Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
March-2017 Volume 13 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2017 Volume 13 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Transthyretin regulates the migration and invasion of JEG-3 cells

  • Authors:
    • Liyun Gong
    • Lei Zhu
    • Shuzhen Wang
    • Zhenyu Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Chao-Yang Hospital, Capital Medical University, Beijing 100020, P.R. China
    Copyright: © Gong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1242-1246
    |
    Published online on: December 28, 2016
       https://doi.org/10.3892/ol.2016.5545
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Preeclampsia (PE) is a pregnancy-specific disorder characterized by new-onset hypertension and proteinuria that occurs after 20 weeks of gestation. It involves several organs and continues to be a leading cause of maternal and perinatal morbidity and mortality worldwide. Shallow trophoblast invasion is a common pathological feature of PE. Transthyretin (TTR) is a 56-kDa homotetrameric protein that binds thyroid hormone and retinol binding protein. Dysregulated TTR expression has been found in cases of PE. The aim of the present study was to determine the functional role of TTR in the migration and invasion of JEG-3 choriocarcinoma cells. JEG-3 cells were transfected with a plasmid construct expressing TTR (pCMV-Myc-TTR) or an empty plasmid (pCMV-Myc). Cell migration and invasion capacities were assessed by Transwell migration and invasion assays, respectively. These experiments demonstrated that TTR overexpression significantly increased the migration and invasion potential of JEG-3 cells. Matrix metalloproteinases (MMPs) are a family of zinc-containing endopeptidases capable of degrading a wide range of extracellular matrix components. Western blot analysis revealed that TTR overexpression resulted in significantly increased levels of MMP2 and MMP9 in JEG-3 cells. In conclusion, our findings suggest an important role for TTR in regulating trophoblast invasion and migration, representing a possible underlying pathological and molecular mechanisms of PE.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

ACOG Committee on Obstetric Practice; American College of Obstetricians and Gynecologists, . ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002. Int J Gynaecol Obstet. 77:67–75. 2002.PubMed/NCBI

2 

Duley L, Meher S and Abalos E: Management of pre-eclampsia. BMJ. 332:463–468. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Poon LC and Nicolaides KH: Early prediction of preeclampsia. Obstet Gynecol Int. 2014:2973972014. View Article : Google Scholar : PubMed/NCBI

4 

Tal R: The role of hypoxia and hypoxia-inducible factor-1alpha in preeclampsia pathogenesis. Biol Reprod. 87:1342012. View Article : Google Scholar : PubMed/NCBI

5 

Goldman-Wohl D and Yagel S: Regulation of trophoblast invasion: from normal implantation to pre-eclampsia. Mol Cell Endocrinol. 187:233–238. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Lam C, Lim KH and Karumanchi SA: Circulating angiogenic factors in the pathogenesis and prediction of preeclampsia. Hypertension. 46:1077–1085. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Fruscalzo A, Schmitz R, Klockenbusch W, Köhler G, Londero AP, Siwetz M and Huppertz B: Human placental transthyretin in fetal growth restriction in combination with preeclampsia and the HELLP syndrome. Histochem Cell Biol. 138:925–932. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Chen Y and Zhang Z: Does transthyretin function as one of contributors for preeclampsia? Med Hypotheses. 76:8–10. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Huppertz B, Kertschanska S, Demir AY, Frank HG and Kaufmann P: Immunohistochemistry of matrix metalloproteinases (MMP), their substrates, and their inhibitors (TIMP) during trophoblast invasion in the human placenta. Cell Tissue Res. 291:133–148. 1998. View Article : Google Scholar : PubMed/NCBI

10 

Hannan NJ, Paiva P, Dimitriadis E and Salamonsen LA: Models for study of human embryo implantation: choice of cell lines? Biol Reprod. 82:235–245. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Harris LK: Review: trophoblast-vascular cell interactions in early pregnancy: how to remodel a vessel. Placenta. 31(Suppl): S93–S98. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Hiden U, Bilban M, Knöfler M and Desoye G: Kisspeptins and the placenta: regulation of trophoblast invasion. Rev Endocr Metab Disord. 8:31–39. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Pennington KA, Schlitt JM, Jackson DL, Schulz LC and Schust DJ: Preeclampsia: multiple approaches for a multifactorial disease. Dis Model Mech. 5:9–18. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Kaitu'u-Lino TJ, Ye L, Tuohey L, Dimitriadis E, Bulmer J, Rogers P, Menkhorst E, Van Sinderen M, Girling JE, Hannan N, et al: Corin, an enzyme with a putative role in spiral artery remodeling, is up-regulated in late secretory endometrium and first trimester decidua. Hum Reprod. 28:1172–1180. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Ren L, Liu YQ, Zhou WH and Zhang YZ: Trophoblast-derived chemokine CXCL12 promotes CXCR4 expression and invasion of human first-trimester decidual stromal cells. Hum Reprod. 27:366–374. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Kim YJ: Pathogenesis and promising non-invasive markers for preeclampsia. Obstet Gynecol Sci. 56:2–7. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Liu X, Dai LI and Zhou R: Association between preeclampsia and the CXC chemokine family (Review). Exp Ther Med. 9:1572–1576. 2015.PubMed/NCBI

