Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
March-2017 Volume 13 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2017 Volume 13 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Karyopherin alpha 2 expression is a novel diagnostic and prognostic factor for colorectal cancer

  • Authors:
    • Lei Yu
    • Guiyu Wang
    • Qian Zhang
    • Li Gao
    • Rui Huang
    • Yinggang Chen
    • Qingchao Tang
    • Jin Liu
    • Chunjia Liu
    • Hongwei Wang
    • Xishan Wang
  • View Affiliations / Copyright

    Affiliations: Department of Colorectal Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China, Department of Oral Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China, Department of Pathology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China, Department of Histology and Embryology, Basic Medical Science College, Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China, Department of Colorectal Surgery, Cancer Hospital of Chinese Academy of Medical Sciences, Beijing 100021, P.R. China
    Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1194-1200
    |
    Published online on: January 10, 2017
       https://doi.org/10.3892/ol.2017.5579
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Colorectal cancer (CRC) is the fourth most common cancer and the second leading cause of cancer‑associated mortality in Western countries. CRC treatment is dependent on the preoperative and postoperative condition of patients. At present, the prognostic value of conventional parameters for the estimation of patient prognosis is limited. The aim of the present study was to investigate the expression of karyopherin α2 (KPNA2) in cancerous and healthy colon tissues and to evaluate the prognostic factors for patients with primary CRC. KPNA2 expression in CRC and paired normal tissues was analyzed by immunohistochemistry and reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR). In addition, serum KPNA2 expression was evaluated by enzyme‑linked immunosorbent assay. Subsequently, the association between KPNA2 expression in CRC tissues and patient clinicopathological features was analyzed. Kaplan‑Meier analysis was utilized to investigate the prognostic value of KPNA2 expression on overall survival rates following radical surgery for the treatment of CRC. Immunohistochemistry and RT‑qPCR revealed that KPNA2 expression was significantly increased in CRC tissues compared with paired normal tissues. Serum KPNA2 expression was significantly increased in CRC patients compared with healthy individuals. Furthermore, KPNA2 expression was observed to positively correlate with Tumor‑Node‑Metastasis stage, lymph node involvement, tumor differentiation, infiltration depth, lymphovascular invasion and perineural invasion, which are factors known to affect the prognosis of CRC patients following surgery. In addition, increased KPNA2 expression was associated with decreased overall survival and disease‑free survival rates. Patients not suited for surveillance regimens may be identified at initial biopsy test with a positive KPNA2 immunohistochemistry. Increased serum expression of KPNA2 may be utilized as a diagnostic factor for patients with CRC. High nuclear KPNA2 expression may serve as a novel predictor of survival following radical colorectal surgery in CRC patients. The results of the present study may improve individualized risk stratification, leading to the optimization of therapies for CRC patients.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Brenner H, Kloor M and Pox CP: Colorectal cancer. Lancet. 65:1490–1502. 2014. View Article : Google Scholar

2 

Kau TR, Way JC and Silver PA: Nuclear transport and cancer: From mechanism to intervention. Nat Rev Cancer. 4:106–117. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Goldfarb DS, Corbett AH, Mason DA, Harreman MT and Adam SA: Importin alpha: A multipurpose nuclear-transport receptor. Trends Cell Biol. 14:505–514. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Christiansen A and Dyrskjøt L: The functional role of the novel biomarker karyopherin α 2 (KPNA2) in cancer. Cancer Lett. 331:18–23. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Radu A, Blobel G and Moore MS: Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. Proc Natl Acad Sci USA. 92:1769–1773. 1995. View Article : Google Scholar : PubMed/NCBI

6 

Kotera I, Sekimoto T, Miyamoto Y, Saiwaki T, Nagoshi E, Sakagami H, Kondo H and Yoneda Y: Importin alpha transports CaMKIV to the nucleus without utilizing importin beta. EMBO J. 24:942–951. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Stewart M: Molecular mechanism of the nuclear protein import cycle. Nat Rev Mol Cell Biol. 8:195–208. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Livak and Schmittgen, . Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCt method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

