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Article

AMPD3 is associated with the malignant characteristics of gastrointestinal stromal tumors

  • Authors:
    • Meihong Wong
    • Kohei Funasaka
    • Tomohiko Obayashi
    • Ryoji Miyahara
    • Yoshiki Hirooka
    • Michinari Hamaguchi
    • Hidemi Goto
    • Takeshi Senga
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya 466‑8550, Japan, Division of Cancer Biology, Nagoya University Graduate School of Medicine, Nagoya 466‑8550, Japan
  • Pages: 1281-1287
    |
    Published online on: December 23, 2016
       https://doi.org/10.3892/ol.2016.5532
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Abstract

Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors of the gastrointestinal tract. It is well known that activating mutations in the receptor tyrosine kinases KIT and platelet-derived growth factor receptor-α have essential roles in the pathogenesis of GISTs. The activation of these receptor protein kinases triggers multiple signaling pathways that promote cell proliferation and survival; however, the exact mechanism by which the activation of these kinases promotes the progression of GISTs remains uncertain. The aim of the present was to search for genes that are associated with the progression of GIST. The present study used reverse transcription-quantitative polymerase chain reaction to demonstrate that adenosine monophosphate deaminase 3 (AMPD3) was highly expressed in GISTs. Furthermore, transfection of GIST-T1 cells with KIT-specific small interfering RNA (siRNA) demonstrated that the expression of AMPD3 was dependent on KIT expression, while the depletion of AMPD3 in human GIST‑T1 cells using AMPD3-specific siRNA resulted in the suppression of cell migration and invasion. In addition, AMPD3 depletion sensitized GIST‑T1 cells to the tyrosine kinase inhibitor imatinib. The results of the present suggested that the combined inhibition of tyrosine kinases and AMPD3 may be effective for the treatment of GISTs.
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1 

Corless CL, Fletcher JA and Heinrich MC: Biology of gastrointestinal stromal tumors. J Clin Oncol. 22:3813–3825. 2004. View Article : Google Scholar : PubMed/NCBI

2 

Rubin BP, Singer S, Tsao C, Duensing A, Lux ML, Ruiz R, Hibbard MK, Chen CJ, Xiao S, Tuveson DA, et al: KIT activation is a ubiquitous feature of gastrointestinal stromal tumors. Cancer Res. 61:8118–8121. 2001.PubMed/NCBI

3 

Corless CL and Heinrich MC: Molecular pathobiology of gastrointestinal stromal sarcomas. Annu Rev Pathol. 3:557–586. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Corless CL, Barnett CM and Heinrich MC: Gastrointestinal stromal tumours: Origin and molecular oncology. Nat Rev Cancer. 11:865–878. 2011.PubMed/NCBI

5 

Duensing A, Medeiros F, McConarty B, Joseph NE, Panigrahy D, Singer S, Fletcher CD, Demetri GD and Fletcher JA: Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs). Oncogene. 23:3999–4006. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Heinrich MC, Corless CL, Demetri GD, Blanke CD, von Mehren M, Joensuu H, McGreevey LS, Chen CJ, Van den Abbeele AD, Druker BJ, et al: Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor. J Clin Oncol. 21:4342–4349. 2003. View Article : Google Scholar : PubMed/NCBI

7 

Morisaki T, Sabina RL and Holmes EW: Adenylate deaminase. A multigene family in humans and rats. J Biol Chem. 265:11482–11486. 1990.PubMed/NCBI

8 

Mahnke DK and Sabina RL: Calcium activates erythrocyte AMP deaminase [isoform E (AMPD3)] through a protein-protein interaction between calmodulin and the N-terminal domain of the AMPD3 polypeptide. Biochemistry. 44:5551–5559. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Mahnke-Zizelman DK and Sabina RL: Cloning of human AMP deaminase isoform E cDNAs. Evidence for a third AMPD gene exhibiting alternatively spliced 5′-exons. J Biol Chem. 267:20866–20877. 1992.PubMed/NCBI

10 

Coley W, Rayavarapu S, Pandey GS, Sabina RL, Van der Meulen JH, Ampong B, Wortmann RL, Rawat R and Nagaraju K: The molecular basis of skeletal muscle weakness in a mouse model of inflammatory myopathy. Arthritis Rheum. 64:3750–3759. 2012. View Article : Google Scholar : PubMed/NCBI

