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Case Report

Sarcomatoid urothelial carcinoma with chondrosarcomatous differentiation of the ureter: A case report and review of the literature

  • Authors:
    • Wei Lu
    • Yanjun Wang
    • Yonghong Li
    • Yun Cao
    • Hui Han
    • Fangjian Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Urology, State Key Laboratory of Oncology in Southern China, Sun Yat‑Sen University Cancer Center, Guangzhou, Guangdong 510060, P.R. China, Department of Pathology, State Key Laboratory of Oncology in Southern China, Sun Yat‑sen University Cancer Center, Guangzhou, Guangdong 510060, P.R. China
  • Pages: 1331-1337
    |
    Published online on: January 5, 2017
       https://doi.org/10.3892/ol.2017.5575
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Abstract

Sarcomatoid urothelial carcinoma of the urinary tract is associated with poor prognosis. The majority of sarcomatoid urothelial carcinomas are found in the urinary bladder, while a small minority have been shown to arise from the ureter. In the present case, a 72‑year‑old male patient was diagnosed with sarcomatoid urothelial carcinoma with chondrosarcomatous differentiation of the left ureter, and subsequently underwent nephroureterectomy and retroperitoneal lymph node dissection. Two lymph nodes from the renal hilum and one paraaortic lymph node were also found to have metastatic involvement; however, the patient refused to receive chemotherapy or radiotherapy and succumbed to bone and omentum metastasis at 6 months after the initial diagnosis. Sarcomatoid urothelial carcinoma of the ureter is uncommon. Even rarer is the presence of malignant heterologous elements, such as chondrosarcoma. The present study reports a rare case of sarcomatoid urothelial carcinoma with chondrosarcomatous differentiation of the ureter, as well as a review of the literature, in order to demonstrate the aggressive nature of this particular malignancy.
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1 

Beltran A Lopez, Sauter G, Gasser T, et al: Infiltrating urothelial carcinoma. World Health Organization Classification of Tumors. Pathology And GeneticsTumours of the Urinary System and Male Genital Organs. Eble JN, Sauter G, Epstein JI and Sesterhenn IA: IARC Press; Lyon: pp. 93–109. 2004

2 

Tanaka MF and Sonpavde G: Diagnosis and management of urothelial carcinoma of the bladder. Postgrad Med. 123:43–55. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Renner MJ: Primary malignant tumors of the ureter. Surg Gynecol Obstet. 52:793–803. 1931.

4 

Yano S, Arita M, Ueno F, Yoshida M, Ikegami K and Fukuda S: Carcinosarcoma of the ureter. Eur Urol. 10:711984.PubMed/NCBI

5 

Byard RW, Bell ME and Alkan MK: Primary carcinosarcoma: A rare cause of unilateral ureteral obstruction. J Urol. 137:732–733. 1987.PubMed/NCBI

6 

Fukuda T, Ohnishi Y, Sato K, Tachikawa S, Tamura T, Uehara T and Emura I: Transitional cell carcinoma with sarcomatous elements in the urinary tract. Six cases examined by immunohistochemistry. Acta Pathol Jpn. 41:143–149. 1991.PubMed/NCBI

7 

Tsutsumi M, Kamiya M, Sakamoto M, Tobisu K and Kakizoe T: A ureteral small cell carcinoma mixed with malignant mesodermal and ectodermal elements: A clinicopathological, morphological and immunohistochemical study. Jpn J Clin Oncol. 23:325–329. 1993.PubMed/NCBI

8 

Ishikura H, Kumagai F and Yoshiki T: Carcinosarcoma of the ureter with unusual histologic features. Jpn J Clin Oncol. 24:175–180. 1994.PubMed/NCBI

9 

Ichiyanagi N, Yamada T and Sakai Y: Carcinosarcoma of the ureter: A case report. (Abstract). Rinsho Hinyokika. 52:965–967. 1998.