9 

Dahl E, Kristiansen G, Gottlob K, Klaman I, et al: Molecular profiling of laser-microdissected matched tumor and normal breast tissue identifies karyopherin alpha2 as a potential novel prognostic marker in breast cancer. Clin Cancer Res. 12:3950–3960. 2006. View Article : Google Scholar : PubMed/NCBI

10 

van der Watt PJ, Maske CP, Hendricks DT, Parker MI, Denny L, Govender D, Birrer MJ and Leaner VD: The Karyopherin proteins, Crm1 and Karyopherin beta1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation. Int J Cancer. 124:1829–1840. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Sakai M, Sohda M, Miyazaki T, Suzuki S, Sano A, Tanaka N, Inose T, Nakajima M, Kato H and Kuwano H: Significance of karyopherin-{alpha} 2 (KPNA2) expression in esophageal squamous cell carcinoma. Anticancer Res. 30:851–856. 2010.PubMed/NCBI

12 

Winnepenninckx V, Lazar V, Michiels S, Dessen P, Stas M, Alonso SR, Avril MF, Romero PL Ortiz, Robert T, Balacescu O, et al: Gene expression profiling of primary cutaneous melanoma and clinical outcome. J Natl Cancer Inst. 98:472–482. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Wang CI, Wang CL, Wang CW, Chen CD, Wu CC, Liang Y, Tsai YH, Chang YS, Yu JS and Yu CJ: Importin subunit alpha-2 is identified as a potential biomarker for non-small cell lung cancer by integration of the cancer cell secretome and tissue transcriptome. Int J Cancer. 128:2364–2372. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Li C, Ji L, Ding ZY, Zhang QD and Huang GR: Overexpression of KPNA2 correlates with poor prognosis in patients with gastric adenocarcinoma. Tumour Biol. 34:1021–1026. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Mortezavi A, Hermanns T, Seifert HH, et al: KPNA2 expression is an independent adverse predictor of biochemical recurrence after radical prostatectomy. Clin Cancer Res. 17:1111–1121. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Gousias K, Becker AJ, Simon M and Niehusmann P: Nuclear karyopherin a2: A novel biomarker for infiltrative astrocytomas. J Neurooncol. 109:545–553. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Yoshitake K, Tanaka S, Mogushi K, et al: Importin-α1 as a novel prognostic target for hepatocellular carcinoma. Ann Surg Oncol. 18:2093–2103. 2011. View Article : Google Scholar : PubMed/NCBI

18 

He L, Ding H, Wang JH, et al: Overexpression of karyopherin 2 in human ovarian malignant germ cell tumor correlates with poor prognosis. PLoS One. 7:e429922012. View Article : Google Scholar : PubMed/NCBI

19 

Stochaj U, Rassadi R and Chiu J: Stress-mediated inhibition of the classical nuclear protein import pathway and nuclear accumulation of the small GTPase Gsp1p. FASEB J. 14:2130–2132. 2000.PubMed/NCBI

