Locally advanced paranasal sinus carcinoma: A study of 30 patients

Perri,Francesco; Addeo,Raffaele; Conson,Manuel; Faiella,Adriana; Scarpati,Giuseppina Della Vittoria; Torre,Gabriella; Di Biase,Angela; Romanelli,Paola; Buonerba,Carlo; Di Lorenzo,Giuseppe; Daponte,Antonio; Caponigro,Francesco; Pisconti,Salvatore; Pacelli,Roberto; Ravo,Vincenzo; Muto,Paolo; Solla,Raffaele

doi:10.3892/ol.2017.5598

March-2017 Volume 13 Issue 3

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

March-2017 Volume 13 Issue 3

Full Size Image

Article

Locally advanced paranasal sinus carcinoma: A study of 30 patients

Authors:
- Francesco Perri
- Raffaele Addeo
- Manuel Conson
- Adriana Faiella
- Giuseppina Della Vittoria Scarpati
- Gabriella Torre
- Angela Di Biase
- Paola Romanelli
- Carlo Buonerba
- Giuseppe Di Lorenzo
- Antonio Daponte
- Francesco Caponigro
- Salvatore Pisconti
- Roberto Pacelli
- Vincenzo Ravo
- Paolo Muto
- Raffaele Solla
View Affiliations / Copyright

Affiliations: Medical Oncology Unit, ‘Santissima Annunziata’ Hospital, I‑74100 Taranto, Italy, Oncology Unit, ‘ASL Napoli 2 Nord’, San Giovanni di Dio Hospital, I‑80027 Naples, Italy, Department of Radiation Therapy, University of Naples ‘Federico II’, I‑80131 Naples, Italy, Oncological Referral Center of Basilicata, The Institute for Research, Hospitalization and Health Care, Rionero in Vulture, I‑85028 Potenza, Italy, Department of Endocrinology and Molecular and Clinical Oncology, University of Naples ‘Federico II’, I‑80131 Naples, Italy, Head and Neck Medical Oncology Unit, National Tumour Institute of Naples,The Institute for Research, Hospitalization and Health Care ‘Fondazione Giovanni Pascale’, I‑80131 Naples, Italy, Department of Radiotherapy, The Foundation Institute for Research, Hospitalization and Health Care ‘Istituto Nazionale dei Tumori’, I‑80131 Naples, Italy, Institute of Biostructure and Bioimaging, National Council of Research, I‑80128 Naples, Italy
Pages: 1338-1342
|
Published online on: January 11, 2017

https://doi.org/10.3892/ol.2017.5598
Expand metrics +

Abstract

Sinonasal carcinomas (SNcs) are rare neoplasms arising from the paranasal sinuses and nasal cavity. Although these tumours have a heterogeneous histology, they are commonly diagnosed as a locally advanced disease and are associated with a poor prognosis. The present retrospective study reviewed 30 patients with locally advanced SNc, who were treated with surgery followed by chemoradiotherapy or radiotherapy, or radiotherapy with or without concomitant chemotherapy between January 1999 and January 2013 at the Department of Radiation Therapy, University of Naples ‘Federico II’ (Naples, Italy). A total of 19 patients were treated with upfront surgery followed by adjuvant radio‑ or chemoradiotherapy (group A), while the remaining 11 patients received exclusive radiotherapy with or without concomitant chemotherapy (group B). Concurrent cisplatin‑based chemotherapy (100 mg/m2, days 1, 22 and 43 for 3 cycles) was administered to 34% of patients in group A and 55% of patients in group B. At a median follow‑up of 31 months, 33.3% of patients were alive. Cause‑specific survival (CSS) and progression‑free survival (PFS) times were 32 and 12 months, respectively. No difference in CSS rate was observed between the two treatment groups. Univariate analysis determined that disease stage was the only factor that significantly affected CSS (P=0.002) and PFS (P=0.0001) rates. Acute and chronic toxicities were mild, with only 23.3% of patients reporting G1‑2 side effects and no treatment‑related blindness. The present study reported moderate activity and efficacy of surgery followed by adjuvant radio‑ or chemoradiotherapy, and exclusive radiotherapy with or without chemotherapy in this poor prognosis category of patients.

