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Metabolic profiling of hepatitis B virus‑related hepatocellular carcinoma with diverse differentiation grades

  • Authors:
    • Lei Zhang
    • Ya Huang
    • Mingjian Lian
    • Zhijuan Fan
    • Yaqiong Tian
    • Yufan Wang
    • Hua Kang
    • Shuang Liu
    • Shuye Liu
    • Tong Li
    • Zhongqiang Shan
  • View Affiliations / Copyright

    Affiliations: Tianjin Key Laboratory of Artificial Cell, Artificial Cell Engineering Technology Research Center of Public Health Ministry, Tianjin Third Central Hospital, Tianjin 300170, P.R. China, Clinical Laboratory Department, Chongqing City First People's Hospital of Wanzhou, Chongqing 404040, P.R. China, Clinical Laboratory Department, Third Central Clinical College, Tianjin Medical University, Tianjin 300070, P.R. China, Tianjin Key Laboratory of Artificial Cell, Clinical Laboratory Department, Tianjin Third Central Hospital, Tianjin 300170, P.R. China, Chemical Engineering Institute, Tianjin University, Tianjin 300072, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1204-1210
    |
    Published online on: January 11, 2017
       https://doi.org/10.3892/ol.2017.5596
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Abstract

The most effective diagnostic tool for the majority of hepatocellular carcinoma (HCC) patients is determining the differentiation grade of their tumors. However liver biopsies, which are currently the most effective way of determining tumor differentiation grade, have several limitations. The present study was designed to select serum characteristic metabolites that correlate with the differentiation grades of hepatitis B virus (HBV)‑related HCC, and so could be used in the clinic as a non‑invasive method of differentiating patients with different grades of HCC. A total of 58 patients with HBV‑related HCC were included in the present study, and divided into three groups according to their tumor differentiation grade. A further 20 patients with HBV‑related liver cirrhosis and 19 healthy volunteers were enrolled. Ultra‑performance liquid chromatography‑mass spectrometry was used to analyze endogenous metabolites. Multivariate statistical analysis was used to examine the data using MZmine 2.0 software. The 14 metabolites that were highly correlated with specific differentiation grades of HCC were then selected for additional study. Receiver operator characteristic curve analysis was used to evaluate their clinical value. In total, 5 metabolites were finally identified, including lysophosphatidylcholine (16:0), oleamide, monoglyceride (0:0/15:0/0:0), lysophosphatidylcholine (18:0) and lysophosphatidylcholine [22:5(7Z,10Z,13Z,16Z,19Z)]. All these metabolites exhibited an excellent ability to distinguish different types of HCC with various differentiation grades and the area under the curve of these metabolites was up to 0.942, showing promising clinical value.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang L, Huang Y, Lian M, Fan Z, Tian Y, Wang Y, Kang H, Liu S, Liu S, Li T, Li T, et al: Metabolic profiling of hepatitis B virus‑related hepatocellular carcinoma with diverse differentiation grades. Oncol Lett 13: 1204-1210, 2017.
APA
Zhang, L., Huang, Y., Lian, M., Fan, Z., Tian, Y., Wang, Y. ... Shan, Z. (2017). Metabolic profiling of hepatitis B virus‑related hepatocellular carcinoma with diverse differentiation grades. Oncology Letters, 13, 1204-1210. https://doi.org/10.3892/ol.2017.5596
MLA
Zhang, L., Huang, Y., Lian, M., Fan, Z., Tian, Y., Wang, Y., Kang, H., Liu, S., Liu, S., Li, T., Shan, Z."Metabolic profiling of hepatitis B virus‑related hepatocellular carcinoma with diverse differentiation grades". Oncology Letters 13.3 (2017): 1204-1210.
Chicago
Zhang, L., Huang, Y., Lian, M., Fan, Z., Tian, Y., Wang, Y., Kang, H., Liu, S., Liu, S., Li, T., Shan, Z."Metabolic profiling of hepatitis B virus‑related hepatocellular carcinoma with diverse differentiation grades". Oncology Letters 13, no. 3 (2017): 1204-1210. https://doi.org/10.3892/ol.2017.5596
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang L, Huang Y, Lian M, Fan Z, Tian Y, Wang Y, Kang H, Liu S, Liu S, Li T, Li T, et al: Metabolic profiling of hepatitis B virus‑related hepatocellular carcinoma with diverse differentiation grades. Oncol Lett 13: 1204-1210, 2017.
APA
Zhang, L., Huang, Y., Lian, M., Fan, Z., Tian, Y., Wang, Y. ... Shan, Z. (2017). Metabolic profiling of hepatitis B virus‑related hepatocellular carcinoma with diverse differentiation grades. Oncology Letters, 13, 1204-1210. https://doi.org/10.3892/ol.2017.5596
MLA
Zhang, L., Huang, Y., Lian, M., Fan, Z., Tian, Y., Wang, Y., Kang, H., Liu, S., Liu, S., Li, T., Shan, Z."Metabolic profiling of hepatitis B virus‑related hepatocellular carcinoma with diverse differentiation grades". Oncology Letters 13.3 (2017): 1204-1210.
Chicago
Zhang, L., Huang, Y., Lian, M., Fan, Z., Tian, Y., Wang, Y., Kang, H., Liu, S., Liu, S., Li, T., Shan, Z."Metabolic profiling of hepatitis B virus‑related hepatocellular carcinoma with diverse differentiation grades". Oncology Letters 13, no. 3 (2017): 1204-1210. https://doi.org/10.3892/ol.2017.5596
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