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Article

MicroRNA‑29a/b/c targets iNOS and is involved in protective remote ischemic preconditioning in an ischemia‑reperfusion rat model of non‑alcoholic fatty liver disease

  • Authors:
    • Yun‑Fei Duan
    • Dong‑Lin Sun
    • Jing Chen
    • Feng Zhu
    • Yong An
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu 213000, P.R. China
  • Pages: 1775-1782
    |
    Published online on: January 18, 2017
       https://doi.org/10.3892/ol.2017.5623
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Abstract

Remote ischemic preconditioning (RIPC) protects against the injury that is incurred by ischemia and reperfusion (IR); however, the role of RIPC in liver IR injury in non‑alcoholic fatty liver disease (NAFLD) remains unclear. In this study, a NAFLD rat model was utilized in a series of different surgical procedures and molecular experiments. Rats of the IR group and the RIPC+IR group exhibited more severe injury than NAFLD control rats (in which the liver was prodded following a median‑incision laparotomy). The liver condition, measured by serum alanine transaminase and aspartate transaminase levels, of the RIPC+IR group was better than that of the IR group. In addition, alanine transaminase and aspartate transaminase levels were lower in the RIPC+IR group compared with the IR group (P<0.001). Flow cytometry revealed that the cell apoptosis ratio was significantly lower in the RIPC+IR group than in the IR group (P<0.001). Reverse transcription‑polymerase chain reaction (RT‑qPCR) was used to assess miR‑29a/b/c levels, revealing that they were significantly reduced in the RIPC and RIPC+IR groups, but did not vary in the IR group compared with the control group. RT‑qPCR also revealed that iNOS mRNA levels were not significantly different among any of the NAFLD groups; however, western blot analysis indicated that iNOS protein levels were increased in the RIPC group and the RIPC+IR group compared with the control and IR groups. A luciferase reporter assay demonstrated that transfection with miR‑29a/b/c mimics significantly decreased the luciferase activities of plasmids containing the wild‑type iNOS 3'‑untranslated region (UTR) (relative fluorescence intensity: 0.47±0.06 for miR‑29a, 0.36±0.07 for miR‑29b, 0.41±0.04 for miR‑29c; P<0.001), whereas the activities of plasmids containing the mutant iNOS 3'‑UTR sequence were not markedly affected [relative fluorescence intensity: 0.99±0.08 for miR‑29a (P=0.1349), 0.99±0.09 for miR‑29b (P=0.1607), 0.97±0.07 for miR‑29c (P=0.1824)]. This suggested that miR‑29a/b/c downregulates iNOS by directly targeting its 3'‑UTR. In summary, the results suggest that RIPC has a protective effect in NAFLD liver IR injury, which may be due to reduced miR‑29a/b/c levels in the skeletal muscle, leading to increased iNOS and, therefore, nitric oxide.
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1 

Lomonaco R, Sunny NE, Bril F and Cusi K: Nonalcoholic fatty liver disease: Current issues and novel treatment approaches. Drugs. 73:1–14. 2013. View Article : Google Scholar : PubMed/NCBI

2 

de Meijer VE, Kalish BT, Puder M and Ijzermans JN: Systematic review and meta-analysis of steatosis as a risk factor in major hepatic resection. Br J Surg. 97:1331–1339. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Marsman HA, Heger M, Kloek JJ, Nienhuis SL, ten Kate FJ and van Gulik TM: Omega-3 fatty acids reduce hepatic steatosis and consequently attenuate ischemia-reperfusion injury following partial hepatectomy in rats. Dig Liver Dis. 43:984–990. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Song X, Xu H, Feng Y, Li X, Lin M and Cao L: Protective effect of grape seed proanthocyanidins against liver ischemic reperfusion injury: Particularly in diet-induced obese mice. Int J Biol Sci. 8:1345–1362. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Gassanov N, Nia AM, Caglayan E and Er F: Remote ischemic preconditioning and renoprotection: From myth to a novel therapeutic option. J Am Soc Nephrol. 25:216–224. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Manchurov V, Ryazankina N, Khmara T, Skrypnik D, Reztsov R, Vasilieva E and Shpektor A: Remote ischemic preconditioning and endothelial function in patients with acute myocardial infarction and primary PCI. Am J Med. 127:670–673. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Schmidt MR, Støttrup NB, Michelsen MM, Contractor H, Sørensen KE, Kharbanda RK, Redington AN and Bøtker HE: Remote ischemic preconditioning impairs ventricular function and increases infarct size after prolonged ischemia in the isolated neonatal rabbit heart. J Thorac Cardiovasc Surg. 147:1049–1055. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Crimi G, Pica S, Raineri C, Bramucci E, De Ferrari GM, Klersy C, Ferlini M, Marinoni B, Repetto A, Romeo M, et al: Remote ischemic post-conditioning of the lower limb during primary percutaneous coronary intervention safely reduces enzymatic infarct size in anterior myocardial infarction: A randomized controlled trial. JACC Cardiovasc Interv. 6:1055–1063. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Cai ZP, Parajuli N, Zheng X and Becker L: Remote ischemic preconditioning confers late protection against myocardial ischemia-reperfusion injury in mice by upregulating interleukin-10. Basic Res Cardiol. 107:2772012. View Article : Google Scholar : PubMed/NCBI

