|
1
|
Torre LA, Bray F, Siegel RL, Ferlay J,
Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA
Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Herszenyi L and Tulassay Z: Epidemiology
of gastrointestinal and liver tumors. Eur Rev Med Pharmacol Sci.
14:249–258. 2010.PubMed/NCBI
|
|
3
|
Deng GL, Zeng S and Shen H: Chemotherapy
and target therapy for hepatocellular carcinoma: New advances and
challenges. World J Hepatol. 7:787–798. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Mueller M, Hobiger S and Jungbauer A:
Anti-inflammatory activity of extracts from fruits, herbs and
spices. Food Chemistry. 122:987–996. 2010. View Article : Google Scholar
|
|
5
|
Liao W, Ning Z, Chen L, Wei Q, Yuan E,
Yang J and Ren J: Intracellular antioxidant detoxifying effects of
diosmetin on 2,2-azobis (2-amidinopropane) dihydrochloride
(AAPH)-induced oxidative stress through inhibition of reactive
oxygen species generation. J Agric Food Chem. 62:8648–8654. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Ciolino HP, Wang TT and Yeh GC: Diosmin
and diosmetin are agonists of the aryl hydrocarbon receptor that
differentially affect cytochrome P450 1A1 activity. Cancer Res.
58:2754–2760. 1998.PubMed/NCBI
|
|
7
|
Androutsopoulos VP and Spandidos DA: The
flavonoids diosmetin and luteolin exert synergistic cytostatic
effects in human hepatoma HepG2 cells via CYP1A-catalyzed
metabolism, activation of JNK and ERK and P53/P21 upregulation. J
Nutr Biochem. 24:496–504. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Liu B, Shi Y, Peng W, Zhang Q, Liu J, Chen
N and Zhu R: Diosmetin induces apoptosis by upregulating p53 via
the TGF-β signal pathway in HepG2 hepatoma cells. Mol Med Rep.
14:159–164. 2016.PubMed/NCBI
|
|
9
|
Grego-Bessa J, Díez J and Pompa JL: Notch
and epithelial-mesenchyme transition in development and tumor
progression: another turn of the screw. Cell cycle. 3:716–719.
2004. View Article : Google Scholar
|
|
10
|
Gramantieri L, Giovannini C, Lanzi A,
Chieco P, Ravaioli M, Venturi A, Grazi GL and Bolondi L: Aberrant
Notch3 and Notch4 expression in human hepatocellular carcinoma.
Liver Int. 27:997–1007. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Giovannini C, Gramantieri L, Chieco P,
Minguzzi M, Lago F, Pianetti S, Ramazzotti E, Marcu KB and Bolondi
L: Selective ablation of Notch3 in HCC enhances doxorubicin's death
promoting effect by a p53 dependent mechanism. J Hepatol.
50:969–979. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Konishi J, Yi F, Chen X, Vo H, Carbone DP
and Dang TP: Notch3 cooperates with the EGFR pathway to modulate
apoptosis through the induction of bim. Oncogene. 29:589–596. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Hu L, Xue F, Shao M, Deng A and Wei G:
Aberrant expression of Notch3 predicts poor survival for
hepatocellular carcinomas. Biosci Trends. 7:152–156.
2013.PubMed/NCBI
|
|
14
|
Zhang Q, Lu C, Fang T, Wang Y, Hu W, Qiao
J, Liu B, Liu J, Chen N, Li M and Zhu R: Notch3 functions as a
regulator of cell self-renewal by interacting with the β-catenin
pathway in hepatocellular carcinoma. Oncotarget. 6:3669–3679. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Zhou L, Zhang N, Song W, You N, Li Q, Sun
W, Zhang Y, Wang D and Dou K: The significance of Notch1 compared
with Notch3 in high metastasis and poor overall survival in
hepatocellular carcinoma. PLoS One. 8:e573822013. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Giovannini C, Minguzzi M, Baglioni M,
Fornari F, Giannone F, Ravaioli M, Cescon M, Chieco P, Bolondi L
and Gramantieri L: Suppression of p53 by Notch3 is mediated by
Cyclin G1 and sustained by MDM2 and miR-221 axis in hepatocellular
carcinoma. Oncotarget. 5:10607–10620. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Giovannini C, Baglioni M, Toaldo M Baron,
Ventrucci C, D'Adamo S, Cipone M, Chieco P, Gramantieri L and
Bolondi L: Notch3 inhibition enhances sorafenib cytotoxic efficacy
by promoting GSK3b phosphorylation and p21 downregulation in
hepatocellular carcinoma. Oncotarget. 4:1618–1631. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Vacca A, Felli MP, Palermo R, Di Mario G,
Calce A, Di Giovine M, Frati L, Gulino A and Screpanti I: Notch3
and pre-TCR interaction unveils distinct NF-kappaB pathways in
T-cell development and leukemia. EMBO J. 25:1000–1008. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Ihekwaba AEC, Broomhead DS, Grimley RL,
Benson N and Kell DB: Sensitivity analysis of parameters
controlling oscillatory signalling in the NF-κB pathway: The roles
of IKK and IκBα. Syst Biol. 1:93–103. 2004. View Article : Google Scholar
|
|
20
|
Chen GG, Leung J, Liang NC, Li L, Wu K,
Chan UP, Leung BC, Li M, Du J, Deng YF, et al:
Ent-11alpha-hydroxy-15-oxo-kaur-16-en-19-oic-acid inhibits
hepatocellular carcinoma in vitro and in vivo via stabilizing IkBα.
Invest New Drugs. 30:2210–2218. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Cao Z, Fu B, Deng B, Zeng Y, Wan X and Qu
L: Overexpression of Chemokine (C-X-C) ligand 1 (CXCL1) associated
with tumor progression and poor prognosis in hepatocellular
carcinoma. Cancer Cell Int. 14:862014. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Sheng ML, Xu GL, Zhang CH, Jia WD, Ren WH,
Liu WB, Zhou T, Wang YC, Lu ZL, Liu WF, et al: Aberrant estrogen
receptor alpha expression correlates with hepatocellular carcinoma
metastasis and its mechanisms. Hepatogastroenterology. 61:146–150.
2014.PubMed/NCBI
|
|
23
|
Wu M, Stockley PG and Martin WJ II: An
improved western blotting technique effectively reduces background.
Electrophoresis. 23:2373–2376. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Beg AA and Baltimore D: An essential role
for NF-κB in preventing TNF-alpha-induced cell death. Science.
274:7821996. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Pikarsky E, Porat RM, Stein I, Abramovitch
R, Amit S, Kasem S, Gutkovich-Pyest E, Urieli-Shoval S, Galun E and
Ben-Neriah Y: NF-kappaB functions as a tumour promoter in
inflammation-associated cancer. Nature. 431:461–466. 2004.
View Article : Google Scholar : PubMed/NCBI
|
