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Article

Zoledronic acid reverses cisplatin resistance in nasopharyngeal carcinoma cells by activating the mitochondrial apoptotic pathway

  • Authors:
    • Yanjie You
    • Haijun Li
    • Jiongyu Chen
    • Xin Qin
    • Yonggang Ran
  • View Affiliations / Copyright

    Affiliations: Pathological Examination and Research Center, Luohe Medical College, Luohe, Henan 462002, P.R. China, Department of Radiation Oncology, The Second People's Hospital of Neijiang, Neijiang, Sichuan 641000, P.R. China, Department of Laboratory, Cancer Hospital of Shantou University, Shantou, Guangdong 515041, P.R. China, Medical College, Hubei University of Arts and Science, Xiangyang, Hubei 441053, P.R. China, Department of Teaching and Training, Bethune Military Medical NCO Academy of PLA, Shijiazhuang, Hebei 050081, P.R. China
  • Pages: 1840-1846
    |
    Published online on: January 18, 2017
       https://doi.org/10.3892/ol.2017.5611
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Abstract

Despite improvements to radiotherapeutic strategies, resistance to adjuvant chemotherapy remains the main problem underlying the low 5‑year survival rate in patients with nasopharyngeal carcinoma (NPC). In the present study, the human NPC cell line HNE1 was exposed to gradually increasing concentrations of cisplatin (CDDP) in order to establish a drug‑resistant sub‑cell line, HNE1/CDDP. HNE1/CDDP cells exhibited multidrug resistance and a prolonged doubling time, as compared with the parent HNE1 cells. Furthermore, pretreatment with zoledronic acid (ZOL) appeared to resensitize the CDDP‑resistant cells by inducing S‑phase cell cycle arrest and the mitochondrial apoptotic pathway by upregulating the expression of B‑cell lymphoma‑2 (BCL‑2)‑associated X protein and caspase‑9 and downregulating the expression of BCL‑2. The results of the present study suggested that HNE1/CDDP cells are a stable, multidrug‑resistant NPC cell line that may serve as an important tool for research in drug resistance. In addition, the application of ZOL may hold clinical therapeutic potential for the treatment of drug resistance in NPC.
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Copy and paste a formatted citation
Spandidos Publications style
You Y, Li H, Chen J, Qin X and Ran Y: Zoledronic acid reverses cisplatin resistance in nasopharyngeal carcinoma cells by activating the mitochondrial apoptotic pathway. Oncol Lett 13: 1840-1846, 2017.
APA
You, Y., Li, H., Chen, J., Qin, X., & Ran, Y. (2017). Zoledronic acid reverses cisplatin resistance in nasopharyngeal carcinoma cells by activating the mitochondrial apoptotic pathway. Oncology Letters, 13, 1840-1846. https://doi.org/10.3892/ol.2017.5611
MLA
You, Y., Li, H., Chen, J., Qin, X., Ran, Y."Zoledronic acid reverses cisplatin resistance in nasopharyngeal carcinoma cells by activating the mitochondrial apoptotic pathway". Oncology Letters 13.3 (2017): 1840-1846.
Chicago
You, Y., Li, H., Chen, J., Qin, X., Ran, Y."Zoledronic acid reverses cisplatin resistance in nasopharyngeal carcinoma cells by activating the mitochondrial apoptotic pathway". Oncology Letters 13, no. 3 (2017): 1840-1846. https://doi.org/10.3892/ol.2017.5611
Copy and paste a formatted citation
x
Spandidos Publications style
You Y, Li H, Chen J, Qin X and Ran Y: Zoledronic acid reverses cisplatin resistance in nasopharyngeal carcinoma cells by activating the mitochondrial apoptotic pathway. Oncol Lett 13: 1840-1846, 2017.
APA
You, Y., Li, H., Chen, J., Qin, X., & Ran, Y. (2017). Zoledronic acid reverses cisplatin resistance in nasopharyngeal carcinoma cells by activating the mitochondrial apoptotic pathway. Oncology Letters, 13, 1840-1846. https://doi.org/10.3892/ol.2017.5611
MLA
You, Y., Li, H., Chen, J., Qin, X., Ran, Y."Zoledronic acid reverses cisplatin resistance in nasopharyngeal carcinoma cells by activating the mitochondrial apoptotic pathway". Oncology Letters 13.3 (2017): 1840-1846.
Chicago
You, Y., Li, H., Chen, J., Qin, X., Ran, Y."Zoledronic acid reverses cisplatin resistance in nasopharyngeal carcinoma cells by activating the mitochondrial apoptotic pathway". Oncology Letters 13, no. 3 (2017): 1840-1846. https://doi.org/10.3892/ol.2017.5611
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