View Figures

View References

1	Mahalingappa YB and Khalil HS: Sinonasal malignancy: Presentation and outcomes. J Laryngol Otol. 128:654–657. 2014. View Article : Google Scholar : PubMed/NCBI
2	Dulguerov P, Jacobsen MS, Allal AS, Lehmann W and Calcaterra T: Nasal and paranasal sinus carcinoma: Are we making progress? A series of 220 patients and a systematic review. Cancer. 92:3012–3029. 2001. View Article : Google Scholar : PubMed/NCBI
3	Edge S, Bird D and Compton C: AJCC Cancer Staging Manual. 7th. New York: Springer; 2010
4	Van Eyken E: Cancer incidence in Flanders, 1997–1999VLK. Flemish Cancer Network; Brussels: 2002
5	Périé S, Meyers M, Mazzaschi O, De Crouy Chanel O, Baujat B and St Guily J Lacau: Epidemiology and anatomy of head and neck cancers. Bull Cancer. 101:404–410. 2014.(In French). PubMed/NCBI
6	Katz TS, Mendenhall WM, Morris CG, Amdur RJ, Hinerman RW and Villaret DB: Malignant tumors of the nasal cavity and paranasal sinuses. Head Neck. 24:821–829. 2002. View Article : Google Scholar : PubMed/NCBI
7	Khademi B, Moradi A, Hoseini S and Mohammadianpanah M: Malignant neoplasms of the sinonasal tract: Report of 71 patients and literature review and analysis. Oral Maxillofac Surg. 13:191–199. 2009. View Article : Google Scholar : PubMed/NCBI
8	Dirix P, Nuyts S, Vanstraelen B, Nulens A, Hermans R, Jorissen M, Poorten V Vander and Van den Bogaert W: Post-operative intensity-modulated radiotherapy for malignancies of the nasal cavity and paranasal sinuses. Radiother Oncol. 85:385–391. 2007. View Article : Google Scholar : PubMed/NCBI
9	Hanna E, DeMonte F, Ibrahim S, Roberts D, Levine N and Kupferman M: Endoscopic resection of sinonasal cancers with and without craniotomy: Oncologic results. Arch Otolaryngol Head Neck Surg. 135:1219–1224. 2009. View Article : Google Scholar : PubMed/NCBI
10	Blanco AI, Chao KS, Ozyigit G, Adli M, Thorstad WL, Simpson JR, Spector GJ, Haughey B and Perez CA: Carcinoma of paranasal sinuses: Long-term outcomes with radiotherapy. Int J Radiat Oncol Biol Phys. 59:51–58. 2004. View Article : Google Scholar : PubMed/NCBI
11	Hoffman TK: Systemic therapy strategies for head and neck carcinomas: Current status. GMS Curr Top Otorhinolaryngol Head Neck Surg. 11:Doc032012.PubMed/NCBI
12	Kazi M, Awan S, Junaid M, Qadeer S and Hassan NH: Management of sinonasal tumors: Prognostic factors and outcomes: A 10 year experience at a tertiary care hospital. Indian J Otolaryngol Head Neck Surg. 65:(Suppl 1). S155–S159. 2013. View Article : Google Scholar
13	Harvey RJ and Dalgorf DM: Chapter 10: Sinonasal malignancies. Am J Rhinol Allergy. 27:(Suppl 1). S35–S38. 2013. View Article : Google Scholar : PubMed/NCBI
14	Smith SP, Russell JL, Chen NW, Kuo YF and Resto VA: Sinonasal carcinoma: Racial and ethnic disparities in survival-a review of 4,714 patients. Otolaryngol Head Neck Surg. 153:551–560. 2015. View Article : Google Scholar : PubMed/NCBI
15	Enepekides DJ: Sinonasal undifferentiated carcinoma: An update. Curr Opin Otolaryngol Head Neck Surg. 13:222–225. 2005. View Article : Google Scholar : PubMed/NCBI
16	Dirix P, Vanstraelen B, Jorissen M, Poorten V Vander and Nuyts S: Intensity-modulated radiotherapy for sinonasal cancer: Improved outcome compared to conventional radiotherapy. Int J Radiat Oncol Biol Phys. 78:998–1004. 2010. View Article : Google Scholar : PubMed/NCBI
17	Shukovsky LJ and Fletcher GH: Retinal and optic nerve complications in a high dose irradiation technique of ethmoid sinus and nasal cavity. Radiology. 104:629–634. 1972. View Article : Google Scholar : PubMed/NCBI
18	Ellingwood K and Million R: Cancer of the nasal cavity and ethmoid/sphenoid sinuses. Cancer. 43:1517–1526. 1979. View Article : Google Scholar : PubMed/NCBI
19	Katz TS, Mendenhall WM, Morris CG, Amdur RJ, Hinerman RW and Villaret DB: Malignant tumors of the nasal cavity and paranasal sinuses. Head Neck. 24:821–829. 2002. View Article : Google Scholar : PubMed/NCBI
20	Jacobs C, Lyman G, Velez-García E, Sridhar KS, Knight W, Hochster H, Goodnough LT, Mortimer JE, Einhorn LH, Schacter L, et al: A phase III randomized study comparing cisplatin and fluorouracil as single agents and in combination for advanced squamous cell carcinoma of the head and neck. J Clin Oncol. 10:257–263. 1992.PubMed/NCBI
