Intensity modulated radiation therapy to treat primary female mediastinal seminoma and massive pericardial effusion: A case report
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- Published online on: January 2, 2017 https://doi.org/10.3892/ol.2017.5555
- Pages: 1299-1302
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Abstract
Primary mediastinal seminoma is a rare extragonadal germ cell tumour that mainly occurs in males. The present study reports the case of a 27‑year‑old woman that presented with superior vena cava syndrome and a large mass in the mediastinum, which was diagnosed as primary female mediastinal seminoma. The patient received 6 cycles of cisplatin‑based chemotherapy [4 cycles BEP chemotherapy (120 mg cisplatin, 0.45 g etoposide and 60 mg bleomycin, once every 3 weeks); 2 cycles IEP chemotherapy (120 mg cisplatin, 100 mg epirubicin and 6 g ifosfamide, once every 3 weeks)] and the patient showed an increase in the size of the mediastinal mass and hydropericardium, indicating a resistance to chemotherapy. Radiotherapy to the mediastinum (50 Gy over 18 fractions) and pericardium (30 Gy over 18 fractions) was performed. Following radiotherapy, the patient was considered to have a complete response to the treatment, and subsequent to a 5‑year follow‑up, no recurrence or metastasis was identified. To the best of our knowledge, no similar cases have been reported in the literature at present.
