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Article

Improving contrast enhancement in magnetic resonance imaging using 5-aminolevulinic acid‑induced protoporphyrin IX for high-grade gliomas

  • Authors:
    • Junkoh Yamamoto
    • Shingo Kakeda
    • Tetsuya Yoneda
    • Shun‑Ichiro Ogura
    • Shohei Shimajiri
    • Tohru Tanaka
    • Yukunori Korogi
    • Shigeru Nishizawa
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, University of Occupational and Environmental Health, Kitakyushu, Fukuoka 807‑8555, Japan, Department of Radiology, University of Occupational and Environmental Health, Kitakyushu, Fukuoka 807‑8555, Japan, Department of Medical Physics in Advanced Biomedical Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto 862‑0976, Japan, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama 226‑8501, Japan, Department of Surgical Pathology, University of Occupational and Environmental Health, Kitakyushu, Fukuoka 807‑8555, Japan, SBI Pharma Co., Ltd., Tokyo 106‑6019, Japan
  • Pages: 1269-1275
    |
    Published online on: December 27, 2016
       https://doi.org/10.3892/ol.2016.5539
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Abstract

Magnetic resonance imaging (MRI) with a gadolinium-based contrast agent is the gold standard for high-grade gliomas (HGGs). The compound 5‑aminolevulinic acid (5‑ALA) undergoes a high rate of cellular uptake, particularly in cancer cells. In addition, fluorescence‑guided resection with 5‑ALA is widely used for imaging HGGs. 5‑ALA is water soluble, while protoporphyrin IX (PpIX) is water insoluble. It was speculated whether converting from 5‑ALA to PpIX may relatively increase intracellular water content, and consequently, might enhance the T2 signal intensity in HGG. The aim of the present study was to assess whether 5‑ALA‑induced PpIX enhances the T2 signal intensity in patients with HGGs. A total of 4 patients who were candidates for HGG surgical treatment were prospectively analyzed with preoperative MRI. Patients received oral doses of 5‑ALA (20 mg/kg) 3 h prior to anesthesia. At 2.5 h post‑5‑ALA administration, T2‑weighted images (T2WIs) were obtained from all patients. Subsequently, tumors were evaluated via fluorescence using a modified operating microscope. Fluorescent tumor tissues were obtained to analyze the accumulation of 5-ALA-induced PpIX within the tumors, which was confirmed quantitatively by high‑performance liquid chromatography (HPLC) analysis. The MRI T2 signal intensity within the tumors was evaluated prior to and following 5-ALA administration. Three glioblastoma multiformes (GBMs) and 1 anaplastic oligodendroglioma (AO) were included in the analysis. Intraoperatively, all GBMs exhibited strong fluorescence of 5‑ALA‑induced PpIX, whilst no fluorescence was observed in the AO sample. HPLC analysis indicated a higher accumulation of 5‑ALA‑induced PpIX in the GBM samples compared with the AO sample. In total, 48 regions of interest were identified within the tumors from T2‑WIs. In the GBM group, the relative T2 signal intensity value within the tumors following 5‑ALA administration was significantly increased compared with the T2 signal intensity value prior to 5‑ALA administration (1.537±0.021 and 1.577±0.023, respectively; P=0.0055). No significant differences were observed in the AO group. These results suggest that the 5-ALA-induced PpIX enhanced the T2 signal intensity in HGG. Therefore, 5‑ALA may be a potentially useful MRI contrast reagent for HGG.
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1 

Shapiro WR, Green SB, Burger PC, Mahaley MS Jr, Selker RG, VanGilder JC, Robertson JT, Ransohoff J, Mealey J Jr and Strike TA: Randomized trial of three chemotherapy regimens and two radiotherapy regimens and two radiotherapy regimens in postoperative treatment of malignant glioma. Brain Tumor Cooperative Group Trial 8001. J Neurosurg. 71:1–9. 1989. View Article : Google Scholar : PubMed/NCBI

2 

Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, Belanger K, Brandes AA, Marosi C, Bogdahn U, et al: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 352:987–996. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Westphal M, Ram Z, Riddle V, Hilt D and Bortey E: Executive Committee of the Gliadel Study Group: Gliadel wafer in initial surgery for malignant glioma: Long-term follow-up of a multicenter controlled trial. Acta Neurochir (Wien). 148:269–275. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Lacroix M, AbiSaid D, Fourney DR, Gokaslan ZL, Shi W, DeMonte F, Lang FF, McCutcheon IE, Hassenbusch SJ, Holland E, et al: A multivariate analysis of 416 patients with glioblastoma multiforme: Prognosis, extent of resection and survival. J Neurosurg. 95:190–198. 2001. View Article : Google Scholar : PubMed/NCBI