10 

Maeda D, Fujii A, Yamaguchi K, Tominaga T, Fukayama M and Mori M: Sarcomatoid carcinoma with a predominant basaloid squamous carcinoma component: The first report of an unusual biphasic tumor of the ureter. Jpn J Clin Oncol. 37:878–883. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Völker HU, Zettl A, Schön G, Heller V, Heinrich E, Rosenwald A, Handwerker M, Müller-Hermelink HK, Marx A and Ströbel P: Molecular genetic findings in two cases of sarcomatoid carcinoma of the ureter: Evidence for evolution from a common pluripotent progenitor cell? Virchows Arch. 452:457–463. 2008. View Article : Google Scholar : PubMed/NCBI

12 

McDade HB, Armstrong EM and Graham AG: Proceedings: A case of carcinosarcoma of ureter. J Clin Pathol. 27:5141974. View Article : Google Scholar : PubMed/NCBI

13 

Murata T, Soga T, Tajima K, Saito K, Komeda Y, Ioshii SO, Shiraishi T, Sakakura T and Yatani R: Sarcomatoid carcinoma of the urinary tract. Pathol Int. 44:138–144. 1994. View Article : Google Scholar : PubMed/NCBI

14 

Burt JD, Murphy D and Heffernan EB: Carcinosarcoma of the ureter presenting as biliary colic. Aust N Z J Surg. 65:63–64. 1995. View Article : Google Scholar : PubMed/NCBI

15 

Nagayoshi J, Kawakami T and Maruyama Y: Sarcomatoid carcinoma of the ureter: A case report. Int J Urol. 4:618–620. 1997. View Article : Google Scholar : PubMed/NCBI

16 

Perimenis P, Athanasopoulos A, Geragthy J and Speakman M: Carcinosarcoma of the ureter: A rare, pleomorphic, aggressive malignancy. Int Urol Nephrol. 35:491–493. 2003. View Article : Google Scholar : PubMed/NCBI

17 

Lee G, Rankin A, Williamson M and Pope A: Case report: Sarcomatoid carcinoma arising from the ureter: A rare case and a treatment dilemma. Int Urol Nephrol. 36:153–154. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Busby JE, Brown GA, Tamboli P, Kamat AM, Dinney CP, Grossman HB and Matin SF: Upper urinary tract tumors with nontransitional histology: A single-center experience. Urology. 67:518–523. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Petsch MJ, Planz B, Tschahargane C and Caspers HP: Primary sarcomatoid carcinoma of the ureter. Aktuelle Urol. 35:137–139. 2004.(In German). View Article : Google Scholar : PubMed/NCBI

20 

Kakoi N, Miyajima A, Motizuku T, Mizuguchi Y, Asano T and Hayakawa M: Carcinosarcoma of the renal pelvis and ureter: A case report. Hinyokika Kiyo. 48:29–32. 2002.(In Japanese). PubMed/NCBI

21 

Nicolas MM, Nazarullah A and Guo CC: Sarcomatoid urothelial carcinoma with chondrosarcomatous differentiation of the ureter: A case report. Anal Quant Cytopathol Histpathol. 36:111–116. 2014.PubMed/NCBI

22 

Darko A, Das K, Bhalla RS and Heller D: Carcinosarcoma of the ureter: Report of a case with unusual histology and review of the literature. Int J Urol. 13:1528–1531. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Johnin K, Kadowaki T, Kushima M, Ushida H, Koizumi S and Okada Y: Primary heterologous carcinosarcoma of the ureter with necrotic malignant polyps. Report of a case and review of the literature. Urol Int. 70:232–235. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Fleming S: Carcinosarcoma (mixed mesodermal tumor) of the ureter. J Urol. 138:1234–1235. 1987.PubMed/NCBI

25 

Lopez-Beltran A, Pacelli A, Rothenberg HJ, Wollan PC, Zincke H, Blute ML and Bostwick DG: Carcinosarcoma and sarcomatoid carcinoma of the bladder: Clinicopathological study of 41 cases. J Urol. 159:1497–1503. 1998. View Article : Google Scholar : PubMed/NCBI

26 

Clark PE, Agarwal N, Biagioli MC, Eisenberger MA, Greenberg RE, Herr HW, Inman BA, Kuban DA, Kuzel TM, Lele SM, et al: Bladder cancer. J Natl Compr Canc Netw. 11:446–475. 2013.PubMed/NCBI

27 

Eble JN, Sauter G, Epstein J and Sesterhenn I: World Health Organiztion Classification of Tumours: Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs. 7. 3rd. IARC Press; Lyon: 2004

28 

Sung MT, Wang M, MacLennan GT, Eble JN, Tan PH, Lopez-Beltran A, Montironi R, Harris JJ, Kuhar M and Cheng L: Histogenesis of sarcomatoid urothelial carcinoma of the urinary bladder: Evidence for a common clonal origin with divergent differentiation. J Pathol. 211:420–430. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Gira FA, Barbieri A, Fellegara G, Zompatori M and Corradi D: Dedifferentiated chromophobe renal cell carcinoma with massive osteosarcoma-like divergent differentiation: A singular entity in the spectrum of retroperitoneal calcifying tumors. Int J Surg Pathol. 18:419–423. 2010.PubMed/NCBI

