Philadelphia chromosome with acute myeloid leukemia and concurrent large B cell lymphoma of different origins: A case report

Dai,Yang; Shuai,Xiao; Kuang,Pu; Wang,Lin; Liu,Ting; Niu,Ting

doi:10.3892/ol.2017.5578

Philadelphia chromosome with acute myeloid leukemia and concurrent large B cell lymphoma of different origins: A case report

Authors:
- Yang Dai
- Xiao Shuai
- Pu Kuang
- Lin Wang
- Ting Liu
- Ting Niu
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Affiliations: Department of Hematology and Research Laboratory of Hematology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Department of Pathology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China
Published online on: January 10, 2017 https://doi.org/10.3892/ol.2017.5578
Pages: 1189-1193
Copyright: © Dai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Philadelphia chromosome with de novo acute myeloid leukemia (Ph + AML) arising from t(9;22) is an uncommon occurrence. Ph + AML is known to respond poorly to conventional chemotherapy. To the best of our knowledge, simultaneous diagnosis of de novo Ph + AML and lymphoma in a single patient has not yet been reported. The present study reports the case of a 37‑year‑old female patient who presented with bone pain, fever and lymphadenopathy, and was diagnosed as Ph + AML with concurrent diffuse large B cell lymphoma. Combined chemotherapy regimen covering AML and lymphoma was administered, achieving short‑term response. However, the therapy soon failed and the patient succumbed to the disease. The present study reports the first case of Ph + AML occurring concurrently with diffuse large B cell lymphoma, and discusses certain differences between Ph + AML and chronic myelogenous leukemia in the myeloid blast crisis phase, as well as the appropriate therapeutic modalities for Ph + AML. In addition, the potential association between Ph + AML and diffuse large B cell lymphoma in this patient was investigated.

