Biomarkers for EMT and MET in breast cancer: An update (Review)

  • Authors:
    • Fei Liu
    • Li‑Na Gu
    • Bao‑En Shan
    • Cui‑Zhi Geng
    • Mei‑Xiang Sang
  • View Affiliations

  • Published online on: November 8, 2016     https://doi.org/10.3892/ol.2016.5369
  • Pages: 4869-4876
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Abstract

Metastasis and recurrence are the leading cause of mortality due to breast cancer, but the underlying mechanisms are still poorly understood. Understanding the breast cancer metastasis mechanism is important for early diagnosis and treatment of breast cancer. The seeding and growth of breast cancer cells at sites distinct from the primary tumor is a complex and multistage process. Recently, it has been reported that the epithelial-mesenchymal transition (EMT) and the mesenchymal-epithelial transition (MET) are the main mechanisms for breast cancer metastasis. During EMT, carcinoma cells shed their differentiated epithelial characteristics, including cell‑cell adhesion, polarity and lack of motility, and acquire mesenchymal traits, including motility and invasiveness. This review has summarized the studies of known EMT biomarkers in the context of breast cancer progression. These biomarkers include EMT‑related genes, proteins, microRNAs and kinases. In general, the findings of these studies suggest that EMT markers are associated with the invasion and metastasis of breast cancer. Further studies on the link between EMT markers and breast cancer will contribute to identify biomarkers for predicting early breast cancer metastasis as well as to provide new ideas for the treatment of breast cancer.
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December-2016
Volume 12 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Liu F, Gu LN, Shan BE, Geng CZ and Sang MX: Biomarkers for EMT and MET in breast cancer: An update (Review). Oncol Lett 12: 4869-4876, 2016
APA
Liu, F., Gu, L., Shan, B., Geng, C., & Sang, M. (2016). Biomarkers for EMT and MET in breast cancer: An update (Review). Oncology Letters, 12, 4869-4876. https://doi.org/10.3892/ol.2016.5369
MLA
Liu, F., Gu, L., Shan, B., Geng, C., Sang, M."Biomarkers for EMT and MET in breast cancer: An update (Review)". Oncology Letters 12.6 (2016): 4869-4876.
Chicago
Liu, F., Gu, L., Shan, B., Geng, C., Sang, M."Biomarkers for EMT and MET in breast cancer: An update (Review)". Oncology Letters 12, no. 6 (2016): 4869-4876. https://doi.org/10.3892/ol.2016.5369