Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
December-2016 Volume 12 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2016 Volume 12 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Protective effect of selenium against cisplatin-induced nasopharyngeal cancer in male albino rats

  • Authors:
    • Kan Zhu
    • Lei Jiang
    • Yun Chu
    • Yong‑Sheng Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Otorhinolaryngology, Wuxi No. 2 People's Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu 214002, P.R. China, Department of Neurosurgery, Wuxi No. 2 People's Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu 214002, P.R. China, Department of Surgery, Wuxi No. 2 People's Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu 214002, P.R. China
    Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5068-5074
    |
    Published online on: November 2, 2016
       https://doi.org/10.3892/ol.2016.5346
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study evaluated the protective effect of selenium against cisplatin-induced nasopharyngeal cancer in the cardiac tissue of adult rats. Male Wistar rats were divided into 4 groups of 6 rats each. Different combinations of selenium and cisplatin were administered for 45 days, following which the animals were sacrificed and the nasopharyngeal tissue was surgically removed. Lipid peroxidation, reduced glutathione, and the antioxidant enzymes superoxide dismutase (SOD), catalase and lactate dehydrogenase (LDH) were measured. Apoptotic‑related gene (p53, bax and caspase 3) mRNA expression was determined using quantitative polymerase chain reaction. Caspase 3 activity was also measured in all the groups. The results demonstrated that selenium significantly reduced the levels of malondialdehyde. The levels of glutathione, SOD, LDH and catalase significantly increased following selenium treatment. Relative mRNA expression (p53, bax and caspase 3) was significantly reduced in the cisplatin-treated rats, but it significantly increased following selenium treatment. The anticancer activity of selenium was also investigated in HK1cells. Fluorescence and confocal microscopy were used to analyze apoptosis and reactive oxygen species. The protective effect of selenium was also evident through caspase 3 activity, which significantly increased following selenium treatment. Taken together, these results indicate that selenium may be beneficial against cisplatin-induced nasopharyngeal cancer.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

Figure 10

View References

1 

Tinggi U: Selenium: Its role as an antioxidant in human health. Environ Health Prev Med. 13:102–108. 2008. View Article : Google Scholar : PubMed/NCBI

2 

El-Demerdash FM and Nasr HM: Antioxidant effect of selenium on lipid peroxidation, hyperlipidemia and biochemical parameters in rats exposed to diazinon. J Trace Elem Med Biol. 28:89–93. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Tinggi U, Reilly C and Patterson CM: Determination of selenium in foodstuffs using spectrofluorometry and hydride generation atomic absorption spectrometry. J Food Comp Anal. 5:269–280. 1992. View Article : Google Scholar

4 

Rayman M: Selenium and human health. Lancet. 379:1256–1268. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Brigelius-Flohé R, Banning A and Schnurr K: Selenium- dependent enzymes in endothelial cell function. Antioxid Redox Signal. 5:205–215. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Loehrer PJ and Einhorn LH: Drugs five years later. Cisplatin. Ann Intern Med. 100:704–713. 1984. View Article : Google Scholar : PubMed/NCBI

7 

Pandurangan M, Veerappan M and Kim DH: Cytotoxicity of zinc oxide nanoparticles on antioxidant enzyme activities and mRNA expression in the cocultured C2C12 and 3T3-L1 cells. Appl Biochem Biotechnol. 175:1270–1280. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Muthuraman P, Ramkumar K and Kim DH: Analysis of the dose-dependent effect of zinc oxide nanoparticles on the oxidative stress and antioxidant enzyme activity in adipocytes. Appl Biochem Biotechnol. 174:2851–2863. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Muthuraman P: Effect of cortisol on caspases in the co-cultured C2C12 and 3T3-L1 cells. Appl Biochem Biotechnol. 173:980–988. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Muthuraman P, Kim DH, Muthuviveganandavel V, Vikramathithan J and Ravikumar S: Differential bio-potential of ZnS nanoparticles to normal MDCK cells and cervical carcinoma HeLa cells. J Nanosci Nanotechnol. 15:1–8. 2015.PubMed/NCBI

11 

Milosavljevic N, Duranton C, Djerbi N, Puech PH, Gounon P, Lagadic-Gossmann D, Dimanche-Boitrel MT, Rauch C, Tauc M, Counillon L and Poët M: Nongenomic effects of cisplatin: Acute inhibition of mechanosensitive transporters and channels without actin remodeling. Cancer Res. 70:7514–7522. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Windsor RE, Strauss SJ, Kallis C, Wood NE and Whelan JS: Germline genetic polymorphisms may influence chemotherapy response and disease outcome in osteosarcoma: A pilot study. Cancer. 118:1856–1867. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Farber JL, Kyle ME and Coleman JB: Mechanisms of cell injury by activated oxygen species. La Inves. 62:670–679. 1990.