5 

Sanai N, Polley MY, McDermott MW, Parsa AT and Berger MS: An extent of resection threshold for newly diagnosed glioblastomas. J Neurosurg. 115:3–8. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Laperriere N, Zuraw L and Cairncross G: Cancer Care Ontario Practice Guidelines Initiative Neuro-Oncology Disease Site Group: Radiotherapy for newly diagnosed malignant glioma in adults: A systematic review. Radiother Oncol. 64:259–273. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Wen PY, Macdonald DR, Reardon DA, Cloughesy TF, Sorensen AG, Galanis E, Degroot J, Wick W, Gilbert MR, Lassman AB, et al: Updated response assessment criteria for high-grade gliomas: Response assessment in neuro-oncology working group. J Clin Oncol. 28:1963–1972. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Coburger J, Engelke J, Scheuerle A, Thal DR, Hlavac M, Wirtz CR and König R: Tumor detection with 5-aminolevulinic acid fluorescence and Gd-DTPA-enhanced intraoperative MRI at the border of contrast-enhancing lesions: A prospective study based on histopathological assessment. Neurosurg Focus. 36:E32014. View Article : Google Scholar : PubMed/NCBI

9 

Claes A, Idema AJ and Wesseling P: Diffuse glioma growth: A guerilla war. Acta Neuropathol. 114:443–458. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Hutterer M, Hattingen E, Palm C, Proescholdt MA and Hau P: Current standards and new concepts in MRI and PET response assessment of antiangiogenic therapies in high-grade glioma patients. Neuro Oncol. 17:784–800. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Earnest F IV, Kelly PJ, Scheithauer BW, Kall BA, Cascino TL, Ehman RL, Forbes GS and Axley PL: Cerebral astrocytomas: Histopathologic correlation of MR and CT contrast enhancement with stereotactic biopsy. Radiology. 166:823–827. 1988. View Article : Google Scholar : PubMed/NCBI

12 

Wang Y, Alkasab TK, Narin O, Nazarian RM, Kaewlai R, Kay J and Abujudeh HH: Incidence of nephrogenic systemic fibrosis after adoption of restrictive gadolinium-based contrast agent guidelines. Radiology. 260:105–111. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Ishizuka M, Hagiya Y, Mizokami Y, Honda K, Tabata K, Kamachi T, Takahashi K, Abe F, Tanaka T, Nakajima M, et al: Porphyrins in urine after administration of 5-aminolevulinic acid as a potential tumor marker. Photodiagnosis Photodyn Ther. 8:328–331. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Yamamoto J, Yamamoto S, Hirano T, Li S, Koide M, Kohno E, Okada M, Inenaga C, Tokuyama T, Yokota N, et al: Monitoring of singlet oxygen is useful for predicting the photodynamic effects in the treatment for experimental glioma. Clin Cancer Res. 12:7132–7139. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Ishizuka M, Abe F, Sano Y, Takahashi K, Inoue K, Nakajima M, Kohda T, Komatsu N, Ogura S and Tanaka T: Novel development of 5-aminolevurinic acid (ALA) in cancer diagnoses and therapy. Int Immunopharmacol. 11:358–365. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Yamamoto J, Ogura S, Tanaka T, Kitagawa T, Nakano Y, Saito T, Takahashi M, Akiba D and Nishizawa S: Radiosensitizing effect of 5-aminolevulinic acid-induced protoporphyrin IX in glioma cells in vitro. Oncol Rep. 27:1748–1752. 2012.PubMed/NCBI

17 

Stummer W, Stocker S, Wagner S, Stepp H, Fritsch C, Goetz C, Goetz AE, Kiefmann R and Reulen HJ: Intraoperative detection of malignant gliomas by 5-aminolevulinic acid-induced porphyrin fluorescence. Neurosurgery. 42:518–526. 1998. View Article : Google Scholar : PubMed/NCBI

