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Article

TRIM24 promotes the aggression of gastric cancer via the Wnt/β‑catenin signaling pathway

  • Authors:
    • Ziling Fang
    • Jun Deng
    • Ling Zhang
    • Xiaojun Xiang
    • Feng Yu
    • Jun Chen
    • Miao Feng
    • Jianping Xiong
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China
  • Pages: 1797-1806
    |
    Published online on: January 17, 2017
       https://doi.org/10.3892/ol.2017.5604
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Abstract

Tripartite motif-containing 24 (TRIM24) is important in tumor development and progression. However, the role of TRIM24 in gastric cancer (GC) and the mechanisms underlying the dysregulated expression of TRIM24 remain to be fully elucidated. In the present study, it was found that TRIM24 was frequently overexpressed in GC cell lines and tissues compared with normal controls, as determined by western blotting and immunohistochemical staining. The high nuclear expression of TRIM24 was correlated with the depth of invasion (P=0.007), tumor‑node‑metastasis stage (P=0.005), and lymph node metastasis (P=0.027), and shorter overall survival rates (P=0.010) in patients with GC. Small interfering RNA‑mediated knockdown of TRIM24 inhibited cell proliferation, colony formation, migration, invasion and the nuclear accumulation of β‑catenin, and it delayed cell cycle progression and induced apoptosis. In addition, the expression of TRIM24 was positively correlated with that of β‑catenin in GC tissues. TRIM24 knockdown decreased the expression of Wnt/β‑catenin target genes, whereas the activation of Wnt/β‑catenin signaling by lithium chloride reversed the effects of TRIM24 knockdown. Taken together, these data suggested that TRIM24 was a prognostic or potential therapeutic target for patients with GC and was important in the activation of the Wnt/β‑catenin pathway during the progression of GC.
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View References

1 

Siegel R, Desantis C and Jemal A: Colorectal cancer statistics, 2014. CA Cancer J Clin. 64:104–117. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Clevers H and Nusse R: Wnt/beta-catenin signaling and disease. Cell. 149:1192–1205. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Behrens J, Jerchow BA, Würtele M, Grimm J, Asbrand C, Wirtz R, Kühl M, Wedlich D and Birchmeier W: Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta. Science. 280:596–599. 1998. View Article : Google Scholar : PubMed/NCBI

4 

Ikeda S, Kishida S, Yamamoto H, Murai H, Koyama S and Kikuchi A: Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin. EMBO J. 17:1371–1384. 1998. View Article : Google Scholar : PubMed/NCBI

5 

Ogasawara N, Tsukamoto T, Mizoshita T, Inada K, Cao X, Takenaka Y, Joh T and Tatematsu M: Mutations and nuclear accumulation of beta-catenin correlate with intestinal phenotypic expression in human gastric cancer. Histopathology. 49:612–621. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Klaus A and Birchmeier W: Wnt signaling and its impact on development and cancer. Nat Rev Cancer. 8:387–398. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Clevers H: Wnt/β-catenin signaling in development and disease. Cell. 127:469–480. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Liu W, Dong X, Mai M, Seelan RS, Taniquchi K, Krishnadath KK, Halling KC, Cunningham JM, Boardman LA, Qian C, Christensen E, Schmidt SS, Roche PC, Smith DI and Thibodeau SN: Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signaling. Nat Genet. 26:5012000. View Article : Google Scholar : PubMed/NCBI

9 

Hatakeyama S: TRIM proteins and cancer. Nat Rev Cancer. 11:792–804. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Herquel B, Ouararhni K and Davidson I: The TIF1α-related TRIM cofactors couple chromatin modifications to transcriptional regulation, signaling and tumor suppression. Transcription. 2:231–236. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Allton K, Jain AK, Herz HM, Tsai WW, Jung SY, Qin J, Bergmann A, Johnson RL and Barton MC: Trim24 targets endogenous p53 for degradation. Proc Natl Acad Sci USA. 106:11612–11616. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Jain AK and Barton MC: Regulation of p53: TRIM24 enters the RING. Cell Cycle. 8:3668–3674. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Tsai WW, Wang Z, Yiu TT, Tsai WW, Jung SY, Qin J, Bergmann A, Johnson RL, Barton MC, Aronow B, et al: TRIM24 links a non-canonical histone signature to breast cancer. Nature. 468:927–932. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Pathiraja TN, Thakkar KN, Jiang S, Stratton S, Liu Z, Gagea M, Shi X, Shah PK, Phan L, Lee MH, et al: TRIM24 links glucose metabolism with transformation of human mammary epithelial cells. Oncogene. 34:2836–2845. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Zhong S, Delva L, Rachez C, Cenciarelli C, Gandini D, Zhang H, Kalantry S, Freedman LP, Pandolfi PP, et al: A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins. Nat Genet. 23:287–295. 1999. View Article : Google Scholar : PubMed/NCBI

