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Review

Current status of the prognostic molecular biomarkers in breast cancer: A systematic review (Review)

  • Authors:
    • Goro Kutomi
    • Toru Mizuguchi
    • Fukino Satomi
    • Hideki Maeda
    • Hiroaki Shima
    • Yasutoshi Kimura
    • Koichi Hirata
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Surgical Oncology and Science, Sapporo Medical University, Sapporo, Hokkaido 060‑8543, Japan
  • Pages: 1491-1498
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    Published online on: January 17, 2017
       https://doi.org/10.3892/ol.2017.5609
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Abstract

Biomarkers that facilitate the prediction of breast cancer prognosis can improve the quality of life in patients during the long period of illness and treatment. Particularly in recent years, with the advent of a more exhaustive analysis of genetic information and gene products, the molecular mechanisms at play during breast cancer have gradually become clearer. In the present study, a systematic review of the literature between 2009 and 2014 was conducted by searching for the keywords ʻbreast cancerʼ, ʻbiomarkersʼ, ʻdiagnosisʼ, ʻprognosisʼ and ʻdrug responseʼ to clarify the present state of knowledge regarding biomarkers. In the final analysis, 16 studies on biomarkers for the breast cancer prognosis were retrieved. From these, 7 biomarkers in 9 studies were found to be strongly reliable predictors of prognosis and a further 7 biomarkers in 7 studies were poorly reliable. The use of these prognostic biomarkers should increase the options available for treatment algorithms.
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Copy and paste a formatted citation
Spandidos Publications style
Kutomi G, Mizuguchi T, Satomi F, Maeda H, Shima H, Kimura Y and Hirata K: Current status of the prognostic molecular biomarkers in breast cancer: A systematic review (Review). Oncol Lett 13: 1491-1498, 2017.
APA
Kutomi, G., Mizuguchi, T., Satomi, F., Maeda, H., Shima, H., Kimura, Y., & Hirata, K. (2017). Current status of the prognostic molecular biomarkers in breast cancer: A systematic review (Review). Oncology Letters, 13, 1491-1498. https://doi.org/10.3892/ol.2017.5609
MLA
Kutomi, G., Mizuguchi, T., Satomi, F., Maeda, H., Shima, H., Kimura, Y., Hirata, K."Current status of the prognostic molecular biomarkers in breast cancer: A systematic review (Review)". Oncology Letters 13.3 (2017): 1491-1498.
Chicago
Kutomi, G., Mizuguchi, T., Satomi, F., Maeda, H., Shima, H., Kimura, Y., Hirata, K."Current status of the prognostic molecular biomarkers in breast cancer: A systematic review (Review)". Oncology Letters 13, no. 3 (2017): 1491-1498. https://doi.org/10.3892/ol.2017.5609
Copy and paste a formatted citation
x
Spandidos Publications style
Kutomi G, Mizuguchi T, Satomi F, Maeda H, Shima H, Kimura Y and Hirata K: Current status of the prognostic molecular biomarkers in breast cancer: A systematic review (Review). Oncol Lett 13: 1491-1498, 2017.
APA
Kutomi, G., Mizuguchi, T., Satomi, F., Maeda, H., Shima, H., Kimura, Y., & Hirata, K. (2017). Current status of the prognostic molecular biomarkers in breast cancer: A systematic review (Review). Oncology Letters, 13, 1491-1498. https://doi.org/10.3892/ol.2017.5609
MLA
Kutomi, G., Mizuguchi, T., Satomi, F., Maeda, H., Shima, H., Kimura, Y., Hirata, K."Current status of the prognostic molecular biomarkers in breast cancer: A systematic review (Review)". Oncology Letters 13.3 (2017): 1491-1498.
Chicago
Kutomi, G., Mizuguchi, T., Satomi, F., Maeda, H., Shima, H., Kimura, Y., Hirata, K."Current status of the prognostic molecular biomarkers in breast cancer: A systematic review (Review)". Oncology Letters 13, no. 3 (2017): 1491-1498. https://doi.org/10.3892/ol.2017.5609
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