18 

Stummer W, Pichlmeier U, Meinel T, Wiestler OD, Zanella F and Reulen HJ: ALA-Glioma Study Group: Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: A randomised controlled multicentre phase III trial. Lancet Oncol. 7:392–401. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Junga CI, Yang JI, Park CH, Lee JB and Park HR: Formation of the Metal Complexes between Protoporphyrin IX and Divalent Metal Cations in the EnvironmentMolecular Environmental Soil Science at the Interfaces in the Earth's Critical Zone. Xu J and Huang PM: Springer Berlin Heidelberg; Berlin: pp. 97–99. 2010, View Article : Google Scholar

20 

Stummer W, Novotny A, Stepp H, Goetz C, Bise K and Reulen HJ: Fluorescence-guided resection of glioblastoma multiforme by using 5-aminolevulinic acid-induced porphyrins: A prospective study in 52 consecutive patients. J Neurosurg. 93:1003–1013. 2000. View Article : Google Scholar : PubMed/NCBI

21 

Yamamoto J, Ogura S, Shimajiri S, Nakano Y, Akiba D, Kitagawa T, Ueta K, Tanaka T and Nishizawa S: 5-aminolevulinic acid-induced protoporphyrin IX with multi-dose ionizing irradiation enhances host antitumor response and strongly inhibits tumor growth in experimental glioma in vivo. Mol Med Rep. 11:1813–1819. 2015.PubMed/NCBI

22 

Mlkvy P, Messmann H, Pauer M, Stewart JC, Millson CE, MacRobert AJ and Bown SG: Distribution and photodynamic effects of meso-tetrahydroxyphenylchlorin (mTHPC) in the pancreas and adjacent tissues in the Syrian golden hamster. Br J Cancer. 73:1473–1479. 1996. View Article : Google Scholar : PubMed/NCBI

23 

Yamamoto J, Kakeda S, Shimajiri S, Takahashi M, Watanabe K, Kai Y, Moriya J, Korogi Y and Nishizawa S: Tumor consistency of pituitary macroadenomas: Predictive analysis on the basis of imaging features with contrast-enhanced 3D FIESTA at 3T. AJNR Am J Neuroradiol. 35:297–303. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Pierallini A, Caramia F, Falcone C, Tinelli E, Paonessa A, Ciddio AB, Fiorelli M, Bianco F, Natalizi S, Ferrante L and Bozzao L: Pituitary macroadenomas: Preoperative evaluation of consistency with diffusion-weighted MR imaging-initial experience. Radiology. 239:223–231. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Watanabe K, Kakeda S, Yamamoto J, Ide S, Ohnari N, Nishizawa S and Korogi Y: Prediction of hard meningiomas: Quantitative evaluation based on the magnetic resonance signal intensity. Acta Radiol. 57:333–340. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW and Kleihues P: The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 114:97–109. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Kreisl TN, Kim L, Moore K, Duic P, Royce C, Stroud I, Garren N, Mackey M, Butman JA, Camphausen K, et al: Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma. J Clin Oncol. 27:740–745. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Hasselbalch B, Lassen U, Hansen S, Holmberg M, Sørensen M, Kosteljanetz M, Broholm H, Stockhausen MT and Poulsen HS: Cetuximab, bevacizumab, and irinotecan for patients with primary glioblastoma and progression after radiation therapy and temozolomide: A phase II trial. Neuro Oncol. 12:508–516. 2010.PubMed/NCBI

