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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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March-2017 Volume 13 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Article

Expression and prognostic value of matriptase in ovarian serous adenocarcinoma

  • Authors:
    • Mei Ji
    • Shunshuang Li
    • Ya Xie
    • Zhao Zhao
    • Weizhong Chang
    • Yue Li
    • Xinghan Cheng
    • Zhuo Wang
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
  • Pages: 1741-1744
    |
    Published online on: January 17, 2017
       https://doi.org/10.3892/ol.2017.5600
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Abstract

Previous studies have demonstrated that matriptase is involved in degradation of the extracellular matrix and angiogenesis, and is overexpressed in certain forms of epithelial cancer. The present study aimed to examine matriptase expression in ovarian serous adenocarcinoma, and to investigate its association with clinicopathological characteristics and patient prognosis. Matriptase expression was analyzed in 80 ovarian serous adenocarcinoma and 12 normal ovarian tissue samples by immunohistochemistry. All data were analyzed to evaluate the association between matriptase expression and clinicopathological parameters and overall survival. Immunohistochemistry demonstrated that matriptase protein was significantly overexpressed in the ovarian serous adenocarcinoma tissues compared with the normal ovarian tissues (P=0.0003). Furthermore, matriptase expression was significantly associated with clinical stage (P=0.0077) and lymph node metastasis (P=0.0111). Kaplan‑Meier survival curves demonstrated that patients with positive matriptase expression had significantly greater survival times (P=0.0008). Matriptase expression is associated with early stage and a greater survival time; therefore, this protein may function as a novel diagnostic and prognostic marker.
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Copy and paste a formatted citation
Spandidos Publications style
Ji M, Li S, Xie Y, Zhao Z, Chang W, Li Y, Cheng X and Wang Z: Expression and prognostic value of matriptase in ovarian serous adenocarcinoma. Oncol Lett 13: 1741-1744, 2017.
APA
Ji, M., Li, S., Xie, Y., Zhao, Z., Chang, W., Li, Y. ... Wang, Z. (2017). Expression and prognostic value of matriptase in ovarian serous adenocarcinoma. Oncology Letters, 13, 1741-1744. https://doi.org/10.3892/ol.2017.5600
MLA
Ji, M., Li, S., Xie, Y., Zhao, Z., Chang, W., Li, Y., Cheng, X., Wang, Z."Expression and prognostic value of matriptase in ovarian serous adenocarcinoma". Oncology Letters 13.3 (2017): 1741-1744.
Chicago
Ji, M., Li, S., Xie, Y., Zhao, Z., Chang, W., Li, Y., Cheng, X., Wang, Z."Expression and prognostic value of matriptase in ovarian serous adenocarcinoma". Oncology Letters 13, no. 3 (2017): 1741-1744. https://doi.org/10.3892/ol.2017.5600
Copy and paste a formatted citation
x
Spandidos Publications style
Ji M, Li S, Xie Y, Zhao Z, Chang W, Li Y, Cheng X and Wang Z: Expression and prognostic value of matriptase in ovarian serous adenocarcinoma. Oncol Lett 13: 1741-1744, 2017.
APA
Ji, M., Li, S., Xie, Y., Zhao, Z., Chang, W., Li, Y. ... Wang, Z. (2017). Expression and prognostic value of matriptase in ovarian serous adenocarcinoma. Oncology Letters, 13, 1741-1744. https://doi.org/10.3892/ol.2017.5600
MLA
Ji, M., Li, S., Xie, Y., Zhao, Z., Chang, W., Li, Y., Cheng, X., Wang, Z."Expression and prognostic value of matriptase in ovarian serous adenocarcinoma". Oncology Letters 13.3 (2017): 1741-1744.
Chicago
Ji, M., Li, S., Xie, Y., Zhao, Z., Chang, W., Li, Y., Cheng, X., Wang, Z."Expression and prognostic value of matriptase in ovarian serous adenocarcinoma". Oncology Letters 13, no. 3 (2017): 1741-1744. https://doi.org/10.3892/ol.2017.5600
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