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Article

Usefulness of miRNA profiles for predicting pathological responses to neoadjuvant chemotherapy in patients with human epidermal growth factor receptor 2‑positive breast cancer

  • Authors:
    • Hideyuki Ohzawa
    • Atsushi Miki
    • Takumi Teratani
    • Satomi Shiba
    • Yasunaru Sakuma
    • Wataru Nishimura
    • Yasuko Noda
    • Noriyoshi Fukushima
    • Hirofumi Fujii
    • Yasuo Hozumi
    • Hirofumi Mukai
    • Yoshikazu Yasuda
  • View Affiliations / Copyright

    Affiliations: Department of Breast Oncology, Jichi Medical University, Shimotsuke, Tochigi 329‑0498, Japan, Department of Gastrointestinal Surgery, Jichi Medical University, Shimotsuke, Tochigi 329‑0498, Japan, Division of Development of Animal Resource, Center for Development of Advanced Medical Technology, Jichi Medical University, Shimotsuke, Tochigi 329‑0498, Japan, Division of Bio‑imaging and Neuro‑cell Science, Department of Anatomy, Jichi Medical University, Shimotsuke, Tochigi 329‑0498, Japan, Department of Diagnostic Pathology, Jichi Medical University, Shimotsuke, Tochigi 329‑0498, Japan, Department of Clinical Oncology, Jichi Medical University, Shimotsuke, Tochigi 329‑0498, Japan, Division of Breast and Medical Oncology, National Cancer Center Hospital East, Kashiwa, Chiba 277‑8577, Japan
  • Pages: 1731-1740
    |
    Published online on: January 19, 2017
       https://doi.org/10.3892/ol.2017.5628
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Abstract

Pathological complete response (pCR) is considered to be a useful prognostic marker for neoadjuvant chemotherapy to improve the survival rate of patients with operable breast cancer. In the present study, we identified differentially expressed microRNAs (miRNAs) between pCR and non‑pCR groups of patients with human epidermal growth factor receptor 2 (HER2)‑positive breast cancer who received neoadjuvant chemotherapy with trastuzumab. Expression profiles were examined by miRNA microarrays using total RNA extracted from formalin‑fixed, paraffin‑embedded tissues from pretreatment biopsy specimens. Significant differences were observed in miRNAs associated with pCR between the luminal B‑like (HER2‑positive) and HER2‑positive (non­luminal) subtypes, which were further classified according to their estrogen receptor (ER) status. Prediction models constructed with differentially expressed miRNAs performed well. In conclusion, the combination of miRNA profiles and ER status may improve the accuracy of pCR prediction in patients with HER2‑positive breast cancer and enable the development of personalized treatment regimens.
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Copy and paste a formatted citation
Spandidos Publications style
Ohzawa H, Miki A, Teratani T, Shiba S, Sakuma Y, Nishimura W, Noda Y, Fukushima N, Fujii H, Hozumi Y, Hozumi Y, et al: Usefulness of miRNA profiles for predicting pathological responses to neoadjuvant chemotherapy in patients with human epidermal growth factor receptor 2‑positive breast cancer. Oncol Lett 13: 1731-1740, 2017.
APA
Ohzawa, H., Miki, A., Teratani, T., Shiba, S., Sakuma, Y., Nishimura, W. ... Yasuda, Y. (2017). Usefulness of miRNA profiles for predicting pathological responses to neoadjuvant chemotherapy in patients with human epidermal growth factor receptor 2‑positive breast cancer. Oncology Letters, 13, 1731-1740. https://doi.org/10.3892/ol.2017.5628
MLA
Ohzawa, H., Miki, A., Teratani, T., Shiba, S., Sakuma, Y., Nishimura, W., Noda, Y., Fukushima, N., Fujii, H., Hozumi, Y., Mukai, H., Yasuda, Y."Usefulness of miRNA profiles for predicting pathological responses to neoadjuvant chemotherapy in patients with human epidermal growth factor receptor 2‑positive breast cancer". Oncology Letters 13.3 (2017): 1731-1740.
Chicago
Ohzawa, H., Miki, A., Teratani, T., Shiba, S., Sakuma, Y., Nishimura, W., Noda, Y., Fukushima, N., Fujii, H., Hozumi, Y., Mukai, H., Yasuda, Y."Usefulness of miRNA profiles for predicting pathological responses to neoadjuvant chemotherapy in patients with human epidermal growth factor receptor 2‑positive breast cancer". Oncology Letters 13, no. 3 (2017): 1731-1740. https://doi.org/10.3892/ol.2017.5628
Copy and paste a formatted citation
x
Spandidos Publications style
Ohzawa H, Miki A, Teratani T, Shiba S, Sakuma Y, Nishimura W, Noda Y, Fukushima N, Fujii H, Hozumi Y, Hozumi Y, et al: Usefulness of miRNA profiles for predicting pathological responses to neoadjuvant chemotherapy in patients with human epidermal growth factor receptor 2‑positive breast cancer. Oncol Lett 13: 1731-1740, 2017.
APA
Ohzawa, H., Miki, A., Teratani, T., Shiba, S., Sakuma, Y., Nishimura, W. ... Yasuda, Y. (2017). Usefulness of miRNA profiles for predicting pathological responses to neoadjuvant chemotherapy in patients with human epidermal growth factor receptor 2‑positive breast cancer. Oncology Letters, 13, 1731-1740. https://doi.org/10.3892/ol.2017.5628
MLA
Ohzawa, H., Miki, A., Teratani, T., Shiba, S., Sakuma, Y., Nishimura, W., Noda, Y., Fukushima, N., Fujii, H., Hozumi, Y., Mukai, H., Yasuda, Y."Usefulness of miRNA profiles for predicting pathological responses to neoadjuvant chemotherapy in patients with human epidermal growth factor receptor 2‑positive breast cancer". Oncology Letters 13.3 (2017): 1731-1740.
Chicago
Ohzawa, H., Miki, A., Teratani, T., Shiba, S., Sakuma, Y., Nishimura, W., Noda, Y., Fukushima, N., Fujii, H., Hozumi, Y., Mukai, H., Yasuda, Y."Usefulness of miRNA profiles for predicting pathological responses to neoadjuvant chemotherapy in patients with human epidermal growth factor receptor 2‑positive breast cancer". Oncology Letters 13, no. 3 (2017): 1731-1740. https://doi.org/10.3892/ol.2017.5628
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