29 

Prados M, Cloughesy T, Samant M, Fang L, Wen PY, Mikkelsen T, Schiff D, Abrey LE, Yung WK, Paleologos N, et al: Response as a predictor of survival in patients with recurrent glioblastoma treated with bevacizumab. Neuro Oncol. 13:143–151. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Huang RY, Rahman R, Hamdan A, Kane C, Chen C, Norden AD, Reardon DA, Mukundun S and Wen PY: Recurrent glioblastoma: Volumetric assessment and stratification of patient survival with early posttreatment magnetic resonance imaging in patients treated with bevacizumab. Cancer. 119:3479–3488. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Henson JW, Ulmer S and Harris GJ: Brain tumor imaging in clinical trials. AJNR Am J Neuroradiol. 29:419–424. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Schmainda KM, Prah M, Connelly J, Rand SD, Hoffman RG, Mueller W and Malkin MG: Dynamic-susceptibility contrast agent MRI measures of relative cerebral blood volume predict response to bevacizumab in recurrent high-grade glioma. Neuro Oncol. 16:880–888. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Ellingson BM, Kim HJ, Woodworth DC, Pope WB, Cloughesy JN, Harris RJ, Lai A, Nghiemphu PL and Cloughesy TF: Recurrent glioblastoma treated with bevacizumab: Contrast-enhanced T1-weighted subtraction maps improve tumor delineation and aid prediction of survival in a multicenter clinical trial. Radiology. 271:200–210. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Dunet V, Rossier C, Buck A, Stupp R and Prior JO: Performance of 18F-fluoro-ethyl-tyrosine (18F-FET) PET for the differential diagnosis of primary brain tumor: A systematic review and Metaanalysis. J Nucl Med. 53:207–214. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Nihashi T, Dahabreh IJ and Terasawa T: PET in the clinical management of glioma: Evidence map. AJR Am J Roentgenol. 200:W654–W660. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Hutterer M, Nowosielski M, Putzer D, Jansen NL, Seiz M, Schocke M, McCoy M, Göbel G, la Fougère C, Virgolini IJ, et al: [18F]-fluoro-ethyl-L-tyrosine PET: A valuable diagnostic tool in neuro-oncology, but not all that glitters is glioma. Neuro Oncol. 15:341–351. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Galldiks N, Rapp M, Stoffels G, Fink GR, Shah NJ, Coenen HH, Sabel M and Langen KJ: Response assessment of bevacizumab in patients with recurrent malignant glioma using [18F]Fluoroethyl-L-tyrosine PET in comparison to MRI. Eur J Nucl Med Mol Imaging. 40:22–33. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Garcia SC, Moretti MB, Garay MV and Batlle A: Delta-aminolevulinic acid transport through blood-brain barrier. Gen Pharmacol. 31:579–582. 1998. View Article : Google Scholar : PubMed/NCBI

39 

Terr L and Weiner LP: An autoradiographic study of delta-aminolevulinic acid uptake by mouse brain. Exp Neurol. 79:564–568. 1983. View Article : Google Scholar : PubMed/NCBI

40 

McGillion FB, Thompson GG, Moore MR and Goldberg A: The passage of delta-aminolaevulinic acid across the blood-brain barrier of the rat: Effect of ethanol. Biochem Pharmacol. 23:472–474. 1974. View Article : Google Scholar : PubMed/NCBI

41 

Ennis SR, Novotny A, Xiang J, Shakui P, Masada T, Stummer W, Smith DE and Keep RF: Transport of 5-aminolevulinic acid between blood and brain. Brain Res. 959:226–234. 2003. View Article : Google Scholar : PubMed/NCBI

42 

Gibson SL, Havens JJ, Foster TH and Hilf R: Time-dependent intracellular accumulation of delta-aminolevulinic acid, induction of porphyrin synthesis and subsequent phototoxicity. Photochem Photobiol. 65:416–421. 1997. View Article : Google Scholar : PubMed/NCBI

43 

Stummer W, Reulen HJ, Novotny A, Stepp H and Tonn JC: Fluorescence-guided resections of malignant gliomas-an overview. Acta Neurochir Suppl. 88:9–12. 2003.PubMed/NCBI

44 

Samkoe KS, GibbsStrauss SL, Yang HH, Hekmatyar S Khan, Hoopes P Jack, O'Hara JA, Kauppinen RA and Pogue BW: Protoporphyrin IX fluorescence contrast in invasive glioblastomas is linearly correlated with Gd enhanced magnetic resonance image contrast but has higher diagnostic accuracy. J Biomed Opt. 16:0960082011. View Article : Google Scholar : PubMed/NCBI

45 

Wachter D, Kallenberg K, Wrede A, SchulzSchaeffer W, Behm T and Rohde V: Fluorescence-guided operation in recurrent glioblastoma multiforme treated with bevacizumab-fluorescence of the noncontrast enhancing tumor tissue? J Neurol Surg A Cent Eur Neurosurg. 73:401–406. 2012. View Article : Google Scholar : PubMed/NCBI

46 

Collaud S, Juzeniene A, Moan J and Lange N: On the selectivity of 5-aminolevulinic acid-induced protoporphyrin IX formation. Curr Med Chem Anticancer Agents. 4:301–316. 2004. View Article : Google Scholar : PubMed/NCBI

47 

Cho HR, Kim DH, Kim D, Doble P, Bishop D, Hare D, Park CK, Moon WK, Han MH and Choi SH: Malignant glioma: MR imaging by using 5-aminolevulinic acid in an animal model. Radiology. 272:720–730. 2014. View Article : Google Scholar : PubMed/NCBI

