Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
March-2017 Volume 13 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2017 Volume 13 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Expression and clinical significance of YAP in laryngeal squamous cell carcinoma patients

  • Authors:
    • Shijie Qiu
    • Zhaoxia Xia
    • Qun Li
    • Dong Ye
    • Qi Huang
    • Zhisen Shen
  • View Affiliations / Copyright

    Affiliations: Department of Otorhinolaryngology (Head and Neck Surgery), Ningbo Medical Center Lihuili Hospital, Ningbo, Zhejiang 315040, P.R. China
  • Pages: 1311-1314
    |
    Published online on: December 27, 2016
       https://doi.org/10.3892/ol.2016.5541
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to investigate the expression levels of Yes-associated protein (YAP) in different grades of laryngeal squamous cell carcinoma (LSCC) tissues and vocal cord polyps tissues, and to investigate any correlations with clinical factors. The expression of YAP in 128 cases of LSCC and 10 cases of vocal cord polyps tissues was tested using immunohistochemistry. YAP was primarily present in the nucleus of LSCC and controls, whereas phosphorylated YAP expression was present in the cytoplasm. The results indicated that YAP expression was upregulated in LSCC samples compared with vocal cord polyps tissues. YAP expression was positively correlated with the malignant degree of LSCC (P<0.01) and a high level of YAP expression in LSCC tissues was correlated with pathological type, lymphatic metastasis and clinical stage. The present study provided evidence for the expression and localization of YAP in LSCC and vocal cord polyps tissues. Thus, YAP may be involved in the occurrence and development of LSCC as an oncogene.
View Figures

Figure 1

Figure 2

View References

1 

Guerrier Y and Dejean Y: Cancer of larynx and hypopharynx in women [M]UICC Manual of Clinical Oncology. 9. John Wiley & Sons, Ltd.; pp. 542–558. 2015

2 

Agra IM, Ferlito A, Takes RP, Silver CE, Olsen KD, Stoeckli SJ, Strojan P, Rodrigo JP, Gonçalves Filho J, Genden EM, et al: Diagnosis and treatment of recurrent laryngeal cancer following initial nonsurgical therapy. Head Neck. 34:727–735. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Saki N, Saki G, Abdoulhassan S, Rahim F, Mostofi NE and Soheila N: Effect of smoking tobacco in the etiology of cancer of larynx in Khuzestan. Jentashapir Journal of Health Research. 2:1–9. 2011.

4 

Xie ZN, Ji CY, Chen JC, Wang YN, Guan LQ, Li HT, Zhang M and Yang JH: The influence of pSilencer2.0-c-Met-siRNA on human cancer of larynx Hep-2 cells growth in nude mice. J Otolaryngol Ophthalmol Shandong Univ. 23:5–7. 2009.

5 

Tarnawski R, Skladowski K and Maciejewski B: Prognostic value of hemoglobin concentration in radiotherapy for cancer of supraglottic larynx. Int J Radiat Oncol Biol Phys. 38:1007–1011. 1997. View Article : Google Scholar : PubMed/NCBI

6 

Wynder EL, Bross IJ and Day E: A study of environmental factors in cancer of the larynx. Cancer. 9:86–110. 1956. View Article : Google Scholar : PubMed/NCBI

7 

Moore I: Intrinsic cancer of the larynx and the operation of Laryngo-Fissure, with a description of some new instruments specially designed for improving the technique. Multibody Syst Dyn. 31:191–240. 2013.

8 

Pan D: The hippo signaling pathway in development and cancer. Dev Cell. 19:491–505. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Cai J, Zhang N, Zheng Y, de Wilde RF, Maitra A and Pan D: The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program. Genes Dev. 24:2383–2388. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Ramos A and Camargo FD: The Hippo signaling pathway and stem cell biology. Trends Cell Biol. 22:339–346. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Mo JS, Park HW and Guan KL: The Hippo signaling pathway in stem cell biology and cancer. EMBO Rep. 15:642–656. 2014.PubMed/NCBI

12 

Yue T, Tian A and Jiang J: The cell adhesion molecule echinoid functions as a tumor suppressor and upstream regulator of the Hippo signaling pathway. Dev Cell. 22:255–267. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Kwon Y, Vinayagam A, Sun X, Dephoure N, Gygi SP, Hong P and Perrimon N: The Hippo signaling pathway interactome. Science. 342:737–740. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Gao PF, Cui PC, YanYan R, et al: Early vocal cords cancer and precancerosis of larynx treated with Nd: YAP laser under the laryngoscope and rigid endoscope. J Mod Oncol. 1:191–195. 2009.