20 

Furuta M, Kose S, Koike M, et al: Heat-shock induced nuclear retention and recycling inhibition of importin alpha. Genes Cells. 9:429–441. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Kodiha M, Chu A, Matusiewicz N and Stochaj U: Multiple mechanisms promote the inhibition of classical nuclear import upon exposure to severe oxidative stress. Cell Death Differ. 11:862–874. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Miyamoto Y, Saiwaki T, Yamashita J, Yasuda Y, Kotera I, Shibata S, Shigeta M, Hiraoka Y, Haraguchi T and Yoneda Y: Cellular stresses induce the nuclear accumulation of importin alpha and cause a conventional nuclear import block. J Cell Biol. 165:617–623. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Trachootham D, Alexandre J and Huang P: Targeting cancer cells by ROS-mediated mechanisms: A radical therapeutic approach? Nat Rev Drug Discov. 8:579–591. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Yasuda Y, Miyamoto Y, Yamashiro T, Asally M, Masui A, Wong C, Loveland KL and Yoneda Y: Nuclear retention of importin α coordinates cell fate through changes in gene expression. EMBO J. 31:83–94. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Miyamoto Y, Loveland KL and Yoneda Y: Nuclear importin α and its physiological importance. Commun Integr Biol. 5:220–222. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Umegaki N, Tamai K, Nakano H, Moritsugu R, Yamazaki T, Hanada K, Katayama I and Kaneda Y: Differential regulation of karyopherin alpha 2 expression by TGF-beta1 and IFN-gamma in normal human epidermal keratinocytes: Evident contribution of KPNA2 for nuclear translocation of IRF-1. J Invest Dermatol. 127:1456–1464. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Noetzel E, Rose M, Bornemann J, Gajewski M, Knüchel R and Dahl E: Nuclear transport receptor karyopherin-α2 promotes malignant breast cancer phenotypes in vitro. Oncogene. 31:2101–2114. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Hall MN, Griffin CA, Simionescu A, Corbett AH and Pavlath GK: Distinct roles for classical nuclear import receptors in the growth of multinucleated muscle cells. Dev Biol. 357:248–258. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Giuliani L, Ronci C, Bonifacio D, Di Bonito L, Favalli C, Perno CF, Syrjänen K and Ciotti M: Detection of oncogenic DNA viruses in colorectal cancer. Anticancer Res. 28:1405–1410. 2008.PubMed/NCBI

30 

Fischer N, Kremmer E, Lautscham G, Mueller-Lantzsch N and Grässer FA: Epstein-Barr virus nuclear antigen 1 forms a complex with the nuclear transporter karyopherin alpha2. J Biol Chem. 272:3999–4005. 1997. View Article : Google Scholar : PubMed/NCBI

31 

Nelson LM, Rose RC, LeRoux L, Lane C, Bruya K and Moroianu J: Nuclear import and DNA binding of human papillomavirus type 45 L1 capsid protein. J Cell Biochem. 79:225–238. 2000. View Article : Google Scholar : PubMed/NCBI

32 

Le Roux LG and Moroianu J: Nuclear entry of high-risk human papillomavirus type 16 E6 oncoprotein occurs via several pathways. J Virol. 77:2330–2337. 2003. View Article : Google Scholar : PubMed/NCBI

33 

Qu Q, Sawa H, Suzuki T, Semba S, Henmi C, Okada Y, Tsuda M, Tanaka S, Atwood WJ and Nagashima K: Nuclear entry mechanism of the human polyomavirus JC virus-like particle: Role of importins and the nuclear pore complex. J Biol Chem. 279:27735–27742. 2004. View Article : Google Scholar : PubMed/NCBI

34 

Gallay P, Stitt V, Mundy C, Oettinger M and Trono D: Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import. J Virol. 70:1027–1032. 1996.PubMed/NCBI

35 

Bird G, O'Donnell M, Moroianu J and Garcea RL: Possible role for cellular karyopherins in regulating polyomavirus and papillomavirus capsid assembly. J Virol. 82:9848–9857. 2008. View Article : Google Scholar : PubMed/NCBI

36 

Narod SA and Foulkes WD: BRCA1 and BRCA2: 1994 and beyond. Nat Rev Cancer. 4:665–676. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Teng SC, Wu KJ, Tseng SF, Wong CW and Kao L: Importin KPNA2, NBS1, DNA repair and tumorigenesis. J Mol Histol. 37:293–299. 2006. View Article : Google Scholar : PubMed/NCBI

38 

Cutress ML, Whitaker HC, Mills IG, Stewart M and Neal DE: Structural basis for the nuclear import of the human androgen receptor. J Cell Sci. 121:957–968. 2008. View Article : Google Scholar : PubMed/NCBI