30 

Cserni G, Kovács BR, Tarján M, Sápi Z, Domján Z and Szabó Z: Sarcomatoid renal cell carcinoma with foci of chromophobe carcinoma. Pathol Oncol Res. 8:142–144. 2002. View Article : Google Scholar : PubMed/NCBI

31 

Wang X, MacLennan GT, Zhang S, Montironi R, Lopez-Beltran A, Tan PH, Foster S, Baldridge LA and Cheng L: Sarcomatoid carcinoma of the upper urinary tract: Clinical outcome and molecular characterization. Hum Pathol. 40:211–217. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Lichtenstein L and Bernstein D: Unusual benign and malignant chondroid tumors of bone. A survey of some mesenchymal cartilage tumors and malignant chondroblastic tumors, including a few multicentric ones, as well as many atypical benign chondroblastomas and chondromyxoid fibromas. Cancer. 12:1142–1157. 1959. View Article : Google Scholar : PubMed/NCBI

33 

Bahr AL and Gayler BW: Cranial chondrosarcomas. Report of four cases and review of the literature. Radiology. 124:151–156. 1977. View Article : Google Scholar : PubMed/NCBI

34 

Huvos AG, Rosen G, Dabska M and Marcove RC: Mesenchymal chondrosarcoma. A clinicopathologic analysis of 35 patients with emphasis on treatment. Cancer. 51:1230–1237. 1983. View Article : Google Scholar : PubMed/NCBI

35 

Shapeero LG, Vanel D, Couanet D, Contesso G and Ackerman LV: Extraskeletal mesenchymal chondrosarcoma. Radiology. 186:819–826. 1993. View Article : Google Scholar : PubMed/NCBI

36 

Yilmaz E, Birlik B, Arican Z and Guney S: Carcinosarcoma of the renal pelvis and urinary bladder: A case report. Korean J Radiol. 4:255–259. 2003. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lu W, Wang Y, Li Y, Cao Y, Han H and Zhou F: Sarcomatoid urothelial carcinoma with chondrosarcomatous differentiation of the ureter: A case report and review of the literature. Oncol Lett 13: 1331-1337, 2017.
APA
Lu, W., Wang, Y., Li, Y., Cao, Y., Han, H., & Zhou, F. (2017). Sarcomatoid urothelial carcinoma with chondrosarcomatous differentiation of the ureter: A case report and review of the literature. Oncology Letters, 13, 1331-1337. https://doi.org/10.3892/ol.2017.5575
MLA
Lu, W., Wang, Y., Li, Y., Cao, Y., Han, H., Zhou, F."Sarcomatoid urothelial carcinoma with chondrosarcomatous differentiation of the ureter: A case report and review of the literature". Oncology Letters 13.3 (2017): 1331-1337.
Chicago
Lu, W., Wang, Y., Li, Y., Cao, Y., Han, H., Zhou, F."Sarcomatoid urothelial carcinoma with chondrosarcomatous differentiation of the ureter: A case report and review of the literature". Oncology Letters 13, no. 3 (2017): 1331-1337. https://doi.org/10.3892/ol.2017.5575
Copy and paste a formatted citation
x
Spandidos Publications style
Lu W, Wang Y, Li Y, Cao Y, Han H and Zhou F: Sarcomatoid urothelial carcinoma with chondrosarcomatous differentiation of the ureter: A case report and review of the literature. Oncol Lett 13: 1331-1337, 2017.
APA
Lu, W., Wang, Y., Li, Y., Cao, Y., Han, H., & Zhou, F. (2017). Sarcomatoid urothelial carcinoma with chondrosarcomatous differentiation of the ureter: A case report and review of the literature. Oncology Letters, 13, 1331-1337. https://doi.org/10.3892/ol.2017.5575
MLA
Lu, W., Wang, Y., Li, Y., Cao, Y., Han, H., Zhou, F."Sarcomatoid urothelial carcinoma with chondrosarcomatous differentiation of the ureter: A case report and review of the literature". Oncology Letters 13.3 (2017): 1331-1337.
Chicago
Lu, W., Wang, Y., Li, Y., Cao, Y., Han, H., Zhou, F."Sarcomatoid urothelial carcinoma with chondrosarcomatous differentiation of the ureter: A case report and review of the literature". Oncology Letters 13, no. 3 (2017): 1331-1337. https://doi.org/10.3892/ol.2017.5575
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