cyst walls and hair germ structure, whereas filaggrin was expressed in the superficial layer of the more superficial section of the cyst walls. Therefore, the pattern of keratin and filaggrin expression indicates that milia may originate from the outermost cells of the hair bulge of the outer root sheath.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Milia may originate from the outermost layers of the hair bulge of the outer root sheath: A case report

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