21	Okano S, Tahara M, Zenda S, Fuse N, Yoshino T, Doi T, Kawashima M, Ogino T, Hayashi R and Ohtsu A: Induction chemotherapy with docetaxel, cisplatin and S-1 followed by proton beam therapy concurrent with cisplatin in patients with T4b nasal and sinonasal malignancies. Jpn J Clin Oncol. 42:691–696. 2012. View Article : Google Scholar : PubMed/NCBI
22	Caponigro F, Longo F, Perri F and Ionna F: Docetaxel in the management of head and neck cancer. Anticancer Drugs. 20:639–645. 2009. View Article : Google Scholar : PubMed/NCBI
23	Burtness B, Goldwasser MA, Flood W, Mattar B and Forastiere AA: Eastern Cooperative Oncology Group: Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: An eastern cooperative oncology group study. J Clin Oncol. 23:8646–8654. 2005. View Article : Google Scholar : PubMed/NCBI
24	National Comprehensive Cancer Network (NCCN), . NCCN Clinical Practice Guidelines in Oncology. https://www.nccn.org/professionals/physician_gls/f_guidelines.asp#siteAccessed. January 21–2016.
25	Cox JD, Stetz J and Pajak TF: Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol Biol Phys. 31:1341–1346. 1995. View Article : Google Scholar : PubMed/NCBI
26	National Comprehensive Cancer Network (NCCN), . Head and Neck Cancers. Version 1.2015. https://www.nccn.org/professionals/physician_gls/pdf/head-and-neck.pdfAccessed. January 21–2016.
27	Sakata K, Maeda A, Rikimaru H, Ono T, Koga N, Takeshige N, Tokutomi T, Umeno H, Kiyokawa K and Morioka M: Advantage of extended craniofacial resection for advanced malignant tumors of the nasal cavity and paranasal sinuses: Long-term outcome and surgical management. World Neurosurg. 89:240–254. 2016. View Article : Google Scholar : PubMed/NCBI
28	Ansa B, Goodman M, Ward K, Kono SA, Owonikoko TK, Higgins K, Beitler JJ, Grist W, Wadsworth T, El-Deiry M, et al: Paranasal sinus squamous cell carcinoma incidence and survival based on Surveillance, Epidemiology, and End Results data, 1973 to 2009. Cancer. 119:2602–2610. 2013. View Article : Google Scholar : PubMed/NCBI
29	Lopez F, Suárez V, Vivanco B, Suárez C and Llorente JL: Current management of sinonasal undifferentiated carcinoma. Rhinology. 53:212–220. 2015.PubMed/NCBI
30	Hoppe BS, Nelson CJ, Gomez DR, Stegman LD, Wu AJ, Wolden SL, Pfister DG, Zelefsky MJ, Shah JP, Kraus DH and Lee NY: Unresectable carcinoma of the paranasal sinuses: Outcomes and toxicities. Int J Radiat Oncol Biol Phys. 72:763–769. 2008. View Article : Google Scholar : PubMed/NCBI
31	Budihna M and Smid L: Carcinoma of the paranasal sinuses: Results of treatment and some prognostic factors. Strahlenther Onkol. 168:322–327. 1992.PubMed/NCBI
32	Bossi P, Saba NF, Vermorken JB, Strojan P, Pala L, de Bree R, Rodrigo JP, Lopez F, Hanna EY, Haigentz M, et al: The role of systemic therapy in the management of sinonasal cancer: A critical review. Cancer Treat Rev. 41:836–843. 2015. View Article : Google Scholar : PubMed/NCBI
33	Stasikowska-Kanicka O, Wagrowska-Danilewicz M and Danilewicz M: Immunohistochemical study on survivin in sinonasal tumors and its relationship with the immunoexpression of Ki67 and Bcl-2. Folia Histochem Cytobiol. 51:225–231. 2013. View Article : Google Scholar : PubMed/NCBI
34	Takahashi Y, Bell D, Agarwal G, Roberts D, Xie TX, El-Naggar A, Myers JN and Hanna EY: Comprehensive assessment of prognostic markers for sinonasal squamous cell carcinoma. Head Neck. 36:1094–1102. 2014. View Article : Google Scholar : PubMed/NCBI
35	Michel J, Fakhry N, Mancini J, Braustein D, Moreddu E, Giovanni A and Dessi P: Sinonasal squamous cell carcinomas: Clinical outcomes and predictive factors. Int J Oral Maxillofac Surg. 43:1–6. 2014. View Article : Google Scholar : PubMed/NCBI
36	Devaraja K, Sikka K, Kumar R and Thakar A: Sinonasal malignancies: Long term follow up after surgical management-an analysis of outcomes. Indian J Otolaryngol Head Neck Surg. 67:28–33. 2015. View Article : Google Scholar : PubMed/NCBI
37	Levine PA, Frierson HF Jr, Stewart FM, Mills SE, Fechner RE and Cantrell RW: Sinonasal undifferentiated carcinoma: A distinctive and highly aggressive neoplasm. Laryngoscope. 97:905–908. 1987. View Article : Google Scholar : PubMed/NCBI
38	Deutsch BD, Levine PA, Stewart FM, Frierson HF Jr and Cantrell RW: Sinonasal undifferentiated carcinoma: A ray of hope. Otolaryngol Head Neck Surg. 108:697–700. 1993. View Article : Google Scholar : PubMed/NCBI