10 

Wever KE, Warlé MC, Wagener FA, van der Hoorn JW, Masereeuw R, van der Vliet JA and Rongen GA: Remote ischaemic preconditioning by brief hind limb ischaemia protects against renal ischaemia-reperfusion injury: The role of adenosine. Nephrol Dial Transplant. 26:3108–3117. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Dong HL, Zhang Y, Su BX, Zhu ZH, Gu QH, Sang HF and Xiong L: Limb remote ischemic preconditioning protects the spinal cord from ischemia-reperfusion injury: A newly identified nonneuronal but reactive oxygen species-dependent pathway. Anesthesiology. 112:881–891. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Zhou W, Zeng D, Chen R, Liu J, Yang G, Liu P and Zhou X: Limb ischemic preconditioning reduces heart and lung injury after an open heart operation in infants. Pediatr Cardiol. 31:22–29. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Rentoukas I, Giannopoulos G, Kaoukis A, Kossyvakis C, Raisakis K, Driva M, Panagopoulou V, Tsarouchas K, Vavetsi S, Pyrgakis V and Deftereos S: Cardioprotective role of remote ischemic periconditioning in primary percutaneous coronary intervention: Enhancement by opioid action. JACC Cardiovasc Interv. 3:49–55. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Kanoria S, Jalan R, Davies NA, Seifalian AM, Williams R and Davidson BR: Remote ischaemic preconditioning of the hind limb reduces experimental liver warm ischaemia-reperfusion injury. Br J Surg. 93:762–768. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Tapuria N, Junnarkar SP, Dutt N, Abu-Amara M, Fuller B, Seifalian AM and Davidson BR: Effect of remote ischemic preconditioning on hepatic microcirculation and function in a rat model of hepatic ischemia reperfusion injury. HPB (Oxford). 11:108–117. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Wang M, Shen J, Feng B, Gui L, Chen Q, Zhang B, Tang J and Li X: Remote ischemic preconditioning promotes early liver cell proliferation in a rat model of small-for-size liver transplantation. J Surg Res. 179:e245–e253. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Abu-Amara M, Yang SY, Quaglia A, Rowley P, Tapuria N, Seifalian AM, Fuller BJ and Davidson BR: Effect of remote ischemic preconditioning on liver ischemia/reperfusion injury using a new mouse model. Liver Transpl. 17:70–82. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Jensen RV, Zachara NE, Nielsen PH, Kimose HH, Kristiansen SB and Bøtker HE: Impact of O-GlcNAc on cardioprotection by remote ischaemic preconditioning in non-diabetic and diabetic patients. Cardiovasc Res. 97:369–378. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Contractor H, Støttrup NB, Cunnington C, Manlhiot C, Diesch J, Ormerod JO, Jensen R, Bøtker HE, Redington A, Schmidt MR, et al: Aldehyde dehydrogenase-2 inhibition blocks remote preconditioning in experimental and human models. Basic Res Cardiol. 108:3432013. View Article : Google Scholar : PubMed/NCBI

20 

Abu-Amara M, Yang SY, Quaglia A, Rowley P, Tapuria N, Fuller B, Davidson B and Seifalian A: The hepatic soluble guanylyl cyclase-cyclic guanosine monophosphate pathway mediates the protection of remote ischemic preconditioning on the microcirculation in liver ischemia-reperfusion injury. Transplantation. 93:880–886. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Zitta K, Meybohm P, Bein B, Heinrich C, Renner J, Cremer J, Steinfath M, Scholz J and Albrecht M: Serum from patients undergoing remote ischemic preconditioning protects cultured human intestinal cells from hypoxia-induced damage: Involvement of matrixmetalloproteinase-2 and −9. Mol Med. 18:29–37. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Li J, Xuan W, Yan R, Tropak MB, Jean-St-Michel E, Liang W, Gladstone R, Backx PH, Kharbanda RK and Redington AN: Remote preconditioning provides potent cardioprotection via PI3K/Akt activation and is associated with nuclear accumulation of β-catenin. Clin Sci (Lond). 120:451–462. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Kanoria S, Glantzounis G, Quaglia A, Dinesh S, Fusai G, Davidson BR and Seifalian AM: Remote preconditioning improves hepatic oxygenation after ischaemia reperfusion injury. Transpl Int. 25:783–791. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Tapuria N, Junnarkar S, Abu-Amara M, Fuller B, Seifalian AM and Davidson BR: Modulation of microcirculatory changes in the late phase of hepatic ischaemia-reperfusion injury by remote ischaemic preconditioning. HPB (Oxford). 14:87–97. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Abu-Amara M, Yang SY, Quaglia A, Rowley P, de Mel A, Tapuria N, Seifalian A, Davidson B and Fuller B: Nitric oxide is an essential mediator of the protective effects of remote ischaemic preconditioning in a mouse model of liver ischaemia/reperfusion injury. Clin Sci (Lond). 121:257–266. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Michel T and Feron O: Nitric oxide synthases: which, where, how, and why? J Clin Invest. 100:2146–2152. 1997. View Article : Google Scholar : PubMed/NCBI