48 

Chavhan GB, Babyn PS, Thomas B, Shroff MM and Haacke EM: Principles, techniques, and applications of T2*-based MR imaging and its special applications. Radiographics. 29:1433–1449. 2009. View Article : Google Scholar : PubMed/NCBI

49 

Sugiyama Y, Hagiya Y, Nakajima M, Ishizuka M, Tanaka T and Ogura S: The heme precursor 5-aminolevulinic acid disrupts the Warburg effect in tumor cells and induces caspase-dependent apoptosis. Oncol Rep. 31:1282–1286. 2014.PubMed/NCBI

50 

Desideri A, Caccuri AM, Polizio F, Bastoni R and Federici G: Electron paramagnetic resonance identification of a highly reactive thiol group in the proximity of the catalytic site of human placenta glutathione transferase. J Biol Chem. 266:2063–2066. 1991.PubMed/NCBI

51 

Hiwatashi A, Kinoshita T, Moritani T, Wang HZ, Shrier DA, Numaguchi Y, Ekholm SE and Westesson PL: Hypointensity on diffusion-weighted MRI of the brain related to T2 shortening and susceptibility effects. AJR Am J Roentgenol. 181:1705–1709. 2003. View Article : Google Scholar : PubMed/NCBI

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Spandidos Publications style
Yamamoto J, Kakeda S, Yoneda T, Ogura SI, Shimajiri S, Tanaka T, Korogi Y and Nishizawa S: Improving contrast enhancement in magnetic resonance imaging using 5-aminolevulinic acid‑induced protoporphyrin IX for high-grade gliomas. Oncol Lett 13: 1269-1275, 2017.
APA
Yamamoto, J., Kakeda, S., Yoneda, T., Ogura, S., Shimajiri, S., Tanaka, T. ... Nishizawa, S. (2017). Improving contrast enhancement in magnetic resonance imaging using 5-aminolevulinic acid‑induced protoporphyrin IX for high-grade gliomas. Oncology Letters, 13, 1269-1275. https://doi.org/10.3892/ol.2016.5539
MLA
Yamamoto, J., Kakeda, S., Yoneda, T., Ogura, S., Shimajiri, S., Tanaka, T., Korogi, Y., Nishizawa, S."Improving contrast enhancement in magnetic resonance imaging using 5-aminolevulinic acid‑induced protoporphyrin IX for high-grade gliomas". Oncology Letters 13.3 (2017): 1269-1275.
Chicago
Yamamoto, J., Kakeda, S., Yoneda, T., Ogura, S., Shimajiri, S., Tanaka, T., Korogi, Y., Nishizawa, S."Improving contrast enhancement in magnetic resonance imaging using 5-aminolevulinic acid‑induced protoporphyrin IX for high-grade gliomas". Oncology Letters 13, no. 3 (2017): 1269-1275. https://doi.org/10.3892/ol.2016.5539
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Spandidos Publications style
Yamamoto J, Kakeda S, Yoneda T, Ogura SI, Shimajiri S, Tanaka T, Korogi Y and Nishizawa S: Improving contrast enhancement in magnetic resonance imaging using 5-aminolevulinic acid‑induced protoporphyrin IX for high-grade gliomas. Oncol Lett 13: 1269-1275, 2017.
APA
Yamamoto, J., Kakeda, S., Yoneda, T., Ogura, S., Shimajiri, S., Tanaka, T. ... Nishizawa, S. (2017). Improving contrast enhancement in magnetic resonance imaging using 5-aminolevulinic acid‑induced protoporphyrin IX for high-grade gliomas. Oncology Letters, 13, 1269-1275. https://doi.org/10.3892/ol.2016.5539
MLA
Yamamoto, J., Kakeda, S., Yoneda, T., Ogura, S., Shimajiri, S., Tanaka, T., Korogi, Y., Nishizawa, S."Improving contrast enhancement in magnetic resonance imaging using 5-aminolevulinic acid‑induced protoporphyrin IX for high-grade gliomas". Oncology Letters 13.3 (2017): 1269-1275.
Chicago
Yamamoto, J., Kakeda, S., Yoneda, T., Ogura, S., Shimajiri, S., Tanaka, T., Korogi, Y., Nishizawa, S."Improving contrast enhancement in magnetic resonance imaging using 5-aminolevulinic acid‑induced protoporphyrin IX for high-grade gliomas". Oncology Letters 13, no. 3 (2017): 1269-1275. https://doi.org/10.3892/ol.2016.5539
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