15 

Li D, You HH, Jia YJ, Guo JD and Du HL: Association of C722T polymorphism in XRCC3 gene with larynx cancer: A meta-analysis. Tumor Biol. 35:5427–5430. 2014. View Article : Google Scholar

16 

Kim M, Kim M, Lee S, Kuninaka S, Saya H, Lee H, Lee S and Lim DS: cAMP/PKA signalling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes. EMBO J. 32:1543–1555. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Wang S, Li H, Wang G, Zhang T, Fu B, Ma M, Quan Z and Chen G: Yes-associated protein (YAP) expression is involved in epithelial-mesenchymal transition in hepatocellular carcinoma. Clin Transl Oncol. 18:172–177. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Hu X, Xin Y, Xiao Y and Zhao J: Overexpression of YAP1 is correlated with progression, metastasis and poor prognosis in patients with gastric carcinoma. Pathol Oncol Res. 20:805–811. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Chan SW, Lim CJ, Chong YF, Pobbati AV, Huang C and Hong W: Hippo pathway-independent restriction of TAZ and YAP by angiomotin. J Biol Chem. 286:7018–7026. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Gilgenkrantz H: The world according to YAP: A continuous cross-talk between Wnt and Hippo pathways. Med Sci (Paris). 29:868–874. 2013.(In French). View Article : Google Scholar : PubMed/NCBI

21 

Ma L: Abstract BS2-2: Targeting the LIFR-Hippo-YAP pathway as an anti-metastatic strategy. Cancer Res. 75:BS2-2. 2015. View Article : Google Scholar

22 

Chen D, Sun Y, Wei Y, Zhang P, Rezaeian AH, TeruyaFeldstein J, Gupta S, Liang H, Lin HK, Hung MC and Ma L: LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker. Nat Med. 18:1511–1517. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Hergovich A: YAP-Hippo signalling downstream of leukemia inhibitory factor receptor: Implications for breast cancer. Breast Cancer Res. 14:3262012. View Article : Google Scholar : PubMed/NCBI

24 

Li HX, He N and Zheng H: Research progress on correlation between YAP and tumor stem cells. Chin J Clin Oncol. 728–731. 2015.

25 

Bohl CR, Harihar S, Denning WL, Sharma R and Welch DR: Metastasis suppressors in breast cancers: Mechanistic insights and clinical potential. J Mol Med (Berl). 92:13–30. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Qiu S, Xia Z, Li Q, Ye D, Huang Q and Shen Z: Expression and clinical significance of YAP in laryngeal squamous cell carcinoma patients. Oncol Lett 13: 1311-1314, 2017.
APA
Qiu, S., Xia, Z., Li, Q., Ye, D., Huang, Q., & Shen, Z. (2017). Expression and clinical significance of YAP in laryngeal squamous cell carcinoma patients. Oncology Letters, 13, 1311-1314. https://doi.org/10.3892/ol.2016.5541
MLA
Qiu, S., Xia, Z., Li, Q., Ye, D., Huang, Q., Shen, Z."Expression and clinical significance of YAP in laryngeal squamous cell carcinoma patients". Oncology Letters 13.3 (2017): 1311-1314.
Chicago
Qiu, S., Xia, Z., Li, Q., Ye, D., Huang, Q., Shen, Z."Expression and clinical significance of YAP in laryngeal squamous cell carcinoma patients". Oncology Letters 13, no. 3 (2017): 1311-1314. https://doi.org/10.3892/ol.2016.5541
Copy and paste a formatted citation
x
Spandidos Publications style
Qiu S, Xia Z, Li Q, Ye D, Huang Q and Shen Z: Expression and clinical significance of YAP in laryngeal squamous cell carcinoma patients. Oncol Lett 13: 1311-1314, 2017.
APA
Qiu, S., Xia, Z., Li, Q., Ye, D., Huang, Q., & Shen, Z. (2017). Expression and clinical significance of YAP in laryngeal squamous cell carcinoma patients. Oncology Letters, 13, 1311-1314. https://doi.org/10.3892/ol.2016.5541
MLA
Qiu, S., Xia, Z., Li, Q., Ye, D., Huang, Q., Shen, Z."Expression and clinical significance of YAP in laryngeal squamous cell carcinoma patients". Oncology Letters 13.3 (2017): 1311-1314.
Chicago
Qiu, S., Xia, Z., Li, Q., Ye, D., Huang, Q., Shen, Z."Expression and clinical significance of YAP in laryngeal squamous cell carcinoma patients". Oncology Letters 13, no. 3 (2017): 1311-1314. https://doi.org/10.3892/ol.2016.5541
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team