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1	Faderl S, Talpaz M, Estrov Z, O'Brien S, Kurzrock R and Kantarjian HM: The biology of chronic myeloid leukemia. N Engl J Med. 341:164–172. 1999. View Article : Google Scholar : PubMed/NCBI
2	Fielding AK: How I treat Philadelphia chromosome-positive acute lymphoblastic leukemia. Blood. 116:3409–3417. 2010. View Article : Google Scholar : PubMed/NCBI
3	Deschler B and Lübbert M: Acute myeloid leukemia: Epidemiology and etiology. Cancer. 107:2099–2107. 2006. View Article : Google Scholar : PubMed/NCBI
4	Vardiman JW, Thiele J, Arber DA, Brunning RD, Borowitz MJ, Porwit A, Harris NL, Le Beau MM, Hellström-Lindberg E, Tefferi A and Bloomfield CD: The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: Rationale and important changes. Blood. 114:937–951. 2009. View Article : Google Scholar : PubMed/NCBI
5	Paietta E, Racevskis J, Bennett JM, Neuberg D, Cassileth PA, Rowe JM and Wiernik PH: Biologic heterogeneity in Philadelphia chromosome-positive acute leukemia with myeloid morphology: The eastern cooperative oncology group experience. Leukemia. 12:1881–1885. 1998. View Article : Google Scholar : PubMed/NCBI
6	Keung YK, Beaty M, Powell BL, Molnar I, Buss D and Pettenati M: Philadelphia chromosome positive myelodysplastic syndrome and acute myeloid leukemia-retrospective study and review of literature. Leuk Res. 28:579–586. 2004. View Article : Google Scholar : PubMed/NCBI
7	Berger R: Differences between blastic chronic myeloid leukemia and Ph-positive acute leukemia. Leuk Lymphoma. 11:(Suppl 1). 235–237. 1993. View Article : Google Scholar : PubMed/NCBI
8	Soupir CP, Vergilio JA, Dal Cin P, Muzikansky A, Kantarjian H, Jones D and Hasserjian RP: Philadelphia chromosome-positive acute myeloid leukemia: A rare aggressive leukemia with clinicopathologic features distinct from chronic myeloid leukemia in myeloid blast crisis. Am J Clin Pathol. 127:642–650. 2007. View Article : Google Scholar : PubMed/NCBI
9	Cuneo A, Ferrant A, Michaux JL, Demuynck H, Boogaerts M, Louwagie A, Doyen C, Stul M, Cassiman JJ, Dal Cin P, et al: Philadelphia chromosome-positive acute myeloid leukemia: Cytoimmunologic and cytogenetic features. Haematologica. 81:423–427. 1996.PubMed/NCBI
10	Konoplev S, Yin CC, Kornblau SM, Kantarjian HM, Konopleva M, Andreeff M, Lu G, Zuo Z, Luthra R, Medeiros LJ and Bueso-Ramos CE: Molecular characterization of De novo Philadelphia chromosome-positive acute myeloid leukemia. Leuk Lymphoma. 54:138–144. 2013. View Article : Google Scholar : PubMed/NCBI
11	Nacheva EP, Grace CD, Brazma D, Gancheva K, Howard-Reeves J, Rai L, Gale RE, Linch DC, Hills RK, Russell N, et al: Does BCR/ABL1 positive acute myeloid leukaemia exist? Br J Haematol. 161:541–550. 2013. View Article : Google Scholar : PubMed/NCBI
12	Ito K, Tominaga K, Suzuki T, Jinnai I and Bessho M: Successful treatment with imatinib mesylate in a case of minor BCR-ABL-positive acute myelogenous leukemia. Int J Hematol. 81:242–245. 2005. View Article : Google Scholar : PubMed/NCBI
13	Jentsch-Ullrich K, Pelz AF, Braun H, Koenigsmann M, Mohren M, Wieacker P and Franke A: Complete molecular remission in a patient with Philadelphia-chromosome positive acute myeloid leukemia after conventional therapy and imatinib. Haematologica. 89:ECR152004.PubMed/NCBI
14	Yamaguchi M and Konishi I: Successful treatment with imatinib mesylate for Philadelphia chromosome-positive refractory acute myeloid leukemia. Rinsho Ketsueki. 44:254–256. 2003.PubMed/NCBI
15	Lazarevici V, Golovleva I, Nygren I and Wahlin A: Induction chemotherapy and post-remission Imatinib therapy for De novo BCR-ABL positive AML. Am J Hematol. 81:470–471. 2006. View Article : Google Scholar : PubMed/NCBI
16	Kondo T, Tasaka T, Sano F, Matsuda K, Kubo Y, Matsuhashi Y, Nakanishi H, Sadahira Y, Wada H, Sugihara T and Tohyama K: Philadelphia chromosome-positive acute myeloid leukemia (Ph +AML) treated with imatinib mesylate (IM): A report with IM plasma concentration and bcr-abl transcripts. Leuk Res. 33:e137–e138. 2009. View Article : Google Scholar : PubMed/NCBI
17	Sun J, Wang Z, Luo Y, Tan Y, Allan DS and Huang H: Prolonged survival with imatinib mesylate combined with chemotherapy and allogeneic stem cell transplantation in De novo Ph+ acute myeloid leukemia. Acta Haematol. 127:143–148. 2012. View Article : Google Scholar : PubMed/NCBI
18	Bacher U, Haferlach T, Alpermann T, Zenger M, Hochhaus A, Beelen DW, Uppenkamp M, Rummel M, Kern W, Schnittger S and Haferlach C: Subclones with the t(9;22)/BCR-ABL1 rearrangement occur in AML and seem to cooperate with distinct genetic alterations. Br J Haematol. 152:713–720. 2011. View Article : Google Scholar : PubMed/NCBI
19	Kapadia SB and Kaplan SS: Simultaneous occurrence of non-Hodgkin's lymphoma and acute myelomonocytic leukemia. Cancer. 38:2557–2560. 1976. View Article : Google Scholar : PubMed/NCBI
20	Youness E, Ahearn MJ and Drewinko B: Simultaneous occurrence of non-Hodgkin's lymphoma and spontaneous acute granulocytic leukemia. Am J Clin Pathol. 70:415–420. 1978. View Article : Google Scholar : PubMed/NCBI
21	Ohwada C, Nakaseko C, Tanaka H, Abe D, Oda K, Ozawa S, Takeuchi M, Shimizu N, Cho R, Saito Y and Nishimura M: Successful matched unrelated BMT for secondary AML which developed simultaneously with relapsed Hodgkin's lymphoma. Bone Marrow Transplant. 39:569–570. 2007. View Article : Google Scholar : PubMed/NCBI
22	Jaalouk G, Avvisati G, Latagliata R, Pacchiarotti A, Pulsoni A, Mecarocci S and Malagnino F: Simultaneous occurrence of large B-cell non-Hodgkin lymphoma and myelodysplastic syndrome rapidly evolving into acute myeloblastic leukemia. Leuk Lymphoma. 21:339–341. 1996. View Article : Google Scholar : PubMed/NCBI
23	Montefusco E, Fazi F, Cordone I, Ariola C, Nanni M, Spadea A, Spiriti MA, Fenu S, Mandelli F and Petti MC: Molecular remission following high-dose hydroxyurea and fludarabine plus cytarabine in a patient with simultaneous acute myeloid leukemia and low-grade lymphoma. Leuk Lymphoma. 40:671–674. 2001. View Article : Google Scholar : PubMed/NCBI
24	Janossy G, Woodruff RK, Paxton A, Greaves MF, Capellaro D, Kirk B, Innes EM, Eden OB, Lewis C, Catovsky D and Hoffbrand AV: Membrane marker and cell separation studies in Ph1-positive leukemia. Blood. 51:861–877. 1978.PubMed/NCBI
25	Cauwelier B, Nollet F, De Laere E, Van Leeuwen M, Billiet J, Criel A and Louwagie A: Simultaneous occurrence of myelodysplastic syndrome and monoclonal B lymphocytes with a different clonal origin. Leuk Lymphoma. 43:191–193. 2002. View Article : Google Scholar : PubMed/NCBI