18 

Gong LY, Zhang ZY, Zheng YH and Zhang JZ: Study of a serum protein fingerprint diagnostic model in patients with hypertensive disorder complicating pregnancy. Zhonghua Fu Chan Ke Za Zhi. 42:822–825. 2007.(In Chinese). PubMed/NCBI

19 

Liu C, Zhang N, Yu H, Chen Y, Liang Y, Deng H and Zhang Z: Proteomic analysis of human serum for finding pathogenic factors and potential biomarkers in preeclampsia. Placenta. 32:168–174. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Kalkunte SS, Neubeck S, Norris WE, Cheng SB, Kostadinov S, Vu Hoang D, Ahmed A, von Eggeling F, Shaikh Z, Padbury J, et al: Transthyretin is dysregulated in preeclampsia, and its native form prevents the onset of disease in a preclinical mouse model. Am J Pathol. 183:1425–1436. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Zhu L, Chen Y, Liu C, Deng H, Zhang N, Wang S and Zhang Z: Transthyretin as a novel candidate biomarker for preeclampsia. Exp Ther Med. 7:1332–1336. 2014.PubMed/NCBI

22 

Heissig B, Hattori K, Friedrich M, Rafii S and Werb Z: Angiogenesis: vascular remodeling of the extracellular matrix involves metalloproteinases. Curr Opin Hematol. 10:136–141. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Omran OM, Shokry M, Ismail H, Omar G and Rezk M: Expression of matrix metalloproteinases 2 and 9 in human trophoblasts of normal and preeclamptic placentas. Int J Health Sci (Qassim) 5 (Suppl 1). 21–23. 2011.

24 

Yang Y, Zhang J, Gong Y, Liu X, Bai Y, Xu W and Zhou R: Increased expression of prostasin contributes to early-onset severe preeclampsia through inhibiting trophoblast invasion. J Perinatol. 35:16–22. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Cockle JV, Gopichandran N, Walker JJ, Levene MI and Orsi NM: Matrix metalloproteinases and their tissue inhibitors in preterm perinatal complications. Reprod Sci. 14:629–645. 2007. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Gong L, Zhu L, Wang S and Zhang Z: Transthyretin regulates the migration and invasion of JEG-3 cells. Oncol Lett 13: 1242-1246, 2017.
APA
Gong, L., Zhu, L., Wang, S., & Zhang, Z. (2017). Transthyretin regulates the migration and invasion of JEG-3 cells. Oncology Letters, 13, 1242-1246. https://doi.org/10.3892/ol.2016.5545
MLA
Gong, L., Zhu, L., Wang, S., Zhang, Z."Transthyretin regulates the migration and invasion of JEG-3 cells". Oncology Letters 13.3 (2017): 1242-1246.
Chicago
Gong, L., Zhu, L., Wang, S., Zhang, Z."Transthyretin regulates the migration and invasion of JEG-3 cells". Oncology Letters 13, no. 3 (2017): 1242-1246. https://doi.org/10.3892/ol.2016.5545
Copy and paste a formatted citation
x
Spandidos Publications style
Gong L, Zhu L, Wang S and Zhang Z: Transthyretin regulates the migration and invasion of JEG-3 cells. Oncol Lett 13: 1242-1246, 2017.
APA
Gong, L., Zhu, L., Wang, S., & Zhang, Z. (2017). Transthyretin regulates the migration and invasion of JEG-3 cells. Oncology Letters, 13, 1242-1246. https://doi.org/10.3892/ol.2016.5545
MLA
Gong, L., Zhu, L., Wang, S., Zhang, Z."Transthyretin regulates the migration and invasion of JEG-3 cells". Oncology Letters 13.3 (2017): 1242-1246.
Chicago
Gong, L., Zhu, L., Wang, S., Zhang, Z."Transthyretin regulates the migration and invasion of JEG-3 cells". Oncology Letters 13, no. 3 (2017): 1242-1246. https://doi.org/10.3892/ol.2016.5545
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team