14 

Gan L, Liu Q, Xu HB, Zhu YS and Yang XL: Effects of selenium overexposure on glutathione peroxidase and thioredoxin reductase gene expressions and activities. Biol Trace Elem Res. 89:165–175. 2002. View Article : Google Scholar : PubMed/NCBI

15 

Halliwell B and Gutteridge JMC: Oxidative stress: Adaptation, damage, repair and deathFree Radicals in Biology and Medicine. 3rd. Oxford University Press; Oxford: pp. 246–350. 2001

16 

Yuan X and Tang C: Lead effect on DNA and albumin in chicken blood and the protection of selenium nutrition. J Environ Sci Health A. 34:1875–1887. 1999. View Article : Google Scholar

17 

Scott D, Galloway SM, Marshall RR, Ishidate M Jr, Brusick D, Ashby J and Myhr BC: International commission for the protection against environment mutagens and carcinogens. Genotoxicity under extreme culture conditions. A report from ICPEMC task Group 9. Mutat Res. 257:147–205. 1991. View Article : Google Scholar : PubMed/NCBI

18 

Cavalcantea DG, Martinez CB and Sofiaa SH: Genotoxic effects of Roundup on the fish Prochilodus lineatus. Mutat Res. 655:41–46. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Eder E, Wacker M, Lutz U, Nair J, Fang X, Bartsch H, Beland FA, Schlatter J and Lutz WK: Oxidative stress-related DNA adducts in the liver of female rats fed with sunflowers, rapeseed-, olive- or coconut oil supplemented diets. Chem Biol Interact. 159:81–89. 2006. View Article : Google Scholar : PubMed/NCBI

20 

El-Bayoumy K: The protective role of selenium on genetic damage and on cancer. Mutat Res. 475:123–139. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Kara H, Cevik A, Konar V, Dayangac A and Yilmaz M: Protective effects of antioxidants against cadmium-induced oxidative damage in rat testes. Biol Trace Elem Res. 120:205–211. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Priscilla DH and Prince PS: Cardioprotective effect of gallic acid on cardiac troponin-T, cardiac marker enzymes, lipid peroxidation products and antioxidants in experimentally induced myocardial infarction in Wistar rats. Chem Biol Interact. 179:118–124. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Townsend DM, Tew KD and Tapiero H: The importance of glutathione in human disease. Biomed Pharmacother. 57:144–155. 2003. View Article : Google Scholar

24 

Hill MF and Singal PK: Right and left myocardial antioxidant responses during heart failure subsequent to myocardial infarction. Circulation. 96:2414–2420. 1997. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhu K, Jiang L, Chu Y and Zhang YS: Protective effect of selenium against cisplatin-induced nasopharyngeal cancer in male albino rats. Oncol Lett 12: 5068-5074, 2016.
APA
Zhu, K., Jiang, L., Chu, Y., & Zhang, Y. (2016). Protective effect of selenium against cisplatin-induced nasopharyngeal cancer in male albino rats. Oncology Letters, 12, 5068-5074. https://doi.org/10.3892/ol.2016.5346
MLA
Zhu, K., Jiang, L., Chu, Y., Zhang, Y."Protective effect of selenium against cisplatin-induced nasopharyngeal cancer in male albino rats". Oncology Letters 12.6 (2016): 5068-5074.
Chicago
Zhu, K., Jiang, L., Chu, Y., Zhang, Y."Protective effect of selenium against cisplatin-induced nasopharyngeal cancer in male albino rats". Oncology Letters 12, no. 6 (2016): 5068-5074. https://doi.org/10.3892/ol.2016.5346
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu K, Jiang L, Chu Y and Zhang YS: Protective effect of selenium against cisplatin-induced nasopharyngeal cancer in male albino rats. Oncol Lett 12: 5068-5074, 2016.
APA
Zhu, K., Jiang, L., Chu, Y., & Zhang, Y. (2016). Protective effect of selenium against cisplatin-induced nasopharyngeal cancer in male albino rats. Oncology Letters, 12, 5068-5074. https://doi.org/10.3892/ol.2016.5346
MLA
Zhu, K., Jiang, L., Chu, Y., Zhang, Y."Protective effect of selenium against cisplatin-induced nasopharyngeal cancer in male albino rats". Oncology Letters 12.6 (2016): 5068-5074.
Chicago
Zhu, K., Jiang, L., Chu, Y., Zhang, Y."Protective effect of selenium against cisplatin-induced nasopharyngeal cancer in male albino rats". Oncology Letters 12, no. 6 (2016): 5068-5074. https://doi.org/10.3892/ol.2016.5346
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team