11 

van Adel BA and Tarnopolsky MA: Metabolic myopathies: Update 2009. J Clin Neuromuscul Dis. 10:97–121. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Akizu N, Cantagrel V, Schroth J, Cai N, Vaux K, McCloskey D, Naviaux RK, Van Vleet J, Fenstermaker AG, Silhavy JL, et al: AMPD2 regulates GTP synthesis and is mutated in a potentially treatable neurodegenerative brainstem disorder. Cell. 154:505–517. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Yamada Y, Goto H, Wakamatsu N and Ogasawara N: A rare case of complete human erythrocyte AMP deaminase deficiency due to two novel missense mutations in AMPD3. Hum Mutat. 17:782001. View Article : Google Scholar : PubMed/NCBI

14 

Cheng J, Morisaki H, Toyama K, Ikawa M, Okabe M and Morisaki T: AMPD3-deficient mice exhibit increased erythrocyte ATP levels but anemia not improved due to PK deficiency. Genes Cells. 17:913–922. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Desman G, Waintraub C and Zippin JH: Investigation of cAMP microdomains as a path to novel cancer diagnostics. Biochim Biophys Acta. 1842:2636–2645. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Fu QF, Liu Y, Fan Y, Hua SN, Qu HY, Dong SW, Li RL, Zhao MY, Zhen Y, Yu XL, et al: Alpha-enolase promotes cell glycolysis, growth, migration, and invasion in non-small cell lung cancer through FAK-mediated PI3K/AKT pathway. J Hematol Oncol. 8:222015. View Article : Google Scholar : PubMed/NCBI

17 

Pantano F, Santoni M, Procopio G, Rizzo M, Iacovelli R, Porta C, Conti A, Lugini A, Milella M, Galli L, et al: The changes of lipid metabolism in advanced renal cell carcinoma patients treated with everolimus: A new pharmacodynamic marker? PLoS One. 10:e01204272015. View Article : Google Scholar : PubMed/NCBI

18 

Chen H, Wang JP, Santen RJ and Yue W: Adenosine monophosphate activated protein kinase (AMPK), a mediator of estradiol-induced apoptosis in long-term estrogen deprived breast cancer cells. Apoptosis. 20:821–830. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Shieh JM, Chen YC, Lin YC, Lin JN, Chen WC, Chen YY, Ho CT and Way TD: Demethoxycurcumin inhibits energy metabolic and oncogenic signaling pathways through AMPK activation in triple-negative breast cancer cells. J Agric Food Chem. 61:6366–6375. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Zhang J, Wang Y, Shang D, Yu F, Liu W, Zhang Y, Feng C, Wang Q, Xu Y, Liu Y, et al: Characterizing and optimizing human anticancer drug targets based on topological properties in the context of biological pathways. J Biomed Inform. 54:132–140. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Rhodes DR, Yu J, Shanker K, Deshpande N, Varambally R, Ghosh D, Barrette T, Pandey A and Chinnaiyan AM: ONCOMINE: A cancer microarray database and integrated data-mining platform. Neoplasia. 6:1–6. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Taguchi T, Sonobe H, Toyonaga S, Yamasaki I, Shuin T, Takano A, Araki K, Akimaru K and Yuri K: Conventional and molecular cytogenetic characterization of a new human cell line, GIST-T1, established from gastrointestinal stromal tumor. Lab Invest. 82:663–665. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Buleje J, Acosta Ó, Guevara-Fujita M, Enriquez Y, Taxa L, Machicado E, Lizaraso-Caparó F and Fujita R: Mutational profile of KIT and PDGFRA genes in gastrointestinal stromal tumors in Peruvian samples. Rev Esp Enferm Dig. 107:72–78. 2015.PubMed/NCBI

24 

Comandone A and Boglione A: The importance of mutational status in prognosis and therapy of GIST. Recenti Prog Med. 106:17–22. 2015.(In Italian). PubMed/NCBI