28 

Alderton WK, Cooper CE and Knowles RG: Nitric oxide synthases: structure, function and inhibition. Biochem J. 357:593–615. 2001. View Article : Google Scholar : PubMed/NCBI

29 

Phillips L, Toledo AH, Lopez-Neblina F, Anaya-Prado R and Toledo-Pereyra LH: Nitric oxide mechanism of protection in ischemia and reperfusion injury. J Invest Surg. 22:46–55. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Jiang H, Zhang G, Wu JH and Jiang CP: Diverse roles of miR-29 in cancer (review). Oncol Rep. 31:1509–1516. 2014.PubMed/NCBI

31 

Galagudza MM, Sonin DL, Vlasov TD, Kurapeev DI and Shlyakhto EV: Remote vs. local ischaemic preconditioning in the rat heart: infarct limitation, suppression of ischaemic arrhythmia and the role of reactive oxygen species. Int J Exp Pathol. 97:66–74. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Totzeck M, Hendgen-Cotta U and Rassaf T: Concepts of hypoxic NO signaling in remote ischemic preconditioning. World J Cardiol. 7:645–651. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Fatemi N, Sanati MH, Shamsara M, Moayer F, Zavarehei MJ, Pouya A, Sayyahpour F, Ayat H and Gourabi H: TBHP-induced oxidative stress alters microRNAs expression in mouse testis. J Assist Reprod Genet. 31:1287–1293. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Wang Z, Liu Y, Han N, Chen X, Yu W, Zhang W and Zou F: Profiles of oxidative stress-related microRNA and mRNA expression in auditory cells. Brain Res. 1346:14–25. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Mathé E, Nguyen GH, Funamizu N, He P, Moake M, Croce CM and Hussain SP: Inflammation regulates microRNA expression in cooperation with p53 and nitric oxide. Int J Cancer. 131:760–765. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Duan YF, Sun DL, Chen J, Zhu F and An Y: MicroRNA‑29a/b/c targets iNOS and is involved in protective remote ischemic preconditioning in an ischemia‑reperfusion rat model of non‑alcoholic fatty liver disease. Oncol Lett 13: 1775-1782, 2017.
APA
Duan, Y., Sun, D., Chen, J., Zhu, F., & An, Y. (2017). MicroRNA‑29a/b/c targets iNOS and is involved in protective remote ischemic preconditioning in an ischemia‑reperfusion rat model of non‑alcoholic fatty liver disease. Oncology Letters, 13, 1775-1782. https://doi.org/10.3892/ol.2017.5623
MLA
Duan, Y., Sun, D., Chen, J., Zhu, F., An, Y."MicroRNA‑29a/b/c targets iNOS and is involved in protective remote ischemic preconditioning in an ischemia‑reperfusion rat model of non‑alcoholic fatty liver disease". Oncology Letters 13.3 (2017): 1775-1782.
Chicago
Duan, Y., Sun, D., Chen, J., Zhu, F., An, Y."MicroRNA‑29a/b/c targets iNOS and is involved in protective remote ischemic preconditioning in an ischemia‑reperfusion rat model of non‑alcoholic fatty liver disease". Oncology Letters 13, no. 3 (2017): 1775-1782. https://doi.org/10.3892/ol.2017.5623
Copy and paste a formatted citation
x
Spandidos Publications style
Duan YF, Sun DL, Chen J, Zhu F and An Y: MicroRNA‑29a/b/c targets iNOS and is involved in protective remote ischemic preconditioning in an ischemia‑reperfusion rat model of non‑alcoholic fatty liver disease. Oncol Lett 13: 1775-1782, 2017.
APA
Duan, Y., Sun, D., Chen, J., Zhu, F., & An, Y. (2017). MicroRNA‑29a/b/c targets iNOS and is involved in protective remote ischemic preconditioning in an ischemia‑reperfusion rat model of non‑alcoholic fatty liver disease. Oncology Letters, 13, 1775-1782. https://doi.org/10.3892/ol.2017.5623
MLA
Duan, Y., Sun, D., Chen, J., Zhu, F., An, Y."MicroRNA‑29a/b/c targets iNOS and is involved in protective remote ischemic preconditioning in an ischemia‑reperfusion rat model of non‑alcoholic fatty liver disease". Oncology Letters 13.3 (2017): 1775-1782.
Chicago
Duan, Y., Sun, D., Chen, J., Zhu, F., An, Y."MicroRNA‑29a/b/c targets iNOS and is involved in protective remote ischemic preconditioning in an ischemia‑reperfusion rat model of non‑alcoholic fatty liver disease". Oncology Letters 13, no. 3 (2017): 1775-1782. https://doi.org/10.3892/ol.2017.5623
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