39 

Kamikawa Y, Yasuhara N and Yoneda Y: Cell type-specific transcriptional regulation of the gene encoding importin-alpha1. Exp Cell Res. 317:1970–1978. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Dankof A, Fritzsche FR, Dahl E, Pahl S, Wild P, Dietel M, Hartmann A and Kristiansen G: KPNA2 protein expression in invasive breast carcinoma and matched peritumoral ductal carcinoma in situ. Virchows Arch. 451:877–881. 2007. View Article : Google Scholar : PubMed/NCBI

41 

Gluz O, Wild P, Meiler R, Diallo-Danebrock R, Ting E, Mohrmann S, Schuett G, Dahl E, Fuchs T, Herr A, et al: Nuclear karyopherin alpha2 expression predicts poor survival in patients with advanced breast cancer irrespective of treatment intensity. Int J Cancer. 123:1433–1438. 2008. View Article : Google Scholar : PubMed/NCBI

42 

Altan B, Yokobori T, Mochiki E, Ohno T, Ogata K, Ogawa A, Yanai M, Kobayashi T, Luvsandagva B, Asao T and Kuwano H: Nuclear karyopherin-α2 expression in primary lesions and metastatic lymph nodes was associated with poor prognosis and progression in gastric cancer. Carcinogenesis. 34:2314–2321. 2013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yu L, Wang G, Zhang Q, Gao L, Huang R, Chen Y, Tang Q, Liu J, Liu C, Wang H, Wang H, et al: Karyopherin alpha 2 expression is a novel diagnostic and prognostic factor for colorectal cancer. Oncol Lett 13: 1194-1200, 2017.
APA
Yu, L., Wang, G., Zhang, Q., Gao, L., Huang, R., Chen, Y. ... Wang, X. (2017). Karyopherin alpha 2 expression is a novel diagnostic and prognostic factor for colorectal cancer. Oncology Letters, 13, 1194-1200. https://doi.org/10.3892/ol.2017.5579
MLA
Yu, L., Wang, G., Zhang, Q., Gao, L., Huang, R., Chen, Y., Tang, Q., Liu, J., Liu, C., Wang, H., Wang, X."Karyopherin alpha 2 expression is a novel diagnostic and prognostic factor for colorectal cancer". Oncology Letters 13.3 (2017): 1194-1200.
Chicago
Yu, L., Wang, G., Zhang, Q., Gao, L., Huang, R., Chen, Y., Tang, Q., Liu, J., Liu, C., Wang, H., Wang, X."Karyopherin alpha 2 expression is a novel diagnostic and prognostic factor for colorectal cancer". Oncology Letters 13, no. 3 (2017): 1194-1200. https://doi.org/10.3892/ol.2017.5579
Copy and paste a formatted citation
x
Spandidos Publications style
Yu L, Wang G, Zhang Q, Gao L, Huang R, Chen Y, Tang Q, Liu J, Liu C, Wang H, Wang H, et al: Karyopherin alpha 2 expression is a novel diagnostic and prognostic factor for colorectal cancer. Oncol Lett 13: 1194-1200, 2017.
APA
Yu, L., Wang, G., Zhang, Q., Gao, L., Huang, R., Chen, Y. ... Wang, X. (2017). Karyopherin alpha 2 expression is a novel diagnostic and prognostic factor for colorectal cancer. Oncology Letters, 13, 1194-1200. https://doi.org/10.3892/ol.2017.5579
MLA
Yu, L., Wang, G., Zhang, Q., Gao, L., Huang, R., Chen, Y., Tang, Q., Liu, J., Liu, C., Wang, H., Wang, X."Karyopherin alpha 2 expression is a novel diagnostic and prognostic factor for colorectal cancer". Oncology Letters 13.3 (2017): 1194-1200.
Chicago
Yu, L., Wang, G., Zhang, Q., Gao, L., Huang, R., Chen, Y., Tang, Q., Liu, J., Liu, C., Wang, H., Wang, X."Karyopherin alpha 2 expression is a novel diagnostic and prognostic factor for colorectal cancer". Oncology Letters 13, no. 3 (2017): 1194-1200. https://doi.org/10.3892/ol.2017.5579
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team