16 

Belloni E, Trubia M, Gasparini P, Micucci C, Tapinassi C, Confalonieri S, Nuciforo P, Martino B, Lo-Coco F, Pelicci PG and Di Fiore PP: 8p11 myeloproliferative syndrome with a novel t(7;8) translocation leading to fusion of the FGFR1 and TIF1 genes. Genes Chromosomes Cancer. 42:320–325. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Klugbauer S and Rabes HM: The transcription coactivator HTIF1 and a related protein are fused to the RET receptor tyrosine kinase in childhood papillary thyroid carcinomas. Oncogene. 18:4388–4393. 1999. View Article : Google Scholar : PubMed/NCBI

18 

Wang L, Heidt DG, Lee CJ, Yang H, Logsdon CD, Zhang L, Fearon ER, Ljungman M and Simeone DM: Oncogenic function of ATDC in pancreatic cancer through Wnt pathway activation and beta-catenin stabilization. Cancer Cell. 15:207–219. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Liu X, Huang Y, Yang D, Li X, Liang J, Lin L, Zhang M, Zhong K, Liang B and Li J: Overexpression of TRIM24 is associated with the onset and progress of human hepatocellular carcinoma. PloS One. 9:e854622014. View Article : Google Scholar : PubMed/NCBI

20 

Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL and Trotti A: AJCC Cancer Staging Manual. Springer; New York, NY: 2010

21 

Bosman FT, Carneiro F, Hruban RH and Theise ND: WHO Classification of Tumours of the Digestive System. 4th. IARC Press; Lyon: 2010

22 

Pan X, Zhou T, Tai YH, Wang C, Zhao J, Cao Y, Chen Y, Zhang PJ, Yu M, Zhen C, et al: Elevated expression of CUEDC2 protein confers endocrine resistance in breast cancer. Nat Med. 17:708–714. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Wu WK, Cho CH, Lee CW, Fan D, Wu K, Yu J and Sung JJ: Dysregulation of cellular signaling in gastric cancer. Cancer Lett. 295:144–153. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Chambon M, Orsetti B, Berthe ML, Bascoul-Mollevi C, Rodriguez C, Duong V, Gleizes M, Thénot S, Bibeau F, Theillet C and Cavaillès V: Prognostic significance of TRIM24/TIF-1α gene expression in breast cancer. Am J Pathol. 178:1461–1469. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Cui Z, Cao W, Li J, Song X, Mao L and Chen W: TRIM24 overexpression is common in locally advanced head and neck squamous cell carcinoma and correlates with aggressive malignant phenotypes. PloS One. 8:e638872013. View Article : Google Scholar : PubMed/NCBI

27 

Zhang LH, Yin AA, Cheng JX, Huang HY, Li XM, Zhang YQ, Han N and Zhang X: TRIM24 promotes glioma progression and enhances chemoresistance through activation of the PI3K/Akt signaling pathway. Oncogene. 34:600–610. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Li H, Sun L, Tang Z, Fu L, Xu Y, Li Z, Luo W, Qiu X and Wang E: Overexpression of TRIM24 correlates with tumor progression in non-small cell lung cancer. PloS One. 7:e376572012. View Article : Google Scholar : PubMed/NCBI

29 

Xue D, Zhang X, Liu J, Liu J, Li N, Liu C, Liu Y and Wang P: Clinical significance and biological roles of TRIM24 in human bladder carcinoma. Tumour Biol. 36:6849–6855. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Wang J, Zhu J, Dong M, Yu H, Dai X and Li K: Knockdown of tripartite motif containing 24 by lentivirus suppresses cell growth and induces apoptosis in human colorectal cancer cells. Oncol Res. 22:39–45. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Jain AK, Allton K, Duncan AD and Barton MC: TRIM24 is a p53-induced E3-ubiquitin ligase that undergoes ATM-mediated phosphorylation and autodegradation during DNA damage. Mol Cell Biol. 34:2695–2709. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Knudsen KE, Diehl JA, Haiman CA and Knudsen ES: Cyclin D1: Polymorphism, aberrant splicing and cancer risk. Oncogene. 25:1620–1628. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Roy PG and Thompson AM: Cyclin D1 and breast cancer. Breast. 15:718–727. 2006. View Article : Google Scholar : PubMed/NCBI

34 

Kishimoto I, Mitomi H, Ohkura Y, Kanazawa H, Fukui N and Watanabe M: Abnormal expression of p16 (INK4a), cyclin D1, cyclin-dependent kinase 4 and retinoblastoma protein in gastric carcinomas. J Surg Oncol. 98:60–66. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Niu Z, Liu H, Zhou M, Wang H, Liu Y, Li X, Xiong W, Ma J, Li X and Li G: Knockdown of c-Myc inhibits cell proliferation by negatively regulating the Cdk/Rb/E2F pathway in nasopharyngeal carcinoma cells. Acta Biochim Biophys Sin (Shanghai). 47:183–191. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Kalluri R and Weinberg RA: The basics of epithelial-mesenchymal transition. J Clin Invest. 119:1420–1428. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Howard S, Deroo T, Fujita Y and Itasaki N: A positive role of cadherin in Wnt/β-catenin signalling during epithelial-mesenchymal transition. PloS One. 6:e238992011. View Article : Google Scholar : PubMed/NCBI

