Surgical treatment of solid hemangioblastomas of the posterior fossa: A report of 28 cases

Cui,Hua; Zou,Jian; Bao,Ying‑Hui; Wang,Ming‑Sheng; Wang,Yong

doi:10.3892/ol.2016.5531

March-2017 Volume 13 Issue 3

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March-2017 Volume 13 Issue 3

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Surgical treatment of solid hemangioblastomas of the posterior fossa: A report of 28 cases

Authors:
- Hua Cui
- Jian Zou
- Ying‑Hui Bao
- Ming‑Sheng Wang
- Yong Wang
View Affiliations / Copyright

Affiliations: Department of Neurosurgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, P.R. China, Department of Clinical Laboratory Science, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu 214023, P.R. China

Copyright: © Cui et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 1125-1130
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Published online on: December 23, 2016

https://doi.org/10.3892/ol.2016.5531
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Abstract

This study evaluated the clinical features, treatment strategies and outcomes of solid hemangioblastomas in 28 patients diagnosed with hypervascular lesions in the posterior fossa. Preoperative embolization of the feeding arteries had limited effects, with only 7 patients benefitting from it for the reduction of intraoperative hemorrhage. The tumor was completely removed in all patients, and 22 patients had a full recovery, while 6 patients, all of whom had van Hippel Lindau disease, developed recurrences. The present study demonstrated that meticulous en bloc surgical resection was the optimal treatment for solid hemangioblastomas of the posterior fossa. For large tumors, preoperative embolization was critical for preventing postoperative morbidity. Given the improvements in microsurgical techniques and the understanding of the tumor vascular pattern, total tumor removal associated with a low mortality rate could be achieved.

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1	Amano T, Tokunaga S, Shono T, Mizoguchi M, Matsumoto K, Yoshida F and Sasaki T: Cerebellar haemangioblastoma manifesting as hearing disturbance. Neurol Med Chir (Tokyo). 49:418–420. 2009. View Article : Google Scholar : PubMed/NCBI
2	Rachinger J, Buslei R, Prell J and Strauss C and Strauss C: Solid haemangioblastomas of the CNS: A review of 17 consecutive cases. Neurosurg Rev. 32:37–47; discussion 47–48. 2009. View Article : Google Scholar : PubMed/NCBI
3	Roberti F, Jones RV and Wright DC: Cranial nerve haemangioblastomas. Report of a rare case and review of literature. Surg Neurol. 67:640–646; discussion 646. 2007. View Article : Google Scholar : PubMed/NCBI
4	Singounas EG: Haemangioblastomas of the central nervous system. Acta Neurochir (Wien). 44:107–113. 1978. View Article : Google Scholar : PubMed/NCBI
5	Kamitani H, Hirano N, Takigawa H, Yokota M, Miyata H, Ohama E and Watanabe T: Attenuation of vascularity by preoperative radiosurgery facilitates total removal of a hypervascular haemangioblastoma at the cerebello-pontine angle: Case report. Surg Neurol. 62:238–243; discussion 243–244. 2004. View Article : Google Scholar : PubMed/NCBI
6	Matsushima T, Kawashima M, Masuoka J, Mineta T and Inoue T: Transcondylar fossa (supracondylar transjugular tubercle) approach: Anatomic basis for the approach, surgical procedures, and surgical experience. Skull Base. 20:83–91. 2010. View Article : Google Scholar : PubMed/NCBI
7	Nair BR, Joseph V, Chacko G and Keshava SN: Giant solid haemangioblastoma of the cerebellopontine angle: A technically challenging case. Neurol India. 62:228–229. 2014. View Article : Google Scholar : PubMed/NCBI
8	Wan JQ, Cui H and Wang Y: Surgical management of large solid haemangioblastomas of the posterior fossa. J Clin Neurosci. 18:39–42. 2011. View Article : Google Scholar : PubMed/NCBI
9	Bush ML, Pritchett C, Packer M, RayChaudhury A and Jacob A: Haemangioblastoma of the cerebellopontine angle. Arch Otolaryngol Head Neck Surg. 136:734–738. 2010. View Article : Google Scholar : PubMed/NCBI
10	Biondi A, Ricciardi GK, Faillot T, Capelle L, Van Effenterre R and Chiras J: Haemangioblastomas of the lower spinal region: Report of four cases with preoperative embolization and review of the literature. AJNR Am J Neuroradiol. 26:936–945. 2005.PubMed/NCBI
11	Dow GR, Sim DW and O'Sullivan MG: Excision of large solid haemangioblastomas of the cerebellopontine angle by a skull base approach. Br J Neurosurg. 16:168–171. 2002. View Article : Google Scholar : PubMed/NCBI
12	Cornelius JF, SaintMaurice JP, Bresson D, George B and Houdart E: Hemorrhage after particle embolization of haemangioblastomas: Comparison of outcomes in spinal and cerebellar lesions. J Neurosurg. 106:994–998. 2007. View Article : Google Scholar : PubMed/NCBI
13	Montano N, Doglietto F, Pedicelli A, Albanese A, Lauretti L, Pallini R, Lauriola L, Fernandez E and Maira G: Embolization of haemangioblastomas. J Neurosurg. 108:1063–1064. 2008. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Surgical treatment of solid hemangioblastomas of the posterior fossa: A report of 28 cases

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