Intensity modulated radiation therapy to treat primary female mediastinal seminoma and massive pericardial effusion: A case report

Cao,Jun; Zhou,Yan; Zou,Fangwen; Ma,Jin‑An; Hu,Chunhong

doi:10.3892/ol.2017.5555

March-2017 Volume 13 Issue 3

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

March-2017 Volume 13 Issue 3

Full Size Image

Case Report

Intensity modulated radiation therapy to treat primary female mediastinal seminoma and massive pericardial effusion: A case report

Authors:
- Jun Cao
- Yan Zhou
- Fangwen Zou
- Jin‑An Ma
- Chunhong Hu
View Affiliations / Copyright

Affiliations: Department of Oncology, Hunan Cancer Hospital, Changsha, Hunan 410003, P.R. China, Department of Oncology, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, P.R. China
Pages: 1299-1302
|
Published online on: January 2, 2017

https://doi.org/10.3892/ol.2017.5555
Expand metrics +

Abstract

Primary mediastinal seminoma is a rare extragonadal germ cell tumour that mainly occurs in males. The present study reports the case of a 27‑year‑old woman that presented with superior vena cava syndrome and a large mass in the mediastinum, which was diagnosed as primary female mediastinal seminoma. The patient received 6 cycles of cisplatin‑based chemotherapy [4 cycles BEP chemotherapy (120 mg cisplatin, 0.45 g etoposide and 60 mg bleomycin, once every 3 weeks); 2 cycles IEP chemotherapy (120 mg cisplatin, 100 mg epirubicin and 6 g ifosfamide, once every 3 weeks)] and the patient showed an increase in the size of the mediastinal mass and hydropericardium, indicating a resistance to chemotherapy. Radiotherapy to the mediastinum (50 Gy over 18 fractions) and pericardium (30 Gy over 18 fractions) was performed. Following radiotherapy, the patient was considered to have a complete response to the treatment, and subsequent to a 5‑year follow‑up, no recurrence or metastasis was identified. To the best of our knowledge, no similar cases have been reported in the literature at present.

View Figures

View References

1	Hsu YJ, Pai L, Chen YC, Ho CL, Kao WY and Chao TY: Extragonadal germ cell tumors in Taiwan: An analysis of treatment results of 59 patients. Cancer. 95:766–774. 2002. View Article : Google Scholar : PubMed/NCBI
2	Wick MR, Perlman EJ, Orazi A, Müller-Hermelink HK, Zettl A, Göbel U, Bokemeyer C, Hartmann JT and Marx A: Germ cell tumors of the mediastinum. World Health Organization Classification of TumoursPathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart. Travis WD, Brambilla E, Müller-Hermelink HK and Harris CC: IARC Press; Lyon: pp. 198–219. 2004
3	Moran CA and Suster S: Primary germ cell tumors of the mediastinum: I. Analysis of 322 cases with special emphasis on teratomatous lesions and a proposal for histopathologic classification and clinical staging. Cancer. 80:681–690. 1997. View Article : Google Scholar : PubMed/NCBI
4	Schrader M, Kempkensteffen C, Christoph F, Hinz S, Weikert S, Lein M, Krause H, Stephan C, Jung K, Hoepfner M, et al: Germ cell tumors of the gonads: A selective review emphasizing problems in drug resistance and current therapy options. Oncology. 76:77–84. 2009. View Article : Google Scholar : PubMed/NCBI
5	Iwasa S, Ando M, Ono M, Hirata T, Yunokawa M, Nakano E, Yonemori K, Kouno T, Shimizu C, Tamura K, et al: Relapse with malignant transformation after chemotherapy for primary mediastinal seminoma: Case report. Jpn J Clin Oncol. 39:456–459. 2009. View Article : Google Scholar : PubMed/NCBI
6	Xu X, Sun C, Zhang L and Liang J: A case of mediastinal seminoma presenting as superior vena cava syndrome. Intern Med. 51:1269–1272. 2012. View Article : Google Scholar : PubMed/NCBI
7	Gilligan TD, Hayes DF, Seidenfeld J and Temin S: ASCO clinical practice guideline on uses of serum tumor markers in adult males with germ cell tumors. J Oncol Pract. 6:199–202. 2010. View Article : Google Scholar : PubMed/NCBI
8	Feldman DR, Patil S, Trinos MJ, Carousso M, Ginsberg MS, Sheinfeld J, Bajorin DF, Bosl GJ and Motzer RJ: Progression-free and overall survival in patients with relapsed/refractory germ cell tumors treated with single-agent chemotherapy: Endpoints for clinical trial design. Cancer. 118:981–986. 2012. View Article : Google Scholar : PubMed/NCBI
9	Liu TZ, Zhang DS, Liang Y, Zhou NN, Gao HF, Liu KJ and Wu HY: Treatment strategies and prognostic factors of patients with primary germ cell tumors in the mediastinum. J Cancer Res Clin Oncol. 137:1607–1612. 2011. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Intensity modulated radiation therapy to treat primary female mediastinal seminoma and massive pericardial effusion: A case report

This article is mentioned in:

Abstract

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Related Articles