25 

Joensuu H, Rutkowski P, Nishida T, Steigen SE, Brabec P, Plank L, Nilsson B, Braconi C, Bordoni A, Magnusson MK, et al: KIT and PDGFRA mutations and the risk of GI stromal tumor recurrence. J Clin Oncol. 33:634–642. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Ran L, Sirota I, Cao Z, Murphy D, Chen Y, Shukla S, Xie Y, Kaufmann MC, Gao D, Zhu S, et al: Combined inhibition of MAP kinase and KIT signaling synergistically destabilizes ETV1 and suppresses GIST tumor growth. Cancer Discov. 5:304–315. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Zhang Y, Gu ML, Zhou XX, Ma H, Yao HP and Ji F: Altered expression of ETV1 and its contribution to tumorigenic phenotypes in gastrointestinal stromal tumors. Oncol Rep. 32:927–934. 2014.PubMed/NCBI

28 

Liang J, Wu YL, Chen BJ, Zhang W, Tanaka Y and Sugiyama H: The C-kit receptor-mediated signal transduction and tumor-related diseases. Int J Biol Sci. 9:435–443. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Liu K: Stem cell factor (SCF)-kit mediated phosphatidylinositol 3 (PI3) kinase signaling during mammalian oocyte growth and early follicular development. Front Biosci. 11:126–135. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Kim A, Im M and Ma JY: Ethanol extract of Remotiflori radix induces endoplasmic reticulum stress-mediated cell death through AMPK/mTOR signaling in human prostate cancer cells. Sci Rep. 5:83942015. View Article : Google Scholar : PubMed/NCBI

31 

Schuster S, Penke M, Gorski T, Gebhardt R, Weiss TS, Kiess W and Garten A: FK866-induced NAMPT inhibition activates AMPK and downregulates mTOR signaling in hepatocarcinoma cells. Biochem Biophys Res Commun. 458:334–340. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Popovics P, Frigo DE, Schally AV and Rick FG: Targeting the 5′-AMP-activated protein kinase and related metabolic pathways for the treatment of prostate cancer. Expert Opin Ther Targets. 19:617–632. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wong M, Funasaka K, Obayashi T, Miyahara R, Hirooka Y, Hamaguchi M, Goto H and Senga T: AMPD3 is associated with the malignant characteristics of gastrointestinal stromal tumors. Oncol Lett 13: 1281-1287, 2017.
APA
Wong, M., Funasaka, K., Obayashi, T., Miyahara, R., Hirooka, Y., Hamaguchi, M. ... Senga, T. (2017). AMPD3 is associated with the malignant characteristics of gastrointestinal stromal tumors. Oncology Letters, 13, 1281-1287. https://doi.org/10.3892/ol.2016.5532
MLA
Wong, M., Funasaka, K., Obayashi, T., Miyahara, R., Hirooka, Y., Hamaguchi, M., Goto, H., Senga, T."AMPD3 is associated with the malignant characteristics of gastrointestinal stromal tumors". Oncology Letters 13.3 (2017): 1281-1287.
Chicago
Wong, M., Funasaka, K., Obayashi, T., Miyahara, R., Hirooka, Y., Hamaguchi, M., Goto, H., Senga, T."AMPD3 is associated with the malignant characteristics of gastrointestinal stromal tumors". Oncology Letters 13, no. 3 (2017): 1281-1287. https://doi.org/10.3892/ol.2016.5532
Copy and paste a formatted citation
x
Spandidos Publications style
Wong M, Funasaka K, Obayashi T, Miyahara R, Hirooka Y, Hamaguchi M, Goto H and Senga T: AMPD3 is associated with the malignant characteristics of gastrointestinal stromal tumors. Oncol Lett 13: 1281-1287, 2017.
APA
Wong, M., Funasaka, K., Obayashi, T., Miyahara, R., Hirooka, Y., Hamaguchi, M. ... Senga, T. (2017). AMPD3 is associated with the malignant characteristics of gastrointestinal stromal tumors. Oncology Letters, 13, 1281-1287. https://doi.org/10.3892/ol.2016.5532
MLA
Wong, M., Funasaka, K., Obayashi, T., Miyahara, R., Hirooka, Y., Hamaguchi, M., Goto, H., Senga, T."AMPD3 is associated with the malignant characteristics of gastrointestinal stromal tumors". Oncology Letters 13.3 (2017): 1281-1287.
Chicago
Wong, M., Funasaka, K., Obayashi, T., Miyahara, R., Hirooka, Y., Hamaguchi, M., Goto, H., Senga, T."AMPD3 is associated with the malignant characteristics of gastrointestinal stromal tumors". Oncology Letters 13, no. 3 (2017): 1281-1287. https://doi.org/10.3892/ol.2016.5532
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