38 

Huber MA, Kraut N and Beug H: Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr Opin Cell Biol. 17:548–558. 2005. View Article : Google Scholar : PubMed/NCBI

39 

Polette M, Mestdagt M, Bindels S, Nawrocki-Raby B, Hunziker W, Foidart JM, Birembaut P and Gilles C: Beta-catenin and ZO-1: Shuttle molecules involved in tumor invasion-associated epithelial-mesenchymal transition processes. Cells Tissues Organs. 185:61–65. 2007. View Article : Google Scholar : PubMed/NCBI

40 

Valenta T, Hausmann G and Basler K: The many faces and functions of β-catenin. EMBO J. 31:2714–2736. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Miyazawa K, Iwaya K, Kuroda M, Harada M, Serizawa H, Koyanagi Y, Sato Y, Mizokami Y, Matsuoka T and Mukai K: Nuclear accumulation of beta-catenin in intestinal-type gastric carcinoma: Correlation with early tumor invasion. Virchows Arch. 437:508–513. 2000. View Article : Google Scholar : PubMed/NCBI

42 

Chiu CG, Chan SK, Fang ZA, Masoudi H, Wood-Baker R, Jones SJ, Gilks B, Laskin J and Wiseman SM: Beta-catenin expression is prognostic of improved non-small cell lung cancer survival. Am J Surg. 203:654–659. 2012. View Article : Google Scholar : PubMed/NCBI

43 

Miao ZF, Wang ZN, Zhao TT, Xu YY, Wu JH, Liu XY, Xu H, You Y and Xu HM: TRIM24 is upregulated in human gastric cancer and promotes gastric cancer cell growth and chemoresistance. Virchows Arch. 466:525–532. 2015. View Article : Google Scholar : PubMed/NCBI

44 

MacDonald BT, Tamai K and He X: Wnt/beta-catenin signaling: Components, mechanisms and diseases. Dev Cell. 17:9–26. 2009. View Article : Google Scholar : PubMed/NCBI

45 

Ying Y and Tao Q: Epigenetic disruption of the WNT/beta-catenin signaling pathway in human cancers. Epigenetics. 4:307–312. 2009. View Article : Google Scholar

46 

Liu Y, Huang T, Zhao X and Cheng L: MicroRNAs modulate the Wnt signaling pathway through targeting its inhibitors. Biochem Biophys Res Commun. 408:259–264. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Fang Z, Deng J, Zhang L, Xiang X, Yu F, Chen J, Feng M and Xiong J: TRIM24 promotes the aggression of gastric cancer via the Wnt/β‑catenin signaling pathway. Oncol Lett 13: 1797-1806, 2017.
APA
Fang, Z., Deng, J., Zhang, L., Xiang, X., Yu, F., Chen, J. ... Xiong, J. (2017). TRIM24 promotes the aggression of gastric cancer via the Wnt/β‑catenin signaling pathway. Oncology Letters, 13, 1797-1806. https://doi.org/10.3892/ol.2017.5604
MLA
Fang, Z., Deng, J., Zhang, L., Xiang, X., Yu, F., Chen, J., Feng, M., Xiong, J."TRIM24 promotes the aggression of gastric cancer via the Wnt/β‑catenin signaling pathway". Oncology Letters 13.3 (2017): 1797-1806.
Chicago
Fang, Z., Deng, J., Zhang, L., Xiang, X., Yu, F., Chen, J., Feng, M., Xiong, J."TRIM24 promotes the aggression of gastric cancer via the Wnt/β‑catenin signaling pathway". Oncology Letters 13, no. 3 (2017): 1797-1806. https://doi.org/10.3892/ol.2017.5604
Copy and paste a formatted citation
x
Spandidos Publications style
Fang Z, Deng J, Zhang L, Xiang X, Yu F, Chen J, Feng M and Xiong J: TRIM24 promotes the aggression of gastric cancer via the Wnt/β‑catenin signaling pathway. Oncol Lett 13: 1797-1806, 2017.
APA
Fang, Z., Deng, J., Zhang, L., Xiang, X., Yu, F., Chen, J. ... Xiong, J. (2017). TRIM24 promotes the aggression of gastric cancer via the Wnt/β‑catenin signaling pathway. Oncology Letters, 13, 1797-1806. https://doi.org/10.3892/ol.2017.5604
MLA
Fang, Z., Deng, J., Zhang, L., Xiang, X., Yu, F., Chen, J., Feng, M., Xiong, J."TRIM24 promotes the aggression of gastric cancer via the Wnt/β‑catenin signaling pathway". Oncology Letters 13.3 (2017): 1797-1806.
Chicago
Fang, Z., Deng, J., Zhang, L., Xiang, X., Yu, F., Chen, J., Feng, M., Xiong, J."TRIM24 promotes the aggression of gastric cancer via the Wnt/β‑catenin signaling pathway". Oncology Letters 13, no. 3 (2017): 1797-1806. https://doi.org/10